Christian B. Anfinsen
Christian B. Anfinsen in 1969
Christian Boehmer Anfinsen Jr.
March 26, 1916
|Died||May 14, 1995 79) (aged|
|Alma mater|| Swarthmore College (BA, 1937)|
University of Pennsylvania (MS, 1939)
Harvard Medical School (PhD, 1943)
|Known for||Ribonuclease, Anfinsen's dogma|
|Spouse(s)||Florence Kenenger (1941-1978; divorced; 3 children)|
Libby Shulman Ely (m. 1979; 4 stepchildren)
|Awards||Nobel Prize in Chemistry (1972)|
Christian Boehmer Anfinsen Jr. (March 26, 1916 – May 14, 1995)was an American biochemist. He shared the 1972 Nobel Prize in Chemistry with Stanford Moore and William Howard Stein for work on ribonuclease, especially concerning the connection between the amino acid sequence and the biologically active conformation (see Anfinsen's dogma).
Anfinsen was born in Monessen, Pennsylvania, into a family of Norwegian American immigrants. His parents were Sophie (née Rasmussen) and Christian Boehmer Anfinsen Sr., a mechanical engineer.The family moved to Philadelphia in the 1920s. He earned a bachelor's degree from Swarthmore College in 1937. While attending Swarthmore College he played varsity football and joined the Delta Upsilon fraternity.
In 1939, he earned a master's degree in organic chemistry from the University of Pennsylvania. In 1939, The American-Scandinavian Foundation awarded Anfinsen a fellowship to develop new methods for analyzing the chemical structure of complex proteins, namely enzymes, at the Carlsberg Laboratory in Copenhagen, Denmark. In 1941, Anfinsen was offered a university fellowship for doctoral study in the Department of Biological Chemistry at Harvard Medical School. There, Anfinsen received his Ph.D. in biochemistry in 1943.In 1979, he converted to Judaism, by undergoing an Orthodox conversion and that same year he quit smoking. Although Anfinsen wrote in 1985 that his feelings on religion still reflect a fifty-year period of orthodox agnosticism.
Anfinsen had three children with his first wife, Florence Kenenger, to whom he was married from 1941 to 1978. He married Libby Shulman Ely, with whom he had 4 stepchildren, in 1979.
His papers were donated to the National Library of Medicine by Libby Anfinsen between 1998 and 1999.
In 1950, the National Heart Institute, part of the National Institutes of Health in Bethesda, Maryland, recruited Anfinsen as chief of its laboratory of cell physiology. In 1954, a Rockefeller Foundation fellowship enabled Anfinsen to return to the Carlsberg Laboratory for a year and a Guggenheim Foundation fellowship allowed him to study at the Weizmann Institute of Science in Rehovot, Israel from 1958 to 1959.He was elected a Fellow of the American Academy of Arts and Sciences in 1958.
In 1962, Anfinsen returned to Harvard Medical School as a visiting professor and was invited to become chair of the department of chemistry. He was subsequently appointed chief of the laboratory of chemical biology at the National Institute of Arthritis and Metabolic Diseases (now the National Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases), where he remained until 1981. In 1981, Anfinsen became a founding member of the World Cultural Council.From 1982 until his death in 1995, Anfinsen was professor of biophysical chemistry at Johns Hopkins.
Anfinsen published more than 200 original articles, mostly in the area of the relationships between structure and function in proteins. He was also a pioneer of ideas in the area of nucleic acid compaction. In 1961, he showed that ribonuclease could be refolded after denaturation while preserving enzyme activity, thereby suggesting that all the information required by protein to adopt its final conformation is encoded in its amino-acid sequence. He belonged to the National Academy of Sciences (USA), the Royal Danish Academy of Sciences and Letters and the American Philosophical Society.
Established in 1996, The Christian B. Anfinsen Award is presented annually to distinguished scientists, the Awards recognize excellence and outstanding achievements in the multidisciplinary fields of protein science, and honor distinguished contributions in the areas of leadership, education, or service. It is sponsored by The Protein Society, and recognizes significant technical achievements in the field of protein science.
Past recipients of the Christian B. Anfinsen Award include:
William Howard Stein was an American biochemist.
Stanford Moore was an American biochemist. He shared a Nobel Prize in Chemistry in 1972 (with Christian B. Anfinsen and William Howard Stein, for work done at Rockefeller University on the structure of the enzyme ribonuclease and for contributing to the understanding of the connection between the chemical structure and catalytic activity of the ribonuclease molecule.
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Anfinsen's dogma is a postulate in molecular biology that states that, at least for a small globular protein in its standard physiological environment, the native structure is determined only by the protein's amino acid sequence. The dogma was championed by the Nobel Prize Laureate Christian B. Anfinsen from his research on the folding of ribonuclease A. The postulate amounts to saying that, at the environmental conditions at which folding occurs, the native structure is a unique, stable and kinetically accessible minimum of the free energy. The three conditions:
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Martha Vaughan was an American biochemist at the National Heart Lung and Blood Institute (NHLBI), part of the National Institutes of Health (NIH) in Bethesda, Maryland. She holds the title of emeritus scientist in the Laboratory of Metabolic Regulation and previously served as chief of NHLBI’s Laboratory of Cellular Metabolism. At the NIH, much of her work has focused on cell signaling, cellular regulation, lipid metabolism, and the identification of key proteins associated with cholera toxin and pertussis toxin. Vaughan first came to the NIH in the agency’s fledgling National Heart Institute, now NHLBI, and with the title of senior assistant surgeon worked on protein synthesis in the Building 3 laboratory of biochemist and public scientist Christian B. Anfinsen, Ph.D., who went on to share the 1972 Nobel Prize in Chemistry
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