Mir-711 microRNA precursor family

Last updated
mir-711
Identifiers
Symbolmir-711
Rfam RF01923
miRBase family MIPF0000748
Other data
RNA type microRNA
Domain(s) Eukaryota;
PDB structures PDBe

In molecular biology mir-711 microRNA is a short RNA molecule. MicroRNAs function to regulate the expression levels of other genes by several mechanisms.

Contents

Diagnostic use in Cutaneous T-cell Lymphoma

miR-711 is able to distinguish between malignant cutaneous T-cell lymphomas and benign skin disorders with high accuracy. [1]

Hsp70.3 and Further Regulation

miR-711 has been found to target and suppress Heat Shock Protein 70.3 in vitro at a post-transcriptional level via its 3' untranslated region. [2] Ischaemic preconditioning brings about reduced miR-711 levels, with downregulated cardiac myocyte levels further dependent upon NF-kappa B.

See also

Related Research Articles

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References

  1. Ralfkiaer U, Hagedorn PH, Bangsgaard N, Løvendorf MB, Ahler CB, Svensson L, Kopp KL, Vennegaard MT, Lauenborg B, Zibert JR, Krejsgaard T, Bonefeld CM, Søkilde R, Gjerdrum LM, Labuda T, Mathiesen AM, Grønbæk K, Wasik MA, Sokolowska-Wojdylo M, Queille-Roussel C, Gniadecki R, Ralfkiaer E, Geisler C, Litman T, Woetmann A, Glue C, Røpke MA, Skov L, Odum N (November 2011). "Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)". Blood. 118 (22): 5891–900. doi:10.1182/blood-2011-06-358382. PMC   3342856 . PMID   21865341.
  2. Tranter M, Helsley RN, Paulding WR, McGuinness M, Brokamp C, Haar L, Liu Y, Ren X, Jones WK (August 2011). "Coordinated post-transcriptional regulation of Hsp70.3 gene expression by microRNA and alternative polyadenylation". The Journal of Biological Chemistry. 286 (34): 29828–37. doi: 10.1074/jbc.M111.221796 . PMC   3191024 . PMID   21757701.

Further reading