| ZNF366 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | ZNF366 , DCSCRIPT, zinc finger protein 366, DC-SCRIPT | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 610159 MGI: 2178429 HomoloGene: 17637 GeneCards: ZNF366 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Zinc finger protein 366, also known as DC-SCRIPT (Dendritic cell-specific transcript), is a protein that in humans is encoded by the ZNF366 gene. [5] The ZNF366 gene was first identified in a DNA comparison study between 85 kb of Fugu rubripes sequence containing 17 genes with its homologous loci in the human draft genome. [6]
In 2006, DC-SCRIPT was isolated and characterized in human monocyte-derived dendritic cells (mo-DCs). [7]
DC-SCRIPT contains a DNA-binding domain (11 C2H2 zinc (Zn) fingers), flanked by a proline-rich and an acidic region, which can interact with C-terminal-binding protein 1 (CtBP1), a global corepressor. In the immune system of both mice and humans, DC-SCRIPT was found to be specifically expressed in dendritic cells (DCs). [8]
In COS-1 cells, DC-SCRIPT was shown to interact with the estrogen receptor DNA-binding domain (ERDBD) and represses ER activity through the association with RIP140, CtBP and histone deacetylases. [9]
In DCs, DC-SCRIPT was found to be highly expressed in type one conventional DCs (cDC1s) under the control of PU.1. [10] The presence of DC-SCRIPT is important for the cDC1s lineage specification via maintaining Interferon regulatory factor 8 (IRF8) expression. The DC-SCRIPT deficient cDC1s had impaired capacity to capture and present cell-associated antigens and to secrete IL-12p40. [11]
In 2010, it was shown that DC-SCRIPT can act as a coregulator of multiple nuclear receptors having opposite effects on type I vs type II NRs. DC-SCRIPT is able to repress ER and PR mediated transcription, whereas it can activate transcription mediated by RAR and PPAR. In the same study, it was shown that breast tumor tissue expresses lower levels of DC-SCRIPT than normal breast tissue from the same patient and that DC-SCRIPT mRNA expression is an independent prognostic factor for good survival of breast cancer patients with estrogen receptor- and/or progesterone receptor-positive tumors. [12]
The "C" sub-family of chemokine receptors contains only one member: XCR1, the receptor for XCL1 and XCL2.
Tripartite motif-containing 28 (TRIM28), also known as transcriptional intermediary factor 1β (TIF1β) and KAP1, is a protein that in humans is encoded by the TRIM28 gene.
PR domain zinc finger protein 2 is a protein that in humans is encoded by the PRDM2 gene.
Zinc finger homeobox protein 3 is a protein that in humans is encoded by the ZFHX3 gene.
Krueppel-like factor 10 is a protein that in humans is encoded by the KLF10 gene.
Breast cancer anti-estrogen resistance protein 3 is a protein that in humans is encoded by the BCAR3 gene.
Zinc transporter SLC39A7 (ZIP7), also known as solute carrier family 39 member 7, is a protein that in humans is encoded by the SLC39A7 gene. Its fruit fly orthologue is Catsup.
Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.
Zinc finger protein 274 is a protein that in humans is encoded by the ZNF274 gene.
Zinc finger protein 219 is a protein that in humans is encoded by the ZNF219 gene.
Protein Jade-3 is a protein that in humans is encoded by the PHF16 gene.
Zinc finger protein 267 is a protein that in humans is encoded by the ZNF267 gene.
Tripartite motif-containing protein 16 is a protein that in humans is encoded by the TRIM16 gene.
Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.
Breast carcinoma amplified sequence 3, also known as BCAS3, is a protein which in humans is encoded by the BCAS3 gene. BCAS3 is a gene that is amplified and overexpressed in breast cancer cells.
Cip1-interacting zinc finger protein is a protein that in humans is encoded by the CIZ1 gene.
RING finger protein 115 is a protein, that in humans, is encoded by the RNF115 gene.
Zinc finger protein 160 is a protein that, in humans, is encoded by the ZNF160 gene.
Zinc finger, X-linked, duplicated family member C (ZXDC) is a human CIITA-binding protein involved in the activation of major histocompatibility complex (MHC) class I and II. For binding to occur, ZXDC must form an oligomeric complex with another copy of itself or with ZXDA, a related protein. ZXDC is activated by sumoylation, a post-translational modification. ZXDC plays a role in controlling immunological responses, cancer formation and progression, and cell proliferation, differentiation, and survival.
C8orf48 is a protein that in humans is encoded by the C8orf48 gene. C8orf48 is a nuclear protein specifically predicted to be located in the nuclear lamina. C8orf48 has been found to interact with proteins that are involved in the regulation of various cellular responses like gene expression, protein secretion, cell proliferation, and inflammatory responses. This protein has been linked to breast cancer and papillary thyroid carcinoma.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
