Cerebrospinal fluid rhinorrhoea

Last updated
Cerebrospinal fluid rhinorrhoea
Specialty Neurology, neurosurgery, otorhinolaryngology,Oral and maxillofacial surgery
Symptoms clear, colourless liquid draining from nose
Complications infection
Causes basilar skull fracture
Diagnostic method brain scans, testing nasal discharge to see if it is CSF
Differential diagnosis other types of rhinorrhoea
Treatment conservative management: observation neurosurgery: repairing any skull fracture

Cerebrospinal fluid rhinorrhoea (CSF rhinorrhoea) refers to the drainage of cerebrospinal fluid through the nose (rhinorrhoea). It is typically caused by a basilar skull fracture, which presents complications such as infection. It may be diagnosed using brain scans (prompted based on initial symptoms), and by testing to see if discharge from the nose is cerebrospinal fluid. Treatment may be conservative (as many cases resolve spontaneously), but usually involves neurosurgery.

Contents

Classification

CSF rhinorrhoea may be spontaneous, traumatic, or congenital. [1]

Traumatic CSF rhinorrhoea is the most common type of CSF rhinorrhoea. [1] It may be due to severe head injury, or from complications from neurosurgery. [1]

Spontaneous CSF rhinorrhoea is the most common acquired defect in the skull base bones (anterior cranial fossa) causing spontaneous nasal liquorrhea. Defects are often localized in the sphenoid bone and the ethmoid bone. [1]

Congenital CSF rhinorrhoea is the least common type of CSF rhinorrhoea. [1] It may be caused by problems in the embryological development of bones of the skull. [1]

Signs and symptoms

CSF rhinorrhoea involves drainage of cerebrospinal fluid through the nose. [1] This appears as a clear, colourless liquid. [1]

Causes

Traumatic

CSF rhinorrhoea may be a sign of a basilar skull fracture. Other signs of a basilar skull fracture include CSF otorrhoea (drainage of CSF through the ear). [2] It can have devastating complications in some patients, as the communication between the nasal cavity, the cerebrospinal fluid and the central nervous system can result in severe bacterial infections. [3]

CSF rhinorrhoea may be a complication of neurosurgery, such as functional endoscopic sinus surgery, and hypophysectomy (partial or complete removal of the pituitary gland). [1]

Non-traumatic

CSF rhinorrhoea may be caused by the growth of certain cancers (such as pituitary adenoma), congenital problems with bones of the skull, or inflammation that damages the bones of the skull. [1]

Diagnosis

Radiology

If a patient has clear, colourless liquid leaking from the nose, then radiographs or CT scans may be used to look for a basilar skull fracture.

Biochemistry

Measures of CSF components, such as glucose, have been used in the past, but are neither sensitive nor specific. Beta-2 transferrin has a high positive predictive value of CSF rhinorrhoea. [4] It has also been noted to be characterized by unilateral discharge. [3]

Treatment

Surgery

Neurosurgery is usually necessary to prevent the spread of infection to the meninges. [1] [3] Minimally invasive techniques tend to have fewer complications compared to open techniques. [1]

Conservative management

Conservative management includes watchful waiting, as some minor CSF leaks often stop spontaneously.

See also

Related Research Articles

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<span class="mw-page-title-main">Cerebrospinal fluid</span> Clear, colorless bodily fluid found in the brain and spinal cord

Cerebrospinal fluid (CSF) is a clear, colorless body fluid found within the tissue that surrounds the brain and spinal cord of all vertebrates.

<span class="mw-page-title-main">Hydrocephalus</span> Abnormal increase in cerebrospinal fluid in the ventricles of the brain

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<span class="mw-page-title-main">Intracranial pressure</span> Pressure exerted by fluids inside the skull and on the brain

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<span class="mw-page-title-main">Craniotomy</span> Surgical operation on skull

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Rhinorrhea, rhinorrhoea, or informally runny nose is the free discharge of a thin mucus fluid from the nose; it is a common condition. It is a common symptom of allergies or certain viral infections, such as the common cold or COVID-19. It can be a side effect of crying, exposure to cold temperatures, cocaine abuse, or drug withdrawal, such as from methadone or other opioids. Treatment for rhinorrhea may be aimed at reducing symptoms or treating underlying causes. Rhinorrhea usually resolves without intervention, but may require treatment by a doctor if symptoms last more than 10 days or if symptoms are the result of foreign bodies in the nose.

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Cisternography is a medical imaging technique to examine the flow of cerebrospinal fluid (CSF) in the brain, and spinal cord. The gold standard for diagnosis of a cranial cerebrospinal fluid leak is CT cisternography. For the diagnosis of a spinal CSF leak radionuclide cisternography also known as radioisotope cisternography is used. The false negative rate of cisternography is high (30%), so the radiographic study of choice is CT myelography. The third type of cisternography is MR cisternography.

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A cerebrospinal fluid leak is a medical condition where the cerebrospinal fluid (CSF) that surrounds the brain and spinal cord leaks out of one or more holes or tears in the dura mater. A CSF leak is classed as either spontaneous (primary), having no known cause, or nonspontaneous (secondary) where it is attributed to an underlying condition. Causes of a primary CSF leak are those of trauma including from an accident or intentional injury, or arising from a medical intervention known as iatrogenic. A basilar skull fracture as a cause can give the sign of CSF leakage from the ear nose or mouth. A lumbar puncture can give the symptom of a post-dural-puncture headache.

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References

  1. 1 2 3 4 5 6 7 8 9 10 11 12 Banks, Caroline A.; Palmer, James N.; Chiu, Alexander G.; O'Malley, Bert W.; Woodworth, Bradford A.; Kennedy, David W. (2009-06-01). "Endoscopic closure of CSF rhinorrhea: 193 cases over 21 years". Otolaryngology–Head and Neck Surgery. 140 (6): 826–833. doi:10.1016/j.otohns.2008.12.060. ISSN   0194-5998.
  2. "CSF Otorrhea: Practice Essentials, Epidemiology, Etiology". 28 November 2023. Retrieved 13 January 2024.
  3. 1 2 3 CSF Rhinorrhea at eMedicine
  4. Kerr, Julie T.; Chu, Felix W.K.; Bayles, Stephen W. (2005). "Cerebrospinal Fluid Rhinorrhea: Diagnosis and Management". Otolaryngologic Clinics of North America. 38 (4): 597–611. doi:10.1016/j.otc.2005.03.011. PMID   16005720.