TLX2

TLX2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3A03
Identifiers
Aliases	TLX2 , HOX11L1, NCX, T-cell leukemia homeobox 2, T cell leukemia homeobox 2
External IDs	OMIM: 604240 MGI: 1350935 HomoloGene: 7575 GeneCards: TLX2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	74,517,148 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	83,047,274 bp
RNA expression pattern
	Top expressed in
	transverse colon; ; rectum; ; duodenum; ; appendix; ; gastric mucosa; ; frontal lobe; ; prefrontal cortex; ; Brodmann area 9; ; body of stomach; ; fundus;
	Top expressed in
	adrenal medulla; ; autonomic nervous system; ; parasympathetic nervous system; ; female urethra; ; male urethra; ; autonomic ganglion; ; sympathetic nervous system; ; enteric nervous system; ; stellate ganglion; ; Greater petrosal nerve;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding ; DNA-binding transcription activator activity, RNA polymerase II-specific ; sequence-specific DNA binding ; DNA-binding transcription factor activity, RNA polymerase II-specific ; DNA-binding transcription factor activity ;
Cellular component	cytoplasm ; nucleus ; cellular component ;
Biological process	multicellular organism development ; enteric nervous system development ; mesoderm formation ; regulation of transcription, DNA-templated ; negative regulation of dendrite morphogenesis ; transcription, DNA-templated ; transcription by RNA polymerase II ; positive regulation of transcription by RNA polymerase II ;
	Sources:Amigo / QuickGO
Orthologs
	3196
	21909
	ENSG00000115297
	ENSMUSG00000068327
	O43763
	Q61663
	NM_016170 ; NM_001534
	NM_009392
	NP_057254
	NP_033418
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated April 24, 2024

T-cell leukemia homeobox protein 2 is a protein that in humans is encoded by the TLX2 gene.^[5]^[6]

Interactions

TLX2 has been shown to interact with YWHAH.^[7]

Related Research Articles

Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.

Homeodomain-interacting protein kinase 2 is an enzyme that in humans is encoded by the HIPK2 gene. HIPK2 can be categorized as a Serine/Threonine Protein kinase, specifically one that interacts with homeodomain transcription factors. It belongs to a family of protein kinases known as the DYRK kinases. Within this family HIPK2 belongs to a group of homeodomain-interacting protein kinases (HIPKs), including HIPK1 and HIPK3. HIPK2 can be found in a wide variety of species and its functions in gene expression and apoptosis are regulated by several different mechanisms.

Pre-B-cell leukemia transcription factor 1 is a protein that in humans is encoded by the PBX1 gene. The homologous protein in Drosophila is known as extradenticle, and causes changes in embryonic development.

NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.

Homeobox protein Nkx-2.5 is a protein that in humans is encoded by the NKX2-5 gene.

Homeobox protein Hox-A1 is a protein that in humans is encoded by the HOXA1 gene.

Homeobox protein Meis1 is a protein that in humans is encoded by the MEIS1 gene.

Homeobox protein Hox-A5 is a protein that in humans is encoded by the HOXA5 gene.

Hematopoietically-expressed homeobox protein HHEX is a protein that in humans is encoded by the HHEX gene and also known as Proline Rich Homeodomain protein PRH.

Homeobox protein Hox-B2 is a protein that in humans is encoded by the HOXB2 gene.

Homeobox protein Hox-B9 is a protein that in humans is encoded by the HOXB9 gene.

Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene.

Paired mesoderm homeobox protein 2A is a protein that in humans is encoded by the PHOX2A gene.

Homeobox protein Hox-C4 is a protein that in humans is encoded by the HOXC4 gene.

Pre-B-cell leukemia transcription factor 2 is a protein that in humans is encoded by the PBX2 gene.

Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.

Homeobox protein Hox-D4 is a protein that in humans is encoded by the HOXD4 gene.

Homeobox protein Hox-C13 is a protein that in humans is encoded by the HOXC13 gene.

Homeobox protein engrailed-1 is a protein that in humans is encoded by the EN1 gene.

Homeodomain-interacting protein kinase 1 is an enzyme that, in humans is encoded by the HIPK1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115297 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068327 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1". Cytogenetics and Cell Genetics. 84 (1–2): 115–7. doi:10.1159/000015234. PMID 10343123. S2CID 21498122.
↑ "Entrez Gene: TLX2 T-cell leukemia homeobox 2".
↑ Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". The Journal of Biological Chemistry. 273 (39): 25356–63. doi: 10.1074/jbc.273.39.25356 . PMID 9738002.

Kaifi JT, Wagner M, Schurr PG, Wachowiak R, Reichelt U, Yekebas EF, Mann O, Vashist Y, Kleinhans H, Link BC, Strate T, Kalinin V, Izbicki JR (October 2006). "Allelic loss of Hox11L1 gene locus predicts outcome of gastrointestinal stromal tumors". Oncology Reports. 16 (4): 915–9. doi: 10.3892/or.16.4.915 . PMID 16969514.
Borghini S, Bachetti T, Fava M, Di Duca M, Cargnin F, Fornasari D, Ravazzolo R, Ceccherini I (April 2006). "The TLX2 homeobox gene is a transcriptional target of PHOX2B in neural-crest-derived cells". The Biochemical Journal. 395 (2): 355–61. doi:10.1042/BJ20051386. PMC 1422762 . PMID 16402914.
Parisi MA, Lipman NS, Clarke CM, Taylor B, Kapur RP (November 2005). "Evaluation of Hox11L1 in the fmc/fmc rat model of chronic intestinal pseudo-obstruction". Journal of Pediatric Surgery. 40 (11): 1760–5. doi:10.1016/j.jpedsurg.2005.07.010. PMID 16291166.
Iitsuka Y, Shimizu H, Kang MM, Sasagawa K, Sekiya S, Tokuhisa T, Hatano M (August 1999). "An enhancer element for expression of the Ncx (Enx, Hox11L1) gene in neural crest-derived cells". The Journal of Biological Chemistry. 274 (34): 24401–7. doi: 10.1074/jbc.274.34.24401 . PMID 10446220.
Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". The Journal of Biological Chemistry. 273 (39): 25356–63. doi: 10.1074/jbc.273.39.25356 . PMID 9738002.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115297 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000068327 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10343123-5] Puliti A, Cinti R, Betsos N, Romeo G, Ceccherini I (Jun 1999). "HOX11L1, a gene involved in peripheral nervous system development, maps to human chromosome 2p13.1→p12 and mouse chromosome 6C3-D1". Cytogenetics and Cell Genetics. 84 (1–2): 115–7. doi:10.1159/000015234. PMID 10343123. S2CID 21498122.

[entrez-6] "Entrez Gene: TLX2 T-cell leukemia homeobox 2".

[pmid9738002-7] Tang SJ, Suen TC, McInnes RR, Buchwald M (September 1998). "Association of the TLX-2 homeodomain and 14-3-3eta signaling proteins". The Journal of Biological Chemistry. 273 (39): 25356–63. doi: 10.1074/jbc.273.39.25356 . PMID 9738002.

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TLX2

Contents

Interactions

Related Research Articles

References

Further reading