SOX15

SOX15
Identifiers
Aliases	SOX15 , SOX20, SOX26, SOX27, SRY-box 15, SRY-box transcription factor 15
External IDs	OMIM: 601297 MGI: 98363 HomoloGene: 74586 GeneCards: SOX15
Gene location (Human)
Chr.	Chromosome 17 (human)
End	7,590,094 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	69,547,553 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; skin of abdomen; ; vagina; ; epithelium of esophagus; ; Brodmann area 10; ; cingulate gyrus; ; gums; ; vulva; ; gastric mucosa;
	Top expressed in
	morula; ; corneal stroma; ; lip; ; secondary oocyte; ; esophagus; ; entorhinal cortex; ; blastocyst; ; urethra; ; female urethra; ; male urethra;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding ; DNA-binding transcription factor activity ; chromatin binding ; protein binding ; protein heterodimerization activity ; DNA-binding transcription factor activity, RNA polymerase II-specific ; DNA-binding transcription activator activity, RNA polymerase II-specific ;
Cellular component	cytoplasm ; nucleus ;
Biological process	positive regulation of myoblast proliferation ; cell differentiation ; male gonad development ; regulation of transcription, DNA-templated ; positive regulation of satellite cell activation involved in skeletal muscle regeneration ; negative regulation of striated muscle tissue development ; regulation of transcription by RNA polymerase II ; positive regulation of G0 to G1 transition ; negative regulation of transcription by RNA polymerase II ; chromatin organization ; myoblast development ; skeletal muscle tissue regeneration ; positive regulation of transcription by RNA polymerase II ; central nervous system development ; neuron differentiation ;
	Sources:Amigo / QuickGO
Orthologs
	6665
	20670
	ENSG00000129194
	ENSMUSG00000041287
	O60248
	P43267
	NM_006942
	NM_009235
	NP_008873
	NP_033261
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated September 08, 2022

Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.^[5]^[6]^[7]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.^[7]

Related Research Articles

Sex-determining region Y protein (SRY), or Testis-determining factor (TDF), is a DNA-binding protein encoded by the SRY gene that is responsible for the initiation of male sex determination in therian mammals. SRY is an intronless sex-determining gene on the Y chromosome. Mutations in this gene lead to a range of disorders of sex development with varying effects on an individual's phenotype and genotype.

SOX genes encode a family of transcription factors that bind to the minor groove in DNA, and belong to a super-family of genes characterized by a homologous sequence called the HMG-box. This HMG box is a DNA binding domain that is highly conserved throughout eukaryotic species. Homologues have been identified in insects, nematodes, amphibians, reptiles, birds and a range of mammals. However, HMG boxes can be very diverse in nature, with only a few amino acids being conserved between species.

Cartilage associated protein is a protein that in humans is encoded by the CRTAP gene.

Testis-specific Y-encoded protein 1 is a protein that in humans is encoded by the TSPY1 gene.

Transcription factor SOX-4 is a protein that in humans is encoded by the SOX4 gene.

Transcription factor SOX-3 is a protein that in humans is encoded by the SOX3 gene. This gene encodes a member of the SOX family of transcription factors involved in the regulation of embryonic brain development and in determination of cell fate. The encoded protein acts as a transcriptional activator.

Transcription factor SOX-5 is a protein that in humans is encoded by the SOX5 gene.

Transcription factor SOX-18 is a protein that in humans is encoded by the SOX18 gene.

Homeobox protein Hox-D1 is a protein that in humans is encoded by the HOXD1 gene.

Proline-rich protein PRCC is a protein that, in humans, is encoded by the PRCC gene.

Transcription factor SOX-11 is a protein that in humans is encoded by the SOX11 gene.

Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.

Developmentally-regulated GTP-binding protein 2 is a protein that in humans is encoded by the DRG2 gene.

Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.

Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.

SOX12 is a protein that in humans is encoded by the SOX12 gene. Sox12 belongs to the SoxC group of Sox family of transcription factors, together with Sox4 and Sox11. Sox12-null knockout mice appear normal, unlike Sox4 or Sox11 knockout mice. This probably comes from functional redundancy with Sox4 and Sox11. Sox12 is a weaker activator than both Sox4 and Sox11 in mouse.

Transcription factor SOX-14 is a protein that in humans is encoded by the SOX14 gene.

Transcription factor SOX-21 is a protein that in humans is encoded by the SOX21 gene. It is a member of the Sox gene family of transcription factors.

Homeobox protein Hox-A2 is a protein that in humans is encoded by the HOXA2 gene.

Short-stature homeobox 2, also known as homeobox protein Og12X or paired-related homeobox protein SHOT, is a protein that in humans is encoded by the SHOX2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000129194 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041287 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Meyer J, Wirth J, Held M, Schempp W, Scherer G (Jan 1997). "SOX20, a new member of the SOX gene family, is located on chromosome 17p13". Cytogenet Cell Genet. 72 (2–3): 246–9. doi:10.1159/000134200. PMID 8978787.
↑ Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625. S2CID 46849443.
1 2 "Entrez Gene: SOX15 SRY (sex determining region Y)-box 15".

Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell. 3 (2): 167–70. doi: 10.1016/S1534-5807(02)00223-X . PMID 12194848.
Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692 . PMID 8332506.
Hiraoka Y, Ogawa M, Sakai Y, et al. (1998). "Isolation and expression of a human SRY-related cDNA hSOX20". Biochim. Biophys. Acta. 1396 (2): 132–7. doi:10.1016/s0167-4781(97)00186-3. PMID 9540826.
Cremazy F, Soullier S, Berta P, Jay P (1998). "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR". FEBS Lett. 438 (3): 311–4. doi: 10.1016/S0014-5793(98)01294-0 . PMID 9827568. S2CID 551497.
Vujić M, Rajić T, Goodfellow PN, Stevanović M (1999). "cDNA characterization and high resolution mapping of the human SOX20 gene". Mamm. Genome. 9 (12): 1059–61. doi:10.1007/s003359900925. PMID 9880678. S2CID 792477.
Miyashita A, Shimizu N, Endo N, et al. (1999). "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11". Gene. 237 (1): 53–60. doi:10.1016/S0378-1119(99)00301-7. PMID 10524236.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000129194 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000041287 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8978787-5] Meyer J, Wirth J, Held M, Schempp W, Scherer G (Jan 1997). "SOX20, a new member of the SOX gene family, is located on chromosome 17p13". Cytogenet Cell Genet. 72 (2–3): 246–9. doi:10.1159/000134200. PMID 8978787.

[pmid9730625-6] Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625. S2CID 46849443.

[entrez-7] 1 2 "Entrez Gene: SOX15 SRY (sex determining region Y)-box 15".

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SOX15

Contents

See also

Related Research Articles

References

Further reading