Trigeminal neuralgia

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Trigeminal neuralgia
Other namesTic douloureux, [1] prosopalgia, [2] Fothergill's disease, [3]
Gray778.png
The trigeminal nerve and its three major divisions (shown in yellow): the ophthalmic nerve (V1), the maxillary nerve (V2), and the mandibular nerve (V3)
Specialty Neurology
Symptoms Typical: episodes of severe, sudden, shock-like pain in one side of the face that lasts for seconds to minutes [1]
Atypical: constant burning pain [1]
Complications Depression [4]
Usual onset> 50 years old [1]
TypesTypical and atypical trigeminal neuralgia [1]
Causes Believed to be due to problems with myelin of trigeminal nerve [1] [5]
Diagnostic method Based on symptoms [1]
Differential diagnosis Postherpetic neuralgia [1]
TreatmentMedication, surgery [1]
Medication Carbamazepine, oxcarbazepine [5]
Prognosis 80% improve with initial treatment [5]
Frequency1 in 8,000 people per year [1]

Trigeminal neuralgia (TN or TGN), also called Fothergill disease, tic douloureux, or trifacial neuralgia, is a long-term pain disorder that affects the trigeminal nerve, [6] [1] the nerve responsible for sensation in the face and motor functions such as biting and chewing. It is a form of neuropathic pain. [7] There are two main types: typical and atypical trigeminal neuralgia. [1]

Contents

The typical form results in episodes of severe, sudden, shock-like pain in one side of the face that lasts for seconds to a few minutes. Groups of these episodes can occur over a few hours. The atypical form results in a constant burning pain that is less severe. Episodes may be triggered by any touch to the face. [1] Both forms may occur in the same person. Pain from the disease has been linked to mental-health issues, especially depression. [4]

The exact cause is unknown, but believed to involve loss of the myelin of the trigeminal nerve. [5] This might occur due to nerve compression from a blood vessel as the nerve exits the brain stem, multiple sclerosis, stroke, or trauma. Less common causes include a tumor or arteriovenous malformation. It is a type of nerve pain. Diagnosis is typically based on the symptoms, after ruling out other possible causes such as postherpetic neuralgia. [7] [1]

Treatment includes medication or surgery. The anticonvulsant carbamazepine or oxcarbazepine is usually the initial treatment, and is effective in about 90% of people. [7] Side effects are frequently experienced that necessitate drug withdrawal in as many as 23% of patients. [7] Other options include lamotrigine, baclofen, gabapentin, amitriptyline, and pimozide. [5] Opioids are not usually effective in the typical form. In those who do not improve or become resistant to other measures, a number of types of surgery may be tried. [5] [1]

Trigeminal neuralgia affects an estimated 0.03% to 0.30% of people around the world, with a 3:1 ratio between women and men. [8] It usually begins in people over 50 years old, but can occur at any age. [1] The condition was first described in detail in 1773 by John Fothergill. [9]

Signs and symptoms

Trigeminal neuralgia Trigeminal Neuralgia.png
Trigeminal neuralgia

This disorder is characterized by episodes of severe facial pain along the trigeminal nerve divisions. The trigeminal nerve is a paired cranial nerve that has three major branches - the ophthalmic nerve (V1), the maxillary nerve (V2), and the mandibular nerve (V3). Any or all branches of the nerve may be affected. Trigeminal neuralgia most commonly involves the middle branch (the maxillary nerve or V2) and lower branch (mandibular nerve or V3) of the trigeminal nerve. [10]

An individual attack usually lasts from a few seconds to several minutes or hours, but these can repeat for hours with very short intervals between attacks. In other instances, only four to 10 attacks are experienced daily. The episodes of intense pain may occur paroxysmally. To describe the pain sensation, people often describe a trigger area on the face so sensitive that touching or even air currents can trigger an episode, but in many people, the pain is generated spontaneously without any apparent stimulation.

It affects lifestyle, as it can be triggered by common activities such as eating, talking, shaving, and brushing teeth. The wind, chewing, and talking can aggravate the condition in many patients. The attacks are said, by those affected, to feel like stabbing electric shocks, burning, sharp, pressing, crushing, exploding, or shooting pain that becomes intractable. [7]

The pain also tends to occur in cycles with remissions lasting months or even years. Pain attacks are known to worsen in frequency or severity over time in some people. Pain may migrate to other branches over time, but in some people remains very stable. [11]

Bilateral (occurring on both sides) trigeminal neuralgia is very rare except for trigeminal neuralgia caused by multiple sclerosis (MS). This normally indicates problems with both trigeminal nerves, since one nerve serves the left side of the face and the other serves the right side. Occasional reports of bilateral trigeminal neuralgia reflect successive episodes of unilateral (only one side) pain switching the side of the face rather than pain occurring simultaneously on both sides. [12]

Rapid spreading of the pain, bilateral involvement, or simultaneous participation with other major nerve trunks (such as painful tic convulsive of nerves V and VII or occurrence of symptoms in the V and IX nerves) may suggest a systemic cause. Systemic causes could include MS or expanding cranial tumors. [13]

The severity of the pain makes washing the face, shaving, and performing good oral hygiene more difficult. The pain has a significant impact on activities of daily living, especially as those affected live in fear of when they are going to get their next attack of pain and how severe it will be. It can lead to severe depression and anxiety. [14]

Not all people, though, have the symptoms described above; several variants of TN occur, one of which is atypical trigeminal neuralgia (trigeminal neuralgia, type 2 or trigeminal neuralgia with concomitant pain), [15] based on a recent classification of facial pain. [16] In these instances, a more prolonged, lower-severity background pain can be present for over 50% of the time and is described more as a burning or prickling, rather than a shock.

Trigeminal pain can also occur after an attack of herpes zoster. Postherpetic neuralgia has the same manifestations as in other parts of the body. Herpes zoster oticus typically presents with inability to move many facial muscles, pain in the ear, taste loss on the front of the tongue, dry eyes and mouth, and a vesicular rash. Less than 1% of varicella zoster infections involve the facial nerve and result in this occurring. [17]

Trigeminal deafferentation pain (TDP), also termed anesthesia dolorosa, or colloquially as phantom face pain, is from unintentional damage to a trigeminal nerve following attempts to fix a nerve problem surgically. TDP is usually constant with a burning sensation and numbness and is very difficult to treat, as further surgeries are usually ineffective and possibly detrimental to the person. [18]

Causes

The trigeminal nerve is a mixed cranial nerve responsible for sensory data such as tactition (pressure), thermoception (temperature), and nociception (pain) originating from the face above the jawline; it is also responsible for the motor function of the muscles of mastication (those involved in chewing but not facial expression). [19]

Several theories exist to explain the possible causes of this pain syndrome. The nerve was once thought to be compressed in the opening from the inside to the outside of the skull; but leading research indicates that it is an enlarged or lengthened blood vessel – most commonly the superior cerebellar artery – compressing or throbbing against the microvasculature of the trigeminal nerve near its connection with the pons. [20] Such a compression can injure the nerve's protective myelin sheath and cause erratic and hyperactive functioning of the nerve. This can lead to pain attacks at the slightest stimulation of any area served by the nerve, as well as hindering the nerve's ability to shut off the pain signals after the stimulation ends. This type of injury may rarely be caused by an aneurysm (an outpouching of a blood vessel), by an arteriovenous malformation, [21] by a tumor; such as an arachnoid cyst or meningioma in the cerebellopontine angle; [22] or by a traumatic event, such as a car accident. [23]

Short-term peripheral compression is often painless. [4] Persistent compression results in local demyelination with no loss of axon potential continuity. Chronic nerve entrapment results in demyelination primarily, with progressive axonal degeneration subsequently. [4] It is, "therefore widely accepted that trigeminal neuralgia is associated with demyelination of axons in the Gasserian ganglion, the dorsal root, or both." [24] This compression may be related to an aberrant branch of the superior cerebellar artery that lies on the trigeminal nerve. [24] Further causes, besides an aneurysm, MS, or cerebellopontine angle tumor, include a posterior fossa tumor, any other expanding lesion, or even brainstem diseases from strokes. [24]

Trigeminal neuralgia is found in 3–4% of people with MS, according to data from seven studies. [25] [26] This is theorized to be due to damage to the spinal trigeminal complex. [27] Trigeminal pain has a similar presentation in patients with and without MS. [28]

Postherpetic neuralgia, which occurs after shingles, may cause similar symptoms if the trigeminal nerve is damaged, called Ramsay Hunt syndrome type 2.

When no structural cause is apparent, the syndrome is called idiopathic TN.

Diagnosis

Trigeminal neuralgia is diagnosed by the result of neurological and physical tests, as well as the individual's medical history. [1] Magnetic resonance angiography can be used to detect vascular compression of the trigeminal nerve and refer patients to surgery. [29]

As with many conditions without clear physical or laboratory diagnoses, TN is often misdiagnosed, and other conditions are also frequently misdiagnosed as TN. [30] [31] A person with TN may see three or four clinicians before a firm diagnosis is made. [30]

Temporomandibular disorder (TMD) can present similarly to TN; differentiating between these conditions can be difficult. [32] Even suspected TN patients who experience brief attacks of sharp pain have had their symptoms resolve after being treated for TMD. [33] TMD pain can also be triggered by movements of the tongue or facial muscles, so TN must be differentiated from masticatory pain by differentiating between the clinical characteristics of deep somatic pain and neuropathic pain. Masticatory pain will not be arrested by a conventional mandibular local anesthetic block. [13] One quick test a dentist might perform is a conventional inferior dental local anesthetic block. If the pain is in the treated branch, the block will not arrest masticatory pain but will alleviate TN pain. [34]

Management

Some evidence points towards the need to quickly treat and diagnose TN. The longer a patient has TN, reversing the neural pathways associated with the pain are thought to be more difficult.[ citation needed ]

Medical

Surgical

Microvascular decompression provides freedom from pain in about 75% of patients presenting with drug-resistant TN. [40] [41] [42] While there may be pain relief after surgery, there is also a risk of adverse effects, such as facial numbness. Percutaneous radiofrequency thermorhizotomy may also be effective [43] as may stereotactic radiosurgery; however the effectiveness decreases with time. [44]

Surgical procedures can be separated into nondestructive and destructive:

Nondestructive

  • Microvascular decompression involves a small incision behind the ear and some bone removal from the area. An incision through the meninges is made to expose the nerve. Any vascular compressions of the nerve are carefully moved and a sponge-like pad is placed between the compression and nerve, stopping unwanted pulsation and allowing myelin sheath healing.[ citation needed ]

Destructive

All destructive procedures cause facial numbness after relief, as well as pain relief. [41]

  • Percutaneous techniques, which all involve a needle or catheter entering the face up to the origin where the nerve splits into three divisions and then damaging this area, purposely, produce numbness, but also stop pain signals. These techniques are proven effective, [43] especially in those where other interventions have failed or in those who are medically unfit for surgery, such as the elderly.
  • Balloon compression uses inflation of a balloon at this point, causing damage and stopping pain signals.
  • Glycerol injection, deposition of corrosive liquid glycerol at this point, causes damage to the nerve to hinder pain signals.
  • Radiofrequency thermocoagulation rhizotomy is the application of a heated needle to damage the nerve at this point.
  • Stereotactic radiosurgery is a form of radiation therapy that focuses high-power energy on a small area of the body. [45]

Support

Psychological and social support have been found to play a key role in the management of chronic illnesses and chronic pain conditions, such as TN. Chronic pain can cause constant frustration to individuals and those around them. [46]

History

Edvard Munch's The Scream has been used as a symbol of facial pain, generally, and also specifically of TN. The Scream.jpg
Edvard Munch's The Scream has been used as a symbol of facial pain, generally, and also specifically of TN.

Trigeminal neuralgia was first described by physician John Fothergill and treated surgically by John Murray Carnochan, both of whom were graduates of the University of Edinburgh Medical School. Historically, TN has been called "suicide disease" due to studies by the pioneering forefather in neurosurgery Harvey Cushing involving 123 cases of TN between 1896 and 1912. In those studies, it produced intense pain, higher rates of suicidal ideation in patients with severe migraines, and links to higher rates of depression, anxiety, and sleep disorders. [49] [50] [51]

Society and culture

Some individuals of note with TN include:

See also

References

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