Aspergillus penicillioides

Last updated

Aspergillus penicillioides
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Fungi
Division: Ascomycota
Class: Eurotiomycetes
Order: Eurotiales
Family: Aspergillaceae
Genus: Aspergillus
Species:
A. penicillioides
Binomial name
Aspergillus penicillioides
Speg. (1896)
Synonyms

Aspergillus vitricola Ohtsuki (1962)

Aspergillus penicillioides is a species of fungus in the genus Aspergillus , and is among the most xerophilic fungi. [1]

Contents

Aspergillus penicillioides is typically found in indoor air, house dust, and on substrates with low water activity, such as dried food, papers affected by foxing, and inorganic objects such as binocular lenses. [2] The distribution of the fungus is worldwide; it has been found in bed dust from maritime temperate, Mediterranean, and tropical climates. [3] The abundance of the fungus is influenced by outdoor climate, with highest numbers found in tropics and lowest numbers in cool climates. Cool temperature tends to decrease number of A. penicillioides in house dust. [3]

A colony can arise from a single sexual or asexual spore under acidic conditions, [4] and its diameter ranges from less than a milliliter to several centimeters, depending on the size and composition of the substrate. [1] Germination of A. penicillioides was found to occur at lower water activity than growth. The lowest water activity for germination was 0.585. [5]

Taxonomy and phylogeny

Aspergillus penicillioides is included in the genus Aspergillus, section Restricti. Presumably because of the xerophilic character, Aspergillus restrictus was recognized by Charles Thom and Kenneth B. Raper as a Series within the group of Aspergillus glaucus . [6] Raper and Fennell later raised this Series to "A. restrictus Group". [6] Helmut Gams et al., renamed the taxa as Aspergillus Section Restricti in agreement with the Botanical Code. [6] Phylogenetic relationship of A. penicillioides and related teleomorph genera was inferred by 18S rDNA sequencing. A. penicillioides, A. restrictus, A. proliferans , five Eurotium teleomorphs represented by E. herbariorum and Edyuillia athecia were grouped together. [7] All these species have Q-9 as their major ubiquinone system. [7]

Growth and morphology

A. penicillioides has been cultivated on both Czapek yeast extract agar (CYA) plates and yeast extract sucrose agar (YES) plates. The growth morphology of the colonies can be seen in the pictures below.

History

Aspergillus penicillioides was named by Spegazzini in 1896. [8] The species was described from moldy sugarcane in Argentina, but it was not cultivated by Spegazzini. [9] The ex neotype strain CBS 540.65 was isolated from a human arm in Brazil that was misdiagnosed to lobomycosis. [7] The fungus was isolated from several compounds in different places. [9] Strain CBS 116.26 was isolated from sugar cane in Louisiana, and it was sent to Spegazzini and recognized by him to fit description of his species. Strain CBS 539.65 was isolated from a gun firing mechanism and CBS118.55 was isolated from a man in Netherlands. [6] Several other A. penicillioides strains were isolated from Indonesian dried fish in Australia and dried chili in Papua New Guinea. [7] ATCC 16905, extype of Aspergillus vitricola, was isolated from binocular lens in Japan by Torao Ohtsuki. [7]

Aspergillus penicillioides was erroneously identified to be the etiologic agent in a case of aspergilloma. The conidial structure and colony appearance indicated that it was an isolate of A. fumigatus . [7]

Description

Aspergillus penicillioides fails to grow or grows very poorly on Czapek medium at 25–26 °C with length never exceeding 2 to 3 mm. Colonies on Czapek's agar with 20% sucrose can reach length of 1–1.5 cm in 4 weeks at room temperature. [8] However, the fungus is thin and non-sporulating. Sporulation can occur by incubation at 33 °C. [8]

Colonies on malt extract agar grow a bit more rapidly than on standard Czapek's agar, producing microcolonies and a small number of conidial heads. [8] Occasionally, colonies can reach 5 mm in diameter. [6] Colonies on G25N agar can grow to 8–14 mm in diameter with wrinkled and floccose textures. There is moderate conidial production in loose columns. Color is dark green and reverse is pale to dark green. Colonies on CY20S agar have microcolonies up to 10 mm in diameter, but conidiophores are poorly formed. Color is also dull green and reverse is pale. [6] Colonies can grow rapidly on M40Y agar, obtaining length of 5 to 6 cm in 3 weeks at room temperature. [8] The fungus forms a "thin tough felt," sporulating in dark yellow-greenish shades. It can also grow as mycelium and have green color. [8] Reverse is uncolored to greenish brown or dark green, with color emphasized at colony center. [8] There is slight odor.

Conidial heads primarily arise from the substrate, but also produce some from aerial mycelium. [8] The fungus radiates when young and becomes columnar shaped with a diameter of 80 to 90 μm. Conidial heads arising from aerial mycelium are smaller and become columnar quicker. [8] Conidiophores arise from surface or aerial hyphae with the stipe's length ranging from 150 to 300 μm. The walls are thin, smooth and colorless. Vesicles are mostly 10-20 μm in diameter with a pear shape. Generally, two thirds of the vesicle area is fertile, bearing phialides ranging from 8-11 μm in length. Conidia are borne as elliptical and become globular shape when mature. The length is 4-5 μm in diameter with spiny and blackish wall. Perithecia is not found. [6]

Genome

There was great genetic variability detected among the A. penicillioides isolates, suggesting that some of these isolates might belong to new species. [2] At the DNA level, five strains of A. penicillioides were closely related with each other. However, A. penicillioides IFO 8155, originally described as A. vitricola , was distantly related to the other five strains, suggesting that IFO 8155 was not assigned to A. penicillioides and that the name A. vitricola should be used again. [10]

The genome of A. penicillioides was sequenced in 2016 as a part of the Aspergillus whole-genome sequencing project - a project dedicated to performing whole-genome sequencing of all members of the genus Aspergillus. [11] The genome assembly size was 26.40 Mbp. [11]

Impact on environment

Interaction with house dust mites

Aspergillus penicillioides facilitates the growth of house dust mites such as Dermatophagoides pteronyssinus . In laboratory cultures, the performance of fungus-free mites is poor, indicating a requirement of D. pteronyssinus for the fungus. D. pteronyssinus grew more rapidly when A. penicillioides was supplemented with dietary components, such as yeast and wheat germs, suggesting that the fungus has nutritious value for the mites. [12] Specifically, A. penicillioides predigests dandruff, destructs fats and keratin, which are the main components of mites' food. [13] The fungus also contributes its spores, vitamins B and D for D. pteronyssinus. [12] Conversely, A. penicillioides has adverse effects on D. pteronyssinus. The ratio between mite and fungi in a given concentration of substrate is important in determining growth dynamics of mites in culture. [14] When there are abundant substrates available, fungus captures substrates quicker than mites due to their shorter life cycle and greater reproductive potential. [14] This leads to the slow development of mites and higher mortality. [14] A. penicillioides can also alter the physical nature of substratum, which impedes mites' movement and increases food handling time. Female mites are more susceptible to these deleterious effects because they need to invest energy for egg production. [15]

Biodeterioration

Aspergillus penicillioides is known as a causal agent of foxing on paper art work and books. [16] It was once isolated from the brown spots on ancient Egyptian painting in Tutankhamun's tomb. [17] Some mechanisms for discoloration include colored pigments secreted by mycelia, maillard reaction, and enzyme production that causes chemical change in the paper. [18] Prevention treatment with pentachlorophenol failed to inhibit development of fungus.

Aspergillus penicillioides also caused mildew in cotton goods in Great Britain. In contrast, it was rarely found from deteriorated fabrics. [8] This inconsistency may be due to differences in isolation techniques. [8] Cigar culture molded with an Aspergillus was described to show gray green color. Appearance and measurements corresponded to A. penicillioides. Careful studies suggested that these cigar molds consisted mainly of A. penicillioides-like form. [9]

Health

Aspergillus penicillioides is a common indoor fungus in damp buildings where it has been associated with allergic rhinitis. Under high level of exposure to indoor fungus, an association was found between fungal concentration and development of allergic rhinitis. [19] Despite that this species was originally described from a skin infection, [20] the principle human exposure hazard is likely to be through the inhalation route. Products of mold growth, such as volatile organic metabolites and spores, may contribute to discomfort such as allergy and asthma. [21] Sustained growth of house dust mites by A. penicillioides can also be a health hazard. House dust mites can activate mast cells and T cells, which release mediators like prostaglandin and histamine that have multiple effects on epithelium. Dust mite-induced signals are then propagated through epithelium, which enhance allergic airway inflammation. [22] However, there is controversy on contribution of A. penicillioides to allergenicity of Dermatophagoides pteronyssinus. It was shown that allergen profiles of larval mites without this fungus are similar to adult mites with the fungus. [15] Fungus-free adult mites in experimental condition also had same allergen profiles when compared to the mites re-fed the fungus A. penicillioides. [15]

Sick building syndrome, in which air quality in building is deteriorated as a result of multiple factors, such as biological contamination by fungi, have been viewed as an important public health problem. [23] For example, A. penicillioides was isolated in all mattresses in Antwerp and Brussels. [3]

There are several ways to prevent and control manifestation of A. penicillioides and its biological contaminants. Fungal detector can be used to determine in advance whether a place is damp and supports fungal growth, which allow actions to be taken before contamination occurs. [24] The fungal detector encapsulating fungal spores is exposed to test site, and fungal response is measured. [24] Greatest response indicates the type of fungi that would contaminate the site. At 71% relative humidity, such as dry areas in homes, A. penicillioides showed greatest response and form many spores. [24] The formation of new spores indicate that life cycle of A. penicillioides is progressed to completion, and propagation of these new spores can lead to contamination. [24] A biosensor has also been used to detect volatile organic compounds, such as formaldehyde. [25] Formaldehyde is detected in air based on fungal growth inhibition, reflected by suppressed mycelium growth and absorbance. [25] This biosensor is advantageous in that it allows measuring of toxicity at lower cost than HPLC and GC/MS. However, it is difficult to identify the toxic substance and concentration of toxicity in a sample by this biosensor. [25] Some other prevention strategies are controlling liquid water, managing indoor condensation and selecting materials that minimize mold growth. [26]

Food contamination

Fungal infestation can spoil stored cereals, seeds, fruits, nuts, cocoa beans, and raw sugar. Infestation causes discoloration, loss of germinability, heating, mustiness, and decay. [27] The consequences are less worth of products and combustion. For example, coffee produced from moldy coffee beans lack aroma and flavor. Seeds and nuts are extracted to produce vegetable oils. However,A. penicillioides can increase free fatty acid content in the oil and produce bad taste. [27] The fungus growing on raw sugar can also invert sugar, which reduces sucrose and increases invert content. [27]

In 1955, Clyde Martin Christensen recognized that A. restrictus was able to grow on wheat at very low moisture level. Later, conidia of A. penicillioides have been found in processed wheat flour. [28] The propagules may be introduced to grain through exposure to airborne dusts during harvesting, storage and processing. [28] The presence of A. penicillioides may compromise the quality, nutrition and taste of bread. [28]

The spores of A. penicillioides are also found at filling-interface of chocolate truffles. [29] The water activity of filling is sufficient for fungal growth. The source of contamination may be from cocoa beans or from atmosphere during coating of truffle. [29]

Fungal bioconversion

2,4-Dichlorophenoxyacetic acid (2,4-D) is a common herbicide for controlling weeds, and it has been reported to be a mutagen. [30] A study has shown that A. penicillioides can remove 2,4-D from synthetic liquid media. [30] There was a lag period of 1 day, followed by 52% removal of 2,4-D from culture media by A. penicillioides. [30] The lag phase may be due to delay in growth, adverse conditions such as limiting nutrients, and enzyme proliferation specific for pollutants. After depletion of 2,4-D, the degradation efficiency declined and led to a plateau. [30]

Metabolite

The fungal metabolite, aurantiamide acetate, has been isolated from Aspergillus penicillioides, as a cathepsin inhibitor. [31] Cathepsin B and L play a crucial role in arthritic cartilage degeneration. The inhibitor of cathepsin isolated from this fungus can potentially be a therapy target for cartilage disorders. [31]

Industrial uses

Aspergillus penicillioides is used to treat petrochemical effluents with short-chain fatty acids (SCFA) containing acetic acid, propionic acid, isobutyric acid, n-butyric acid, isovaleric acid, and n-valeric acid. [32] When Aspergillus penicillioides was cultivated in a continuous flow reactor to treat a petrochemical effluent, more than 75% of COD and 80% of SCFA were removed. [32]

Related Research Articles

<span class="mw-page-title-main">Mold</span> Wooly, dust-like fungal structure or substance

A mold or mould is one of the structures that certain fungi can form. The dust-like, colored appearance of molds is due to the formation of spores containing fungal secondary metabolites. The spores are the dispersal units of the fungi. Not all fungi form molds. Some fungi form mushrooms; others grow as single cells and are called microfungi.

<i>Aspergillus niger</i> Species of fungus

Aspergillus niger is a mold classified within the Nigri section of the Aspergillus genus. The Aspergillus genus consists of common molds found throughout the environment within soil and water, on vegetation, in fecal matter, on decomposing matter, and suspended in the air. Species within this genus often grow quickly and can sporulate within a few days of germination. A combination of characteristics unique to A. niger makes the microbe invaluable to the production of many acids, proteins and bioactive compounds. Characteristics including extensive metabolic diversity, high production yield, secretion capability, and the ability to conduct post-translational modifications are responsible for A. niger's robust production of secondary metabolites. A. niger's capability to withstand extremely acidic conditions makes it especially important to the industrial production of citric acid.

<i>Aspergillus terreus</i> Species of fungus

Aspergillus terreus, also known as Aspergillus terrestris, is a fungus (mold) found worldwide in soil. Although thought to be strictly asexual until recently, A. terreus is now known to be capable of sexual reproduction. This saprotrophic fungus is prevalent in warmer climates such as tropical and subtropical regions. Aside from being located in soil, A. terreus has also been found in habitats such as decomposing vegetation and dust. A. terreus is commonly used in industry to produce important organic acids, such as itaconic acid and cis-aconitic acid, as well as enzymes, like xylanase. It was also the initial source for the drug mevinolin (lovastatin), a drug for lowering serum cholesterol.

Aspergillus ochraceus is a mold species in the genus Aspergillus known to produce the toxin ochratoxin A, one of the most abundant food-contaminating mycotoxins, and citrinin. It also produces the dihydroisocoumarin mellein. It is a filamentous fungus in nature and has characteristic biseriate conidiophores. Traditionally a soil fungus, has now began to adapt to varied ecological niches, like agricultural commodities, farmed animal and marine species. In humans and animals the consumption of this fungus produces chronic neurotoxic, immunosuppressive, genotoxic, carcinogenic and teratogenic effects. Its airborne spores are one of the potential causes of asthma in children and lung diseases in humans. The pig and chicken populations in the farms are the most affected by this fungus and its mycotoxins. Certain fungicides like mancozeb, copper oxychloride, and sulfur have inhibitory effects on the growth of this fungus and its mycotoxin producing capacities.

<i>Wallemia sebi</i> Species of fungus

Wallemia sebi is a xerophilic fungus of the phylum Basidiomycota.

<i>Aspergillus versicolor</i> Species of fungus

Aspergillus versicolor is a slow-growing species of filamentous fungus commonly found in damp indoor environments and on food products. It has a characteristic musty odor associated with moldy homes and is a major producer of the hepatotoxic and carcinogenic mycotoxin sterigmatocystin. Like other Aspergillus species, A. versicolor is an eye, nose, and throat irritant.

Aspergillus restrictus is a species of fungus in the genus Aspergillus. It is from the Restricti section. The species was first described in 1931. It is xerophilic, frequently found in house dust. Studies have suggested that it is an allergen implicated in asthma. In 2016, the genome of A. restrictus was sequenced as a part of the Aspergillus whole-genome sequencing project - a project dedicated to performing whole-genome sequencing of all members of the genus Aspergillus. The genome assembly size was 23.26 Mbp.

<i>Aspergillus candidus</i> Species of fungus

Aspergillus candidus is a white-spored species of fungus in the genus Aspergillus. Despite its lack of pigmentation, it is closely related to the most darkly-pigmented aspergilli in the Aspergillus niger group. It is a common soil fungus worldwide and is known as a contaminant of a wide array of materials from the indoor environment to foods and products. It is an uncommon agent of onychomycosis and aspergillosis. The species epithet candidus (L.) refers to the white pigmentation of colonies of this fungus. It is from the Candidi section. The fungi in the Candidi section are known for their white spores. It has been isolated from wheat flour, djambee, and wheat grain.

<i>Penicillium digitatum</i> Species of fungus

Penicillium digitatum is a mesophilic fungus found in the soil of citrus-producing areas. It is a major source of post-harvest decay in fruits and is responsible for the widespread post-harvest disease in Citrus fruit known as green rot or green mould. In nature, this necrotrophic wound pathogen grows in filaments and reproduces asexually through the production of conidiophores and conidia. However, P. digitatum can also be cultivated in the laboratory setting. Alongside its pathogenic life cycle, P. digitatum is also involved in other human, animal and plant interactions and is currently being used in the production of immunologically based mycological detection assays for the food industry.

Aspergillus unguis is a species of fungus in the genus Aspergillus, and the asexual state (anamorph) of Emericella unguis. Aspergillus unguis is a filamentous soil-borne fungus found on decomposing plant matter and other moist substrates including with building materials and household dust. Aspergillus unguis occurs mainly in tropical and subtropical soils but has also been isolated from various marine and aquatic habitats. The species was first isolated in 1935 by Weill and L. Gaudin. Historically, A. unguis was assigned to the A. nidulans group, a common group of soil-borne fungi due to the resemblance of its ascospores and cleistothecia to those of Emericella nidulans. Aspergillus unguis is distinctive, however, in possessing spicular hyphae. A number of synonyms have been collapsed into this species, including Sterigmatocystis unguis, Aspergillus laokiashanensis and Aspergillus mellinus.

Aspergillus creber is a species of fungus in the genus Aspergillus. It is from the Versicolores section. The species was first described in 2012.

<i>Aspergillus clavatus</i> Species of fungus

Aspergillus clavatus is a species of fungus in the genus Aspergillus with conidia dimensions 3–4.5 x 2.5–4.5 μm. It is found in soil and animal manure. The fungus was first described scientifically in 1834 by the French mycologist John Baptiste Henri Joseph Desmazières.

Penicillium commune is an indoor fungus belonging to the genus Penicillium. It is known as one of the most common fungi spoilage moulds on cheese. It also grows on and spoils other foods such as meat products and fat-containing products like nuts and margarine. Cyclopiazonic acid and regulovasine A and B are the most important mycotoxins produced by P. commune. The fungus is the only known species to be able to produce both penitrem A and roquefortine. Although this species does not produce penicillin, it has shown to have anti-pathogenic activity. There are no known plant, animal or human diseases caused by P. commune.

<i>Aspergillus parasiticus</i> Species of fungus

Aspergillus parasiticus is a fungus belonging to the genus Aspergillus. This species is an unspecialized saprophytic mold, mostly found outdoors in areas of rich soil with decaying plant material as well as in dry grain storage facilities. Often confused with the closely related species, A. flavus, A. parasiticus has defined morphological and molecular differences. Aspergillus parasiticus is one of three fungi able to produce the mycotoxin, aflatoxin, one of the most carcinogenic naturally occurring substances. Environmental stress can upregulate aflatoxin production by the fungus, which can occur when the fungus is growing on plants that become damaged due to exposure to poor weather conditions, during drought, by insects, or by birds. In humans, exposure to A. parasiticus toxins can cause delayed development in children and produce serious liver diseases and/or hepatic carcinoma in adults. The fungus can also cause the infection known as aspergillosis in humans and other animals. A. parasiticus is of agricultural importance due to its ability to cause disease in corn, peanut, and cottonseed.

Aspergillus sclerotiorum is a species of fungus in the genus Aspergillus. It is from the Circumdati section. The species was first described in 1933. A. sclerotiorum has been reported to produce penicillic acid, xanthomegnin, viomellein, and vioxanthin.

<i>Penicillium spinulosum</i> Species of fungus

Penicillium spinulosum is a non-branched, fast-growing fungus with a swelling at the terminal of the stipe (vesiculate) in the genus Penicillium. P. spinulosum is able to grow and reproduce in environment with low temperature and low water availability, and is known to be acidotolerant. P. spinulosum is ubiquitously distributed, and can often be isolated from soil. Each individual strain of P. spinulosum differs from others in their colony morphology, including colony texture, amount of sporulation and roughness of conidia and conidiophores.

Aspergillus wentii is an asexual, filamentous, endosymbiotic fungus belonging to the mold genus, Aspergillus. It is a common soil fungus with a cosmopolitan distribution, although it is primarily found in subtropical regions. Found on a variety of organic materials, A. wentii is known to colonize corn, cereals, moist grains, peanuts and other ground nut crops. It is also used in the manufacture of biodiesel from lipids and is known for its ability to produce enzymes used in the food industry.

Cladosporium herbarum is a common fungus found worldwide in organic and inorganic matter. It is efficiently distributed in the air, where it exists as the most frequently occurring fungal species. It can grow over a wide range of temperatures including very cold environments, giving it the ability to grow on refrigerated meat and form "black spots". Its high prevalence in the air and production of allergens makes C. herbarum an important exacerbant of asthma and hay fever.

Aspergillus viridinutans is a species of fungus in the genus Aspergillus. The species was first isolated in Frankston, Victoria, Australia and described in 1954. It is from the Fumigati section of Aspergillus. Several fungi from this section produce heat-resistant ascospores, and the isolates from this section are frequently obtained from locations where natural fires have previously occurred. A. viridinutans has been identified as the cause of chronic aspergillosis. The mycotoxin viriditoxin was first identified in A. viridinutans. A draft genome sequence of the strain derived from the original species description has been generated.

Aspergillus carneus is a fast-growing, filamentous fungus found on detritus and in fertile soil worldwide. It is characterized by its yellow, thick-walled hyphae and biseriate sterigmata. The fungus produces citrinin and 5 unique depsipeptides, Aspergillicins A-E.

References

  1. 1 2 Krijgsheld, P.; Bleichrodt, R.; van Veluw, G. J.; Wang, F.; Muller, W. H.; Dijksterhuis, J.; Wosten, H. A. B. (14 September 2012). "Development in Aspergillus". Studies in Mycology. 74 (1): 1–29. doi:10.3114/sim0006. PMC   3563288 . PMID   23450714.
  2. 1 2 Machida, edited by Masayuki; Gomi, Katsuya (2010). Aspergillus : molecular biology and genomics. Wymondham, Norfolk, UK: Caister Academic. p. 23. ISBN   978-1-904455-53-0.{{cite book}}: |first= has generic name (help)
  3. 1 2 3 Bossche, edited by Hugo Vanden; Mackenzie, Donald W.R.; Cauwenbergh, Geert (1988). Aspergillus and aspergillosis. New York: Plenum Press. p. 37. ISBN   978-0-306-42828-9.{{cite book}}: |first= has generic name (help)
  4. ↑ Gock, Melissa A; Hocking, Ailsa D; Pitt, John I; Poulos, Peter G (1 February 2003). "Influence of temperature, water activity and pH on growth of some xerophilic fungi". International Journal of Food Microbiology. 81 (1): 11–19. doi:10.1016/S0168-1605(02)00166-6. PMID   12423914.
  5. ↑ Stevenson, A., Hamill, P. G., O'kane, C. J., Kminek, G., Rummel, J. D., Voytek, M. A., Dijksterhuis, J., and Hallsworth, J. E. "Aspergillus penicillioides differentiation and cell division at 0.585 water activity." Environmental Microbiology 19.2 (2017):687-697.
  6. 1 2 3 4 5 6 7 Samson, edited by Robert A.; Pitt, John I. (1990). Modern concepts in pencillium and aspergillus classification. New York: Plenum Press. pp. 249–256. ISBN   978-0-306-43516-4.{{cite book}}: |first= has generic name (help)
  7. 1 2 3 4 5 6 Samson, ed. by Robert A.; Pitt, John I. (2000). Integration of modern taxonomic methods for Penicillium and Aspergillus classification. Amsterdam: Harwood Acad. Publ. p. 369. ISBN   978-90-5823-159-8.{{cite book}}: |first= has generic name (help)
  8. 1 2 3 4 5 6 7 8 9 10 11 Raper, K.B.; Fennell, D.I. (1965). The genus aspergillus. Baltimore: The Williams & Wilkins company. p. 232.
  9. 1 2 3 C, Thom; Church M. The Aspergilli. Baltimore, Maryland: Williams & Wilkins. pp. 28, 75, 126.
  10. ↑ T, Miki; Hiroko,K; Junta,S (1999). "Identity of the xerophilic species Aspergillus penicillioides: Integrated analysis of the genotypic and phenotypic characters". J. Gen. Appl. Microbiol. 45 (1): 29–37. doi: 10.2323/jgam.45.29 . PMID   12501399.
  11. 1 2 "Home - Aspergillus penicilloides CBS 540.65 v1.0".
  12. 1 2 Van Asselt, L. (1 July 1999). "Review : Interactions between domestic mites and fungi". Indoor and Built Environment. 8 (4): 216–220. doi:10.1177/1420326X9900800402. S2CID   208622997.
  13. ↑ Berenbaum, May (1990). Ninety-nine gnats, nits, and nibblers. Illustrations by John Parker. Urbana: University of Illinois Press. pp.  40. ISBN   978-0-252-06027-4.
  14. 1 2 3 Petrova-Nikitina, A. D.; Antropova, A. B.; Bilanenko, E. N.; Mokeeva, V. L.; Chekunova, L. N.; Bulgakova, T. A.; Zheltikova, T. M. (17 June 2011). "Population dynamics of mites of the family pyroglyphidae and micromycetes in laboratory cultures". Entomological Review. 91 (3): 377–387. doi:10.1134/S0013873811030134. S2CID   1197288.
  15. 1 2 3 HAY, D. B.; Hart, B. J.; Douglas, A. E. (July 1993). "Effects of the fungus Aspergillus penicillioides on the house dust mite Dermatophagoides pteronyssinus: an experimental re-evaluation". Medical and Veterinary Entomology. 7 (3): 271–274. doi:10.1111/j.1365-2915.1993.tb00687.x. PMID   8369562. S2CID   30863502.
  16. ↑ Walter, Henry (1988). Chap. 17 in Paper Conservation Catalog. American Institute for Conservation Book and Paper Group. pp. 2–10.
  17. ↑ Koestler, Robert J., ed. (2003). Art, biology, and conservation: biodeterioration of works of art. New York, NY: Metropolitan Museum of Art. p. 285. ISBN   978-1-58839-107-0.
  18. ↑ Walter, Henry (1992). Paper Conservation Catalog (PDF). American Institute for Conservation Book and Paper Group. pp. 1–3.
  19. ↑ Hamilos, D. L. (12 May 2010). "Allergic fungal rhinitis and rhinosinusitis". Proceedings of the American Thoracic Society. 7 (3): 245–252. doi:10.1513/pats.200909-098AL. PMID   20463255.
  20. ↑ Centraalbureau voor Schimmelcultures. "Aspergillus penicillioides". Strain Database. CBS, Utrecht: The Netherlands.
  21. ↑ Haleem Khan, A.A.; Mohan Karuppayil, S. (1 October 2012). "Fungal pollution of indoor environments and its management". Saudi Journal of Biological Sciences. 19 (4): 405–426. doi:10.1016/j.sjbs.2012.06.002. PMC   3730554 . PMID   23961203.
  22. ↑ Gandhi, Vivek D.; Davidson, Courtney; Asaduzzaman, Muhammad; Nahirney, Drew; Vliagoftis, Harissios (13 April 2013). "House Dust Mite Interactions with Airway Epithelium: Role in Allergic Airway Inflammation". Current Allergy and Asthma Reports. 13 (3): 262–270. doi:10.1007/s11882-013-0349-9. PMID   23585216. S2CID   12708851.
  23. ↑ "Sick Building Syndrome". Doctor Fungus. Archived from the original on 23 November 2013. Retrieved 17 October 2013.
  24. 1 2 3 4 Abe, K. (1 June 2012). "Assessment of home environments with a fungal index using hydrophilic and xerophilic fungi as biologic sensors". Indoor Air. 22 (3): 173–185. doi:10.1111/j.1600-0668.2011.00752.x. PMID   21995759. S2CID   23287801.
  25. 1 2 3 Seo, Janghoo; Kato, Shinsuke; Tatsuma, Tetsu; Chino, Satoko; Takada, Kazutake; Notsu, Hideo (1 July 2008). "Biosensing of an indoor volatile organic compound on the basis of fungal growth". Chemosphere. 72 (9): 1286–1291. Bibcode:2008Chmsp..72.1286S. doi:10.1016/j.chemosphere.2008.04.063. PMID   18555511.
  26. ↑ Seppanen O; Kurnitski J (2009). In: WHO Guidelines for Indoor Air Quality: Dampness and Mould. World Health Organization. Retrieved 30 October 2013.
  27. 1 2 3 Smith, edited by John E.; Pateman, John A. (1977). Genetics and physiology of Aspergillus. London: Academic Press. pp. 466–467. ISBN   978-0-12-650960-1.{{cite book}}: |first= has generic name (help)
  28. 1 2 3 Lugauskas, A; Raila, A; Railiene, M; Raudoniene, V (2006). "Toxic micromycetes in grain raw material during its processing". Annals of Agricultural and Environmental Medicine. 13 (1): 147–61. PMID   16841886.
  29. 1 2 al.], edited by S. Roussos ... [et (1997). Advances in solid state fermentation : proceedings of the 2nd International Symposium on Solid State Fermentation, FMS-95, Montpellier, France. Dordrecht: Kluwer Academic Publishers. pp. 39–47. ISBN   978-0-7923-4732-3.{{cite book}}: |first= has generic name (help)
  30. 1 2 3 4 Vroumsia, T; Steiman, R; Seiglemurandi, F; Benoitguyod, J (September 2005). "Fungal bioconversion of 2,4-dichlorophenoxyacetic acid (2,4-D) and 2,4-dichlorophenol (2,4-DCP)". Chemosphere. 60 (10): 1471–1480. Bibcode:2005Chmsp..60.1471V. doi:10.1016/j.chemosphere.2004.11.102. PMID   16201028.
  31. 1 2 Isshiki, Kengo; Asai, Yasuyuki; Tanaka, Sumiko; Nishio, Maki; Uchida, Tomofumi; Okuda, Toru; Komatsubara, Saburo; Sakurai, Naoki (1 January 2001). "Aurantiamide Acetate, a Selective Cathepsin Inhibitor, Produced by Aspergillus penicillioides". Bioscience, Biotechnology, and Biochemistry. 65 (5): 1195–1197. doi: 10.1271/bbb.65.1195 . PMID   11440138. S2CID   32945904.
  32. 1 2 F, Ihuhua. "Fungal treatment of petrochemical effluent by an Aspergillus penicillioides (Spegazzini) species using the cross-flow micro-screen and pH-auxostat concept" (PDF). eWISA. Archived from the original (PDF) on 3 December 2013. Retrieved 14 November 2013.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.