SIX4

SIX4
Identifiers
Aliases	SIX4 , AREC3, SIX homeobox 4
External IDs	OMIM: 606342 MGI: 106034 HomoloGene: 69089 GeneCards: SIX4
Gene location (Human) Chr. Chromosome 14 (human) [1] Band 14q23.1 Start 60,709,539 bp [1] End 60,724,351 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 C3 Start 73,099,609 bp [2] End 73,113,456 bp [2]
Gene ontology Molecular function • sequence-specific DNA binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • DNA binding • GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • transcription regulatory region sequence-specific DNA binding Cellular component • cytoplasm • cell nucleus • transcription factor complex Biological process • tongue development • trigeminal ganglion development • sarcomere organization • generation of neurons • regulation of branch elongation involved in ureteric bud branching • negative regulation of apoptotic process • positive regulation of branching involved in ureteric bud morphogenesis • transcription, DNA-templated • multicellular organism development • negative regulation of satellite cell differentiation • pharyngeal system development • anatomical structure morphogenesis • embryonic skeletal system morphogenesis • inner ear morphogenesis • myotome development • fungiform papilla morphogenesis • skeletal muscle fiber differentiation • positive regulation of ureteric bud formation • regulation of gene expression • embryonic cranial skeleton morphogenesis • anatomical structure development • regulation of synaptic growth at neuromuscular junction • olfactory placode formation • myoblast migration • thymus development • positive regulation of transcription, DNA-templated • regulation of epithelial cell proliferation • metanephric mesenchyme development • male sex determination • skeletal muscle tissue development • negative regulation of neuron apoptotic process • regulation of protein localization • male sex differentiation • regulation of transcription, DNA-templated • positive regulation of transcription from RNA polymerase II promoter • transcription from RNA polymerase II promoter • male gonad development • negative regulation of transcription, DNA-templated • protein localization to nucleus Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	51804	20474
Ensembl	ENSG00000100625	ENSMUSG00000034460
UniProt	Q9UIU6	Q61321
RefSeq (mRNA)	NM_017420	NM_011382 NM_001362272
RefSeq (protein)	NP_059116	NP_035512 NP_001349201
Location (UCSC)	Chr 14: 60.71 – 60.72 Mb	Chr 12: 73.1 – 73.11 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein SIX4 is a protein that in humans is encoded by the SIX4 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000100625 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034460 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gallardo ME, Lopez-Rios J, Fernaud-Espinosa I, Granadino B, Sanz R, Ramos C, Ayuso C, Seller MJ, Brunner HG, Bovolenta P, Rodriguez de Cordoba S (Nov 1999). "Genomic cloning and characterization of the human homeobox gene SIX6 reveals a cluster of SIX genes in chromosome 14 and associates SIX6 hemizygosity with bilateral anophthalmia and pituitary anomalies". Genomics. 61 (1): 82–91. doi:10.1006/geno.1999.5916. PMID   10512683.
6. Ozaki H, Yamada K, Kobayashi M, Asakawa S, Minoshima S, Shimizu N, Kajitani M, Kawakami K (May 2000). "Structure and chromosome mapping of the human SIX4 and murine Six4 genes". Cytogenet Cell Genet. 87 (1–2): 108–12. doi:10.1159/000015407. PMID   10640827.
7. "Entrez Gene: SIX4 sine oculis homeobox homolog 4 (Drosophila)".

Further reading

• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC   139241 . PMID   12477932.
• López-Ríos J, Tessmar K, Loosli F, et al. (2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi: 10.1242/dev.00185 . PMID   12441302.
• Ikeda K, Watanabe Y, Ohto H, Kawakami K (2002). "Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein". Mol. Cell. Biol. 22 (19): 6759–66. doi:10.1128/MCB.22.19.6759-6766.2002. PMC   134036 . PMID   12215533.
• Fan X, Brass LF, Poncz M, et al. (2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". J. Biol. Chem. 275 (41): 32129–34. doi: 10.1074/jbc.M004577200 . PMID   10906137.
• Kawakami K, Ohto H, Ikeda K, Roeder RG (1996). "Structure, function and expression of a murine homeobox protein AREC3, a homologue of Drosophila sine oculis gene product, and implication in development". Nucleic Acids Res. 24 (2): 303–10. doi:10.1093/nar/24.2.303. PMC   145635 . PMID   8628654.