Bartonella

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Bartonella
Bartonella.jpg
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Bacteria
Kingdom: Pseudomonadati
Phylum: Pseudomonadota
Class: Alphaproteobacteria
Order: Hyphomicrobiales
Family: Bartonellaceae
Gieszczykiewicz 1939 (Approved Lists 1980)
Genus: Bartonella
Strong et al. 1915 (Approved Lists 1980)
Species [1]
Synonyms [1]
  • BartoniaStrong et al. 1913
  • Grahamella(ex Brumpt 1911) Ristic and Kreier 1984
  • Rochalimaea(Macchiavello 1947) Krieg 1961

Bartonella is a genus of Gram-negative bacteria. It is the only genus in the family Bartonellaceae. [2] [3] Facultative intracellular parasites, Bartonella species can infect healthy people, but are considered especially important as opportunistic pathogens. [4] Bartonella species are transmitted by vectors such as fleas, sand flies, and mosquitoes. At least eight Bartonella species or subspecies are known to infect humans. [5]

Contents

Bartonella henselae is the organism responsible for cat scratch disease.

History

Bartonella species have been infecting humans for thousands of years, as demonstrated by Bartonella quintana DNA in a 4000-year-old tooth. [6] The genus is named for Alberto Leonardo Barton Thompson (1871–October 26, 1950), a Peruvian scientist. [7]

Infection cycle

Though some studies have found "no definitive evidence of transmission by a tick to a vertebrate host," [8] [9] Bartonella species are well-known to be transmissible to both animals and humans through various other vectors, such as fleas, lice, and sand flies. [10] [11] Bartonella bacteria are associated with cat-scratch disease, but a study in 2010 concluded, "Clinicians should be aware that ... a history of an animal scratch or bite is not necessary for disease transmission." [12] All current Bartonella species identified in canines are human pathogens. [13]

Pathophysiology

Bartonella infections are remarkable in the wide range of symptoms they can produce. The course of the diseases (acute or chronic) and the underlying pathologies are highly variable. [14]

Bartonella pathophysiology in humans
SpeciesHuman reservoir or
incidental host?		Animal
reservoir		PathophysiologyDistribution
B. bacilliformis ReservoirCauses Carrion's disease (Oroya fever, Verruga peruana) Peru, Ecuador, and Colombia
B. quintana ReservoirJapanese macaqueCauses trench fever, bacillary angiomatosis, and endocarditis Worldwide
B. clarridgeiae IncidentalDomestic cat Cat scratch disease
B. elizabethae IncidentalRat Endocarditis
B. grahamii IncidentalMouseEndocarditis and neuroretinitis
B. henselae IncidentalDomestic catCat scratch disease, bacillary angiomatosis, peliosis hepatis, endocarditis, bacteremia with fever, neuroretinitis, meningitis, encephalitisWorldwide
B. koehlerae IncidentalDomestic cat
B. naantaliensis Reservoir Myotis daubentonii
B. vinsonii IncidentalMouse, dog, domestic cat Endocarditis, bacteremia
B. washoensis IncidentalSquirrel Myocarditis
B. rochalimae IncidentalUnknownCarrion's disease-like symptoms
References: [15] [16] [17] [18] [14]

Treatment

Treatment is dependent on which species or strain of Bartonella is found in a given patient. While Bartonella species are susceptible to a number of standard antibiotics in vitro —macrolides and tetracycline, for example—the efficacy of antibiotic treatment in immunocompetent individuals is uncertain. [14] Immunocompromised patients should be treated with antibiotics because they are particularly susceptible to systemic disease and bacteremia. Drugs of particular effectiveness include trimethoprim-sulfamethoxazole, gentamicin, ciprofloxacin, and rifampin; B. henselae is generally resistant to penicillin, amoxicillin, and nafcillin. [14]

Epidemiology

Homeless intravenous drug users are at high risk for Bartonella infections, particularly B. elizabethae. B. elizabethae seropositivity rates in this population range from 12.5% in Los Angeles, [19] to 33% in Baltimore, Maryland, [20] 46% in New York City, [21] and 39% in Sweden. [22]

Phylogeny

The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN). [1] The phylogeny is based on whole-genome analysis. [23]

References

  1. 1 2 3 4 5 6 7 8 9 "List of Prokaryotic Names with Standing in Nomenclature" . Retrieved 28 March 2015.
  2. ↑ Brenner DJ, O'Connor SP, Winkler HH, Steigerwalt AG (1993). "Proposals To Unify the Genera Bartonella and Rochalimaea, with Descriptions of Bartonella quintana comb. nov., Bartonella vinsonii comb. nov., Bartonella henselae comb. nov., and Bartonella elizabethae comb. nov., and To Remove the Family Bartonellaceae from the Order Rickettsiales". International Journal of Systematic Bacteriology. 43 (4): 777–786. doi: 10.1099/00207713-43-4-777 . ISSN   0020-7713. PMID   8240958.
  3. ↑ Peters D, R. Wigand (1955). "Bartonellaceae". Bacteriol. Rev. 19 (3): 150–159. doi: 10.1128/MMBR.19.3.150-159.1955 . PMC   180822 . PMID   13260099.
  4. ↑ Walker DH (1996). "Rickettsiae". In Baron S, et al. (eds.). Rickettsiae. In: Barron's Medical Microbiology (4th ed.). Univ of Texas Medical Branch. ISBN   978-0-9631172-1-2.
  5. ↑ Chomel BB, Boulouis HJ (2005). "Zoonoses dues aux bactéries du genre Bartonella: nouveaux réservoirs? nouveaux vecteurs?" [Zoonotic diseases caused by bacteria of the genus Bartonella: new reservoirs? new vectors?](PDF). Bull. Acad. Natl. Med. (in French). 189 (3): 465–77, discussion 477–80. PMID   16149211.
  6. ↑ Drancourt M, Tran-Hung L, Courtin J, Lumley H, Raoult D (2005). "Bartonella quintana in a 4000-year-old human tooth". J. Infect. Dis. 191 (4): 607–11. doi: 10.1086/427041 . PMID   15655785.
  7. ↑ "etymologia: Bartonella henselae". Emerging Infectious Diseases. 14 (6): 980. June 2008. doi:10.3201/eid1406.080980. ISSN   1080-6040. PMC   2600307 .
  8. ↑ Angelakis E, Billeter SA, Breitschwerdt EB, Chomel BB, Raoult D (March 2010). "Potential for tick-borne bartonellosis". Emerg Infect Dis. 16 (3): 385–91. doi:10.3201/eid1603.091685. PMC   3322042 . PMID   20202411.
  9. ↑ Telford SR III, Wormser GP (March 2010). "Bartonella spp. transmission by ticks not established". Emerg Infect Dis. 16 (3): 379–84. doi:10.3201/eid1603.090443. PMC   3322007 . PMID   20202410.
  10. ↑ Billeter SA, Levy MG, Chomel BB, Breitschwerdt EB (Mar 2008). "Vector transmission of Bartonella species with emphasis on the potential for tick transmission". Med Vet Entomol. 22 (1): 1–15. doi: 10.1111/j.1365-2915.2008.00713.x . PMID   18380649.
  11. ↑ Vilcins I, Kosoy M, Old JM, Deane EM (2009). Bartonella-like DNA detected in Ixodes ticks (Acari: Ixodida) infesting koalas (Phascolarctos cinereus) in Victoria, Australia. Vector-Borne & Zoonotic Diseases. 9(5), 499-503. DOI: 10.1089/vbz.2008.0132
  12. ↑ Mosbacher M, Elliott SP, Shehab Z, Pinnas JL, Klotz JH, Klotz SA (Sep–Oct 2010). "Cat scratch disease and arthropod vectors: more to it than a scratch?". J Am Board Fam Med. 23 (5): 685–6. doi: 10.3122/jabfm.2010.05.100025 . PMID   20823366.
  13. ↑ Chomel BB, Boulouis HJ, Maruyama S, Breitschwerdt EB (Mar 2006). "Bartonella spp. in pets and effect on human health". Emerg Infect Dis. 12 (3): 389–94. doi:10.3201/eid1203.050931. PMC   3291446 . PMID   16704774.
  14. 1 2 3 4 Rolain JM, Brouqui P, Koehler JE, Maguina C, Dolan MJ, Raoult D (2004). "Recommendations for treatment of human infections caused by Bartonella species". Antimicrob. Agents Chemother. 48 (6): 1921–33. doi:10.1128/AAC.48.6.1921-1933.2004. PMC   415619 . PMID   15155180.
  15. ↑ Zeaiter Z, Liang Z, Raoult D (2002). "Genetic classification and differentiation of Bartonella species based on comparison of partial ftsZ gene sequences". J. Clin. Microbiol. 40 (10): 3641–7. doi:10.1128/JCM.40.10.3641-3647.2002. PMC   130884 . PMID   12354859.
  16. ↑ Jacomo V, Kelly PJ, Raoult D (2002). "Natural history of Bartonella infections (an exception to Koch's postulate)". Clin. Diagn. Lab. Immunol. 9 (1): 8–18. doi:10.1128/CDLI.9.1.8-18.2002. PMC   119901 . PMID   11777823. Archived from the original on 2005-05-26.
  17. ↑ Maco V, Maguiña C, Tirado A, Maco V, Vidal JE (2004). "Carrion's disease (Bartonellosis bacilliformis) confirmed by histopathology in the High Forest of Peru". Rev. Inst. Med. Trop. Sao Paulo. 46 (3): 171–4. doi: 10.1590/S0036-46652004000300010 . PMID   15286824.
  18. ↑ Pulliainen AT, Lilley TM, Vesterinen EJ, Veikkolainen V (2014). "Bats as Reservoir Hosts of Human Bacterial Pathogen, Bartonella mayotimonensis - Volume 20, Number 6—June 2014 - Emerging Infectious Disease journal - CDC". Emerging Infectious Diseases. 20 (6): 960–7. doi:10.3201/eid2006.130956. PMC   4036794 . PMID   24856523.
  19. ↑ Smith HM, Reporter R, Rood MP, et al. (2002). "Prevalence study of antibody to ratborne pathogens and other agents among patients using a free clinic in downtown Los Angeles". J. Infect. Dis. 186 (11): 1673–6. doi: 10.1086/345377 . PMID   12447746.
  20. ↑ Comer JA, Flynn C, Regnery RL, Vlahov D, Childs JE (1996). "Antibodies to Bartonella species in inner-city intravenous drug users in Baltimore, Md". Arch. Intern. Med. 156 (21): 2491–5. doi:10.1001/archinte.156.21.2491. PMID   8944742.
  21. ↑ Comer JA, Diaz T, Vlahov D, Monterroso E, Childs JE (2001). "Evidence of rodent-associated Bartonella and Rickettsia infections among intravenous drug users from Central and East Harlem, New York City". Am. J. Trop. Med. Hyg. 65 (6): 855–60. doi:10.4269/ajtmh.2001.65.855. PMID   11791987. S2CID   22138835.
  22. ↑ McGill S, Hjelm E, Rajs J, Lindquist O, Friman G (2003). "Bartonella spp. antibodies in forensic samples from Swedish heroin addicts". Ann. N. Y. Acad. Sci. 990 (1): 409–13. Bibcode:2003NYASA.990..409M. doi:10.1111/j.1749-6632.2003.tb07402.x. PMID   12860665. S2CID   22712706.
  23. ↑ Hördt A, García López M, Meier-Kolthoff JP, Schleuning M, Weinhold LM, Tindall BJ, Gronow A, Kyrpides NC, Woyke T, Göker M (2020). "Analysis of 1,000+ Type-Strain Genomes Substantially Improves Taxonomic Classification of Alphaproteobacteria". Front. Microbiol. 11: 468. doi: 10.3389/fmicb.2020.00468 . PMC   7179689 . PMID   32373076.
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