EGR4

Last updated
EGR4
Identifiers
Aliases EGR4 , NGFI-C, NGFIC, PAT133, early growth response 4, Early growth response protein 4, AT133
External IDs OMIM: 128992 MGI: 99252 HomoloGene: 1485 GeneCards: EGR4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001965

NM_020596

RefSeq (protein)

NP_001956

NP_065621

Location (UCSC) Chr 2: 73.29 – 73.29 Mb Chr 6: 85.51 – 85.51 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Early growth response protein 4 (EGR-4), also known as AT133, is a protein that in humans is encoded by the EGR4 gene. [5]

EGR-4 is a member of the early growth response (EGF) family of zinc finger transcription factors.

Related Research Articles

EGR1

EGR-1 also known as ZNF268 or NGFI-A is a protein that in humans is encoded by the EGR1 gene.

EGR2

Early growth response protein 2 is a protein that in humans is encoded by the EGR2 gene. EGR2 is a transcription regulatory factor, containing three zinc finger DNA-binding sites, and is highly expressed in a population of migrating neural crest cells. It is later expressed in the neural crest derived cells of the cranial ganglion. The protein encoded by Krox20 contains two cys2his2-type zinc fingers. Krox20 gene expression is restricted to the early hindbrain development. It is evolutionarily conserved in vertebrates, humans, mice, chicks, and zebra fish. In addition, the amino acid sequence and most aspects of the embryonic gene pattern is conserved among vertebrates, further implicating its role in hindbrain development. When the Krox20 is deleted in mice, the protein coding ability of the Krox20 gene is diminished. These mice are unable to survive after birth and exhibit major hindbrain defects. These defects include but are not limited to defects in formation of cranial sensory ganglia, partial fusion of the trigeminal nerve (V) with the facial (VII) and auditory (VII) nerves, the proximal nerve roots coming off of these ganglia were disorganized and intertwined among one another as they entered the brainstem, and there was fusion of the glossopharyngeal (IX) nerve complex.

KLF10

Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.

NAB2

NGFI-A-binding protein 2 also known as EGR-1-binding protein 2 or melanoma-associated delayed early response protein (MADER) is a protein that in humans is encoded by the NAB2 gene.

KLF12

Krueppel-like factor 12 is a protein that in humans is encoded by the KLF12 gene.

ZNF146

Zinc finger protein OZF is a protein that in humans is encoded by the ZNF146 gene.

EGR3

Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.

ZHX3

Zinc fingers and homeoboxes protein 3 is a protein that in humans is encoded by the ZHX3 gene.

NAB1

NGFI-A-binding protein 1 is a protein that in humans is encoded by the NAB1 gene.

DPF2

Zinc finger protein ubi-d4 is a protein that in humans is encoded by the DPF2 gene.

RREB1

Ras-responsive element-binding protein 1 is a protein that in humans is encoded by the RREB1 gene.

ZFX

Zinc finger X-chromosomal protein is a protein that in mammals is encoded by the ZFX gene of the X chromosome.

ZBTB7B

Zinc finger and BTB domain-containing protein 7B is a protein that in humans is encoded by the ZBTB7B gene. ZFP67 is an early growth response gene that encodes a zinc finger-containing transcription factor that binds to the promoter regions of type I collagen genes and has a role in development.[supplied by OMIM]

ZNF44

Zinc finger protein 44 is a protein that in humans is encoded by the ZNF44 gene.

ZNF7

Zinc finger protein 7 is a protein that in humans is encoded by the ZNF7 gene.

ZNF19

Zinc finger protein 19 is a protein that in humans is encoded by the ZNF19 gene.

ZNF33B

Zinc finger protein 33B is a protein that in humans is encoded by the ZNF33B gene.

CTCFL

Transcriptional repressor CTCFL also known as BORIS is a protein that in humans is encoded by the CTCFL gene.

ZNF133

Zinc finger protein 133 is a protein that in humans is encoded by the ZNF133 gene.

ZNF436

Zinc finger protein 436 is a protein that in humans is encoded by the ZNF436 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135625 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071341 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: early growth response 4".

Further reading