TFCP2

Last updated
TFCP2
Identifiers
Aliases TFCP2 , LBP1C, LSF, LSF1D, SEF, TFCP2C, transcription factor CP2
External IDs OMIM: 189889 MGI: 98509 HomoloGene: 4134 GeneCards: TFCP2
Orthologs
SpeciesHumanMouse
Entrez

7024

21422

Ensembl

ENSG00000135457

ENSMUSG00000009733

UniProt

Q12800

Q9ERA0

RefSeq (mRNA)

NM_005653
NM_001173452
NM_001173453

NM_001289603
NM_033476
NM_001355497

RefSeq (protein)

NP_001166923
NP_001166924
NP_005644

NP_001276532
NP_258437
NP_001342426

Location (UCSC) Chr 12: 51.09 – 51.17 Mb Chr 15: 100.4 – 100.45 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Alpha-globin transcription factor CP2 is a protein that in humans is encoded by the TFCP2 gene. [5] [6]

Contents

TFCP2 is also called Late SV40 factor (LSF) and it is induced by well known oncogene AEG-1. [7] LSF also acts as an oncogene in hepatocellular carcinoma. [8] LSF enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). [9]

Along with its main oncogene function in hepatocellular carcinoma (HCC) it plays multifaceted role in chemoresistance, epithelial-mesenchymal transition (EMT), allergic response, inflammation and Alzheimer's disease. [8] [10] The small molecule FQI1 (factor quinolinone inhibitor 1) prevents LSF from binding to HCC DNA which results in HCC cell death. [8] [10] [11]

Interactions

TFCP2 has been shown to interact with APBB1 [12] and RNF2. [13]

Related Research Articles

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000135457 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000009733 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Swendeman SL, Spielholz C, Jenkins NA, Gilbert DJ, Copeland NG, Sheffery M (Apr 1994). "Characterization of the genomic structure, chromosomal location, promoter, and development expression of the alpha-globin transcription factor CP2". The Journal of Biological Chemistry. 269 (15): 11663–71. doi: 10.1016/S0021-9258(19)78176-9 . PMID   8157699.
  6. ↑ "Entrez Gene: TFCP2 transcription factor CP2".
  7. ↑ Yoo BK, Gredler R, Vozhilla N, Su ZZ, Chen D, Forcier T, Shah K, Saxena U, Hansen U, Fisher PB, Sarkar D (Aug 2009). "Identification of genes conferring resistance to 5-fluorouracil". Proceedings of the National Academy of Sciences of the United States of America. 106 (31): 12938–43. Bibcode:2009PNAS..10612938Y. doi: 10.1073/pnas.0901451106 . PMC   2722317 . PMID   19622726.
  8. 1 2 3 Yoo BK, Emdad L, Gredler R, Fuller C, Dumur CI, Jones KH, Jackson-Cook C, Su ZZ, Chen D, Saxena UH, Hansen U, Fisher PB, Sarkar D (May 2010). "Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 107 (18): 8357–62. Bibcode:2010PNAS..107.8357Y. doi: 10.1073/pnas.1000374107 . PMC   2889542 . PMID   20404171.
  9. ↑ Santhekadur PK, Gredler R, Chen D, Siddiq A, Shen XN, Das SK, Emdad L, Fisher PB, Sarkar D (Jan 2012). "Late SV40 factor (LSF) enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP-9)". The Journal of Biological Chemistry. 287 (5): 3425–32. doi: 10.1074/jbc.M111.298976 . PMC   3270996 . PMID   22167195.
  10. 1 2 Santhekadur PK, Rajasekaran D, Siddiq A, Gredler R, Chen D, Schaus SC, Hansen U, Fisher PB, Sarkar D (2012). "The transcription factor LSF: a novel oncogene for hepatocellular carcinoma" (PDF). Am J Cancer Res. 2 (3): 269–285. PMC   3365805 . PMID   22679558.
  11. ↑ Grant TJ, Bishop JA, Christadore LM, Barot G, Chin HG, Woodson S, Kavouris J, Siddiq A, Gredler R, Shen XN, Sherman J, Meehan T, Fitzgerald K, Pradhan S, Briggs LA, Andrews WH, Sarkar D, Schaus SE, Hansen U (Mar 2012). "Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene addiction to LSF in hepatocellular carcinoma". Proceedings of the National Academy of Sciences of the United States of America. 109 (12): 4503–8. Bibcode:2012PNAS..109.4503G. doi: 10.1073/pnas.1121601109 . PMC   3311344 . PMID   22396589.
  12. ↑ Zambrano N, Minopoli G, de Candia P, Russo T (Aug 1998). "The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1". The Journal of Biological Chemistry. 273 (32): 20128–33. doi: 10.1074/jbc.273.32.20128 . PMID   9685356.
  13. ↑ Tuckfield A, Clouston DR, Wilanowski TM, Zhao LL, Cunningham JM, Jane SM (Mar 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of developmental transcription factors". Molecular and Cellular Biology. 22 (6): 1936–46. doi:10.1128/MCB.22.6.1936-1946.2002. PMC   135618 . PMID   11865070.

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