ZNF638

ZNF638
Identifiers
Aliases	ZNF638 , NP220, ZFML, Zfp638, zinc finger protein 638
External IDs	OMIM: 614349 MGI: 1203484 HomoloGene: 7447 GeneCards: ZNF638
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p13.2 Start 71,276,561 bp [1] End 71,435,069 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 C3 Start 83,844,091 bp [2] End 83,966,532 bp [2]
RNA expression pattern Bgee Top expressed in corpus callosum kidney stomach lung Achilles tendon heart sural nerve cerebellar hemisphere More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding DNA binding zinc ion binding double-stranded DNA binding nucleic acid binding RNA binding Cellular component cytoplasm nuclear speck intracellular membrane-bounded organelle nucleus nucleoplasm Biological process regulation of transcription, DNA-templated transcription, DNA-templated RNA splicing Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27332	18139
Ensembl	ENSG00000075292	ENSMUSG00000030016
UniProt	Q14966	Q61464
RefSeq (mRNA)	NM_001014972 NM_001252612 NM_001252613 NM_014497	NM_001166371 NM_008717 NM_001355284 NM_001355285 NM_001355286
RefSeq (protein)	NP_001014972 NP_001239541 NP_001239542 NP_055312	NP_001159843 NP_032743 NP_001342213 NP_001342214 NP_001342215
Location (UCSC)	Chr 2: 71.28 – 71.44 Mb	Chr 6: 83.84 – 83.97 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc finger protein 638 is a protein that in humans is encoded by the ZNF638 gene. ^{[5] [6]}

The protein encoded by this gene is a nucleoplasmic protein. It binds cytidine-rich sequences in double-stranded DNA. This protein has three types of domains: MH1, MH2 (repeated three times) and MH3. It is associated with packaging, transferring, or processing transcripts. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. ^[6]

Interactions

ZNF638 has been shown to interact with FHL2. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000075292 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030016 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Inagaki H, Matsushima Y, Nakamura K, Ohshima M, Kadowaki T, Kitagawa Y (Jul 1996). "A large DNA-binding nuclear protein with RNA recognition motif and serine/arginine-rich domain". J Biol Chem. 271 (21): 12525–31. doi: 10.1074/jbc.271.21.12525 . PMID   8647861.
6. "Entrez Gene: ZNF638 zinc finger protein 638".
7. Ng, Enders Kai On; Chan Kwok Keung; Wong Chi Hang; Tsui Stephen Kwok Wing; Ngai Sai Ming; Lee Simon Ming Yuen; Kotaka Masayo; Lee Cheuk Yu; Waye Mary Miu Yee; Fung Kwok Pui (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. United States. 84 (3): 556–66. doi:10.1002/jcb.10041. ISSN   0730-2312. PMID   11813260. S2CID   2842198.

Further reading

• Okumara K, Nogami M, Matsushima Y, et al. (1998). "Mapping of human DNA-binding nuclear protein (NP220) to chromosome band 2p13.1-p13.2 and its relation to matrin 3". Biosci. Biotechnol. Biochem. 62 (8): 1640–2. doi: 10.1271/bbb.62.1640 . PMID   9757574.
• Eichmuller S, Usener D, Dummer R, et al. (2001). "Serological detection of cutaneous T-cell lymphoma-associated antigens". Proc. Natl. Acad. Sci. U.S.A. 98 (2): 629–34. doi: 10.1073/pnas.021386498 . PMC   14639 . PMID   11149944.
• Ng EK, Chan KK, Wong CH, et al. (2002). "Interaction of the heart-specific LIM domain protein, FHL2, with DNA-binding nuclear protein, hNP220". J. Cell. Biochem. 84 (3): 556–66. doi:10.1002/jcb.10041. PMID   11813260. S2CID   2842198.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–95. doi: 10.1074/mcp.M500021-MCP200 . PMID   15778465.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. Bibcode:2005Natur.434..724H. doi: 10.1038/nature03466 . PMID   15815621.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi: 10.1073/pnas.0507066103 . PMC   1459365 . PMID   16565220.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• ZNF638+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.