TSHB

TSHB
Identifiers
Aliases	TSHB , TSH-B, TSH-BETA, thyroid stimulating hormone beta, Thyroid stimulating hormone, beta, thyroid stimulating hormone subunit beta
External IDs	OMIM: 188540; MGI: 98848; HomoloGene: 463; GeneCards: TSHB; OMA:TSHB - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p13.2 Start 115,029,826 bp [1] End 115,034,302 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3 F2.2|3 45.25 cM Start 102,682,781 bp [2] End 102,690,034 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in anterior pituitary testicle buccal mucosa cell tibialis anterior muscle tibial arteries gastric mucosa islet of Langerhans Descending thoracic aorta body of uterus Achilles tendon Top expressed in pituitary gland median eminence anterior pituitary arcuate nucleus left lung lobe embryo pars tuberalis granulocyte pars distalis of adenohypophysis ascending aorta More reference expression data BioGPS n/a
Gene ontology Molecular function hormone activity Cellular component extracellular region extracellular space cytoplasm Biological process response to calcium ion cell-cell signaling anatomical structure morphogenesis G protein-coupled receptor signaling pathway response to vitamin A peptide hormone processing response to estrogen hormone-mediated signaling pathway regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7252 22094 Ensembl ENSG00000134200 ENSMUSG00000027857 UniProt P01222 P12656 RefSeq (mRNA) NM_000549 NM_001277991 NM_001165939 NM_001165940 NM_009432 RefSeq (protein) NP_000540 NP_001264920 NP_001159411 NP_001159412 NP_033458 Location (UCSC) Chr 1: 115.03 – 115.03 Mb Chr 3: 102.68 – 102.69 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Thyroid stimulating hormone, beta also known as TSHB is a protein which in humans is encoded by the TSHB gene. ^{[5] [6]}

Function

Thyrotropin-stimulating hormone (TSH) is a noncovalently linked glycoprotein heterodimer and is part of a family of pituitary hormones containing a common alpha subunit (TSHA) and a unique beta subunit (this protein) that confers specificity. ^[7]

See also

• thyroid stimulating hormone

References

1. GRCh38: Ensembl release 89: ENSG00000134200 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027857 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wondisford FE, Radovick S, Moates JM, Usala SJ, Weintraub BD (September 1988). "Isolation and characterization of the human thyrotropin beta-subunit gene. Differences in gene structure and promoter function from murine species". J. Biol. Chem. 263 (25): 12538–42. doi: 10.1016/S0021-9258(18)37788-3 . PMID   2457586.
6. Tatsumi K, Hayashizaki Y, Hiraoka Y, Miyai K, Matsubara K (December 1988). "The structure of the human thyrotropin beta-subunit gene". Gene. 73 (2): 489–97. doi:10.1016/0378-1119(88)90513-6. PMID   3243440.
7. "Entrez Gene: TSHB".

Further reading

• Bonomi M, Proverbio MC, Weber G, et al. (2001). "Hyperplastic pituitary gland, high serum glycoprotein hormone alpha-subunit, and variable circulating thyrotropin (TSH) levels as hallmark of central hypothyroidism due to mutations of the TSH beta gene". J. Clin. Endocrinol. Metab. 86 (4): 1600–4. doi: 10.1210/jcem.86.4.7411 . PMID   11297590.
• Vuissoz JM, Deladoëy J, Buyukgebiz A, et al. (2001). "New autosomal recessive mutation of the TSH-beta subunit gene causing central isolated hypothyroidism". J. Clin. Endocrinol. Metab. 86 (9): 4468–71. doi: 10.1210/jcem.86.9.7876 . PMID   11549695.
• Karges B, LeHeup B, Schoenle E, et al. (2004). "Compound heterozygous and homozygous mutations of the TSHbeta gene as a cause of congenital central hypothyroidism in Europe". Horm. Res. 62 (3): 149–55. doi:10.1159/000080071. PMID   15297803. S2CID   28309388.
• Kabadi UM, Premachandra BN (2007). "Serum thyrotropin in Graves' disease: a more reliable index of circulating thyroid-stimulating immunoglobulin level than thyroid function?". Endocr Pract. 13 (6): 615–9. doi:10.4158/ep.13.6.615. PMID   17954417.
• Miyai S, Yoshimura S, Iwasaki Y, et al. (2005). "Induction of GH, PRL, and TSH beta mRNA by transfection of Pit-1 in a human pituitary adenoma-derived cell line". Cell Tissue Res. 322 (2): 269–77. doi:10.1007/s00441-005-0033-z. PMID   16133148. S2CID   37186810.
• Pierce JG (1971). "Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones". Endocrinology. 89 (6): 1331–44. doi:10.1210/endo-89-6-1331. PMID   5002675.
• Atzmon G, Barzilai N, Surks MI, Gabriely I (2009). "Genetic Predisposition to Elevated Serum Thyrotropin Is Associated with Exceptional Longevity". J. Clin. Endocrinol. Metab. 94 (12): 4768–75. doi:10.1210/jc.2009-0808. PMC   2795660 . PMID   19837933.
• Landa I, Ruiz-Llorente S, Montero-Conde C, et al. (2009). Gibson G (ed.). "The Variant rs1867277 in FOXE1 Gene Confers Thyroid Cancer Susceptibility through the Recruitment of USF1/USF2 Transcription Factors". PLOS Genet. 5 (9) e1000637. doi: 10.1371/journal.pgen.1000637 . PMC   2727793 . PMID   19730683.
• Pohlenz J, Dumitrescu A, Aumann U, et al. (2002). "Congenital secondary hypothyroidism caused by exon skipping due to a homozygous donor splice site mutation in the TSHbeta-subunit gene". J. Clin. Endocrinol. Metab. 87 (1): 336–9. doi: 10.1210/jcem.87.1.8154 . PMID   11788671.
• Miyoshi I, Kasai N, Hayashizaki Y (1994). "[Structure and regulation of human thyroid-stimulating hormone (TSH) gene]". Nippon Rinsho. 52 (4): 940–7. PMID   8196184.
• Borck G, Topaloglu AK, Korsch E, et al. (2004). "Four new cases of congenital secondary hypothyroidism due to a splice site mutation in the thyrotropin-beta gene: phenotypic variability and founder effect". J. Clin. Endocrinol. Metab. 89 (8): 4136–41. doi: 10.1210/jc.2004-0494 . PMID   15292359.
• Comings DE, Gade-Andavolu R, Gonzalez N, et al. (2000). "A multivariate analysis of 59 candidate genes in personality traits: the temperament and character inventory". Clin. Genet. 58 (5): 375–85. doi:10.1034/j.1399-0004.2000.580508.x. PMID   11140838. S2CID   14733771.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Clark AG, Glanowski S, Nielsen R, et al. (2003). "Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios". Science. 302 (5652): 1960–3. Bibcode:2003Sci...302.1960C. doi:10.1126/science.1088821. PMID   14671302. S2CID   6682593.
• Loinder K, Söderström M (2005). "An LXXLL motif in nuclear receptor corepressor mediates ligand-induced repression of the thyroid stimulating hormone-beta gene". J. Steroid Biochem. Mol. Biol. 97 (4): 322–7. doi:10.1016/j.jsbmb.2005.06.031. PMID   16216492. S2CID   45326566.
• Luttrell LM (2008). "Reviews in molecular biology and biotechnology: transmembrane signaling by G protein-coupled receptors". Mol. Biotechnol. 39 (3): 239–64. doi:10.1007/s12033-008-9031-1. PMID   18240029. S2CID   45173229.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Brumm H, Pfeufer A, Biebermann H, et al. (2002). "Congenital central hypothyroidism due to homozygous thyrotropin beta 313 Delta T mutation is caused by a Founder effect". J. Clin. Endocrinol. Metab. 87 (10): 4811–6. doi: 10.1210/jc.2002-020297 . PMID   12364478.
• Benhadi N, Wiersinga WM, Reitsma JB, et al. (2009). "Higher maternal TSH levels in pregnancy are associated with increased risk for miscarriage, fetal or neonatal death". Eur. J. Endocrinol. 160 (6): 985–91. doi: 10.1530/EJE-08-0953 . PMID   19273570.
• Schaefer JS, Klein JR (2009). "A novel thyroid stimulating hormone β-subunit isoform in human pituitary, peripheral blood leukocytes, and thyroid". Gen. Comp. Endocrinol. 162 (3): 241–4. doi:10.1016/j.ygcen.2009.04.006. PMC   2689139 . PMID   19364510.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.