Liver receptor homolog-1

NR5A2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RWV, 1YOK, 1YUC, 1ZDU, 2A66, 3PLZ, 3TX7, 4DOR, 4DOS, 4IS8, 4ONI, 4PLD, 4PLE
Identifiers
Aliases	NR5A2 , B1F, B1F2, CPF, FTF, FTZ-F1, FTZ-F1beta, LRH-1, LRH1, hB1F-2, nuclear receptor subfamily 5 group A member 2
External IDs	OMIM: 604453 MGI: 1346834 HomoloGene: 20827 GeneCards: NR5A2
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q32.1 Start 200,027,614 bp [1] End 200,177,420 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 59.98 cM|1 E4 Start 136,770,309 bp [2] End 136,888,186 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in body of pancreas islet of Langerhans jejunal mucosa liver right lobe of liver duodenum rectum pancreatic ductal cell gallbladder visceral pleura Top expressed in cumulus cell ovarian follicle left lobe of liver left colon exocrine pancreas secondary oocyte morula crypt of lieberkuhn of small intestine Paneth cell jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription factor activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific chromatin binding transcription cis-regulatory region binding metal ion binding steroid hormone receptor activity nuclear receptor activity protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding double-stranded DNA binding phospholipid binding lipid binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component cytoplasm nucleoplasm RNA polymerase II transcription regulator complex nucleus Biological process regulation of transcription, DNA-templated epithelial cell differentiation pancreas morphogenesis bile acid metabolic process transcription, DNA-templated positive regulation of transcription, DNA-templated intracellular receptor signaling pathway regulation of cell population proliferation tissue development hormone-mediated signaling pathway cholesterol homeostasis positive regulation of viral genome replication transcription initiation from RNA polymerase II promoter steroid hormone mediated signaling pathway positive regulation of transcription by RNA polymerase II homeostatic process calcineurin-mediated signaling cellular response to leukemia inhibitory factor embryo development ending in birth or egg hatching Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2494 26424 Ensembl ENSG00000116833 ENSMUSG00000026398 UniProt O00482 P45448 RefSeq (mRNA) NM_001276464 NM_003822 NM_205860 NM_001159769 NM_030676 RefSeq (protein) NP_001263393 NP_003813 NP_995582 NP_001153241 NP_109601 Location (UCSC) Chr 1: 200.03 – 200.18 Mb Chr 1: 136.77 – 136.89 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The liver receptor homolog-1 (LRH-1) also known as totipotency pioneer factor NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene. ^{[5] [6]} LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis. ^{[7] [8] [9] [10]}

LRH-1 is important for maintaining pluripotence of stem cells during embryonic development. ^{[11] [10]}

Interactions

Liver receptor homolog-1 has been shown to interact with the small heterodimer partner. ^{[12] [13]}

References

1. GRCh38: Ensembl release 89: ENSG00000116833 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026398 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Bernier D, Thomassin H, Allard D, Guertin M, Hamel D, Blaquière M, Beauchemin M, LaRue H, Estable-Puig M, Bélanger L (Mar 1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Molecular and Cellular Biology. 13 (3): 1619–33. doi:10.1128/mcb.13.3.1619. PMC   359474 . PMID   7680097.
6. Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenetics and Cell Genetics. 82 (3–4): 269–70. doi:10.1159/000015116. PMID   9858833. S2CID   46813832.
7. Fayard E, Auwerx J, Schoonjans K (May 2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends in Cell Biology. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID   15130581.
8. Luo Y, Liang CP, Tall AR (Jul 2001). "The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor". The Journal of Biological Chemistry. 276 (27): 24767–73. doi: 10.1074/jbc.M100912200 . PMID   11331284.
9. Nitta M, Ku S, Brown C, Okamoto AY, Shan B (Jun 1999). "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6660–5. Bibcode:1999PNAS...96.6660N. doi: 10.1073/pnas.96.12.6660 . PMC   21971 . PMID   10359768.
10. Gassler J, Kobayashi W, Gáspár I, Ruangroengkulrith S, Mohanan A, Gómez Hernández L, Kravchenko P, Kümmecke M, Lalic A, Rifel N, Ashburn RJ, Zaczek M, Vallot A, Cuenca Rico L, Ladstätter S, Tachibana K (Nov 2022). "Zygotic genome activation by the totipotency pioneer factor Nr5a2". Science. 378 (6626): 1305–1315. doi:10.1126/science.abn7478. PMID   36423263.
11. Gu P, Goodwin B, Chung AC, Xu X, Wheeler DA, Price RR, Galardi C, Peng L, Latour AM, Koller BH, Gossen J, Kliewer SA, Cooney AJ (May 2005). "Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development". Molecular and Cellular Biology. 25 (9): 3492–505. doi:10.1128/MCB.25.9.3492-3505.2005. PMC   1084298 . PMID   15831456.
12. Brendel C, Schoonjans K, Botrugno OA, Treuter E, Auwerx J (Sep 2002). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Molecular Endocrinology. 16 (9): 2065–76. doi: 10.1210/me.2001-0194 . PMID   12198243.
13. Lee YK, Moore DD (Jan 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of Biological Chemistry. 277 (4): 2463–7. doi: 10.1074/jbc.M105161200 . PMID   11668176.

Further reading

• Wong M, Ramayya MS, Chrousos GP, Driggers PH, Parker KL (Oct 1996). "Cloning and sequence analysis of the human gene encoding steroidogenic factor 1". Journal of Molecular Endocrinology. 17 (2): 139–47. doi:10.1677/jme.0.0170139. PMID   8938589.
• Li M, Xie YH, Kong YY, Wu X, Zhu L, Wang Y (Oct 1998). "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus". The Journal of Biological Chemistry. 273 (44): 29022–31. doi: 10.1074/jbc.273.44.29022 . PMID   9786908.
• Nitta M, Ku S, Brown C, Okamoto AY, Shan B (Jun 1999). "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene". Proceedings of the National Academy of Sciences of the United States of America. 96 (12): 6660–5. Bibcode:1999PNAS...96.6660N. doi: 10.1073/pnas.96.12.6660 . PMC   21971 . PMID   10359768.
• Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewer SA (Sep 2000). "A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis". Molecular Cell. 6 (3): 517–26. doi: 10.1016/S1097-2765(00)00051-4 . PMID   11030332.
• Wang ZN, Bassett M, Rainey WE (Oct 2001). "Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase". Journal of Molecular Endocrinology. 27 (2): 255–8. doi: 10.1677/jme.0.0270255 . PMID   11564608.
• Zhang CK, Lin W, Cai YN, Xu PL, Dong H, Li M, Kong YY, Fu G, Xie YH, Huang GM, Wang Y (Aug 2001). "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene". Gene. 273 (2): 239–49. doi:10.1016/S0378-1119(01)00586-8. PMID   11595170.
• Lee YK, Moore DD (Jan 2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of Biological Chemistry. 277 (4): 2463–7. doi: 10.1074/jbc.M105161200 . PMID   11668176.
• Clyne CD, Speed CJ, Zhou J, Simpson ER (Jun 2002). "Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes". The Journal of Biological Chemistry. 277 (23): 20591–7. doi: 10.1074/jbc.M201117200 . PMID   11927588.
• Brendel C, Gelman L, Auwerx J (Jun 2002). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Molecular Endocrinology. 16 (6): 1367–77. doi: 10.1210/mend.16.6.0843 . PMID   12040021.
• Sirianni R, Seely JB, Attia G, Stocco DM, Carr BR, Pezzi V, Rainey WE (Sep 2002). "Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes". The Journal of Endocrinology. 174 (3): R13–7. doi: 10.1677/joe.0.174R013 . PMID   12208674.
• Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA (Jun 2003). "Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1". Molecular Cell. 11 (6): 1575–85. doi: 10.1016/S1097-2765(03)00236-3 . PMID   12820970.
• Privalsky ML (Jul 2003). "Activation incarnate". Developmental Cell. 5 (1): 1–2. doi: 10.1016/S1534-5807(03)00196-5 . PMID   12852843.
• Fayard E, Schoonjans K, Annicotte JS, Auwerx J (Sep 2003). "Liver receptor homolog 1 controls the expression of carboxyl ester lipase". The Journal of Biological Chemistry. 278 (37): 35725–31. doi: 10.1074/jbc.M302370200 . PMID   12853459.
• Annicotte JS, Fayard E, Swift GH, Selander L, Edlund H, Tanaka T, Kodama T, Schoonjans K, Auwerx J (Oct 2003). "Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development". Molecular and Cellular Biology. 23 (19): 6713–24. doi:10.1128/MCB.23.19.6713-6724.2003. PMC   193920 . PMID   12972592.
• Peng N, Kim JW, Rainey WE, Carr BR, Attia GR (Dec 2003). "The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II". The Journal of Clinical Endocrinology and Metabolism. 88 (12): 6020–8. doi:10.1210/jc.2003-030880. PMID   14671206.
• Cai YN, Zhou Q, Kong YY, Li M, Viollet B, Xie YH, Wang Y (Dec 2003). "LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication". Cell Research. 13 (6): 451–8. doi: 10.1038/sj.cr.7290187 . PMID   14728801.
• Saxena D, Safi R, Little-Ihrig L, Zeleznik AJ (Aug 2004). "Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation". Endocrinology. 145 (8): 3821–9. doi: 10.1210/en.2004-0423 . PMID   15117876.

External links

• NR5A2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)