ARID3B

ARID3B
Identifiers
Aliases	ARID3B , BDP, DRIL2, AT-rich interaction domain 3B
External IDs	OMIM: 612457 MGI: 1930768 HomoloGene: 4721 GeneCards: ARID3B
Gene location (Human) Chr. Chromosome 15 (human) [1] Band 15q24.1 Start 74,541,206 bp [1] End 74,598,131 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 B Start 57,697,636 bp [2] End 57,744,076 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte blood secondary oocyte bone marrow cells placenta cardia monocyte embryo external globus pallidus saphenous vein Top expressed in yolk sac mirror secondary oocyte primitive streak spermatid spermatocyte seminiferous tubule thymus blood spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleoplasm nucleus Biological process regulation of transcription, DNA-templated transcription by RNA polymerase II transcription, DNA-templated positive regulation of transcription by RNA polymerase II biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10620 56380 Ensembl ENSG00000179361 ENSMUSG00000004661 UniProt Q8IVW6 Q9Z1N7 RefSeq (mRNA) NM_001307939 NM_006465 NM_019689 NM_001379353 RefSeq (protein) NP_001294868 NP_006456 NP_062663 NP_001366282 Location (UCSC) Chr 15: 74.54 – 74.6 Mb Chr 9: 57.7 – 57.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene. ^[5]

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000179361 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004661 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: ARID3B AT rich interactive domain 3B (BRIGHT-like)".

Further reading

• Kortschak RD, Tucker PW, Saint R (Jun 2000). "ARID proteins come in from the desert". Trends in Biochemical Sciences. 25 (6): 294–9. doi:10.1016/S0968-0004(00)01597-8. PMID   10838570.
• Numata S, Claudio PP, Dean C, Giordano A, Croce CM (Aug 1999). "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product". Cancer Research. 59 (15): 3741–7. PMID   10446990.
• Liao TT, Hsu WH, Ho CH, Hwang WL, Lan HY, Lo T, Chang CC, Tai SK, Yang MH (2016). "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex". Cell Reports. 14 (3): 520–33. doi: 10.1016/j.celrep.2015.12.064 . PMID   26776511.

External links

• ARID3B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human ARID3B genome location and ARID3B gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.