KLF5

Last updated
KLF5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases KLF5 , BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5
External IDs OMIM: 602903 MGI: 1338056 HomoloGene: 37520 GeneCards: KLF5
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001730
NM_001286818

NM_009769

RefSeq (protein)

NP_001273747
NP_001721

NP_033899

Location (UCSC) Chr 13: 73.05 – 73.08 Mb Chr 14: 99.54 – 99.55 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene. [5] [6]

Contents

Function

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor. [6]

Interactions

KLF5 has been shown to interact with Protein SET. [7]

Clinical significance

KLF5 expression has been linked to higher survival rates for lung cancer patients. [8]

See also

Related Research Articles

In molecular genetics, the Krüppel-like family of transcription factors (KLFs) are a set of eukaryotic C2H2 zinc finger DNA-binding proteins that regulate gene expression. This family has been expanded to also include the Sp transcription factor and related proteins, forming the Sp/KLF family.

<span class="mw-page-title-main">KLF6</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 6 is a protein that in humans is encoded by the KLF6 gene.

<span class="mw-page-title-main">XBP1</span> Protein-coding gene in the species Homo sapiens

X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 gene is located on chromosome 22 while a closely related pseudogene has been identified and localized to chromosome 5. The XBP1 protein is a transcription factor that regulates the expression of genes important to the proper functioning of the immune system and in the cellular stress response.

<span class="mw-page-title-main">KLF4</span> Protein-coding gene in the species Homo sapiens

Kruppel-like factor 4 is a member of the KLF family of zinc finger transcription factors, which belongs to the relatively large family of SP1-like transcription factors. KLF4 is involved in the regulation of proliferation, differentiation, apoptosis and somatic cell reprogramming. Evidence also suggests that KLF4 is a tumor suppressor in certain cancers, including colorectal cancer. It has three C2H2-zinc fingers at its carboxyl terminus that are closely related to another KLF, KLF2. It has two nuclear localization sequences that signals it to localize to the nucleus. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSCs).

<span class="mw-page-title-main">GABPA</span> Protein-coding gene in the species Homo sapiens

GA-binding protein alpha chain is a protein that in humans is encoded by the GABPA gene.

<span class="mw-page-title-main">YY1</span> Transcriptional repressor protein

YY1 is a transcriptional repressor protein in humans that is encoded by the YY1 gene.

<span class="mw-page-title-main">Myocyte-specific enhancer factor 2A</span> Protein-coding gene in the species Homo sapiens

Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction.

<span class="mw-page-title-main">CTBP2</span> Protein-coding gene in the species Homo sapiens

C-terminal-binding protein 2 also known as CtBP2 is a protein that in humans is encoded by the CTBP2 gene.

<span class="mw-page-title-main">HOXC4</span> Protein-coding gene in the species Homo sapiens

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

<span class="mw-page-title-main">SOX5</span> Protein-coding gene in Homo sapiens

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.

<span class="mw-page-title-main">SOX6</span> Protein-coding gene in the species Homo sapiens

Transcription factor SOX-6 is a protein that in humans is encoded by the SOX6 gene.

<span class="mw-page-title-main">SOX8</span> Protein-coding gene in the species Homo sapiens

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

<span class="mw-page-title-main">ZNF10</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 10 is a protein that in humans is encoded by the ZNF10 gene.

<span class="mw-page-title-main">KLF8</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene. KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.

<span class="mw-page-title-main">ZFP161</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 161 homolog is a protein that in humans is encoded by the ZBTB14 gene.

<span class="mw-page-title-main">ENO3</span> Protein-coding gene in the species Homo sapiens

Enolase 3 (ENO3), more commonly known as beta-enolase (ENO-β), is an enzyme that in humans is encoded by the ENO3 gene.

<span class="mw-page-title-main">KLF3</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 3 is a protein that in humans is encoded by the KLF3 gene.

<span class="mw-page-title-main">ZNF239</span> Protein-coding gene in the species Homo sapiens

Zinc finger protein 239 is a protein that in humans is encoded by the ZNF239 gene.

<span class="mw-page-title-main">KLF17</span> Protein-coding gene in the species Homo sapiens

Krueppel-like factor 17 is a protein that in humans is encoded by the KLF17 gene.

<span class="mw-page-title-main">KLF15</span> Protein-coding gene in the species Homo sapiens

Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factor family. Its former designation KKLF stands for kidney-enriched Krüppel-like factor.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000102554 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000005148 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Sogawa K, Imataka H, Yamasaki Y, Kusume H, Abe H, Fujii-Kuriyama Y (Apr 1993). "cDNA cloning and transcriptional properties of a novel GC box-binding protein, BTEB2". Nucleic Acids Research. 21 (7): 1527–32. doi:10.1093/nar/21.7.1527. PMC   309358 . PMID   8479902.
  6. 1 2 "Entrez Gene: KLF5 Kruppel-like factor 5 (intestinal)".
  7. Miyamoto S, Suzuki T, Muto S, Aizawa K, Kimura A, Mizuno Y, Nagino T, Imai Y, Adachi N, Horikoshi M, Nagai R (Dec 2003). "Positive and negative regulation of the cardiovascular transcription factor KLF5 by p300 and the oncogenic regulator SET through interaction and acetylation on the DNA-binding domain". Molecular and Cellular Biology. 23 (23): 8528–41. doi:10.1128/MCB.23.23.8528-8541.2003. PMC   262669 . PMID   14612398.
  8. "Research update from the MCM team (May 2024)". World Community Grid. 13 May 2024. Retrieved 21 May 2024.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.