Cytosol nonspecific dipeptidase

CNDP2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4RUH
Identifiers
Aliases	CNDP2 , CN2, CPGL, HEL-S-13, HsT2298, PEPA, CNDP dipeptidase 2 (metallopeptidase M20 family), carnosine dipeptidase 2
External IDs	OMIM: 169800; MGI: 1913304; HomoloGene: 10085; GeneCards: CNDP2; OMA:CNDP2 - orthologs
Gene location (Human) Chr. Chromosome 18 (human) [1] Band 18q22.3 Start 74,495,816 bp [1] End 74,523,454 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 E4 Start 84,685,590 bp [2] End 84,703,827 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in kidney tubule renal medulla endothelial cell human kidney mucosa of ileum glomerulus metanephric glomerulus amniotic fluid jejunal mucosa corpus callosum Top expressed in vestibular membrane of cochlear duct right kidney proximal tubule Paneth cell vestibular sensory epithelium stroma of bone marrow jejunum human kidney internal carotid artery ileum More reference expression data BioGPS n/a
Gene ontology Molecular function carboxypeptidase activity peptidase activity hydrolase activity metallopeptidase activity dipeptidase activity metal ion binding alanylglutamate dipeptidase activity Cellular component extracellular exosome nucleoplasm cytoplasm cytosol Biological process metabolism glutathione biosynthetic process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55748 66054 Ensembl ENSG00000133313 ENSMUSG00000024644 UniProt Q96KP4 Q9D1A2 RefSeq (mRNA) NM_001168499 NM_018235 NM_001370248 NM_001370249 NM_001370250 NM_001370254 NM_001289531 NM_023149 RefSeq (protein) NP_001161971 NP_060705 NP_001357177 NP_001357178 NP_001357179 NP_001357183 NP_001276460 NP_075638 Location (UCSC) Chr 18: 74.5 – 74.52 Mb Chr 18: 84.69 – 84.7 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Cytosol nonspecific dipeptidase
Identifiers
EC no.	3.4.13.18
CAS no.	9025-31-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Cytosolic non-specific dipeptidase (EC 3.4.13.18) also known as carnosine dipeptidase 2 is an enzyme that in humans is encoded by the CNDP2 gene. ^{[5] [6] [7]} This enzyme catalyses the hydrolysis of dipeptides, preferentially those containing hydrophobic amino acids. The human enzyme uses manganese ions as a cofactor. ^[8] In addition to its function as a peptidase, the enzyme also functions to generate N-lactoyl amino acids, such as N-lactoyl-phenylalanine, via the process of "reverse proteolysis". ^[9] A similar pathway conjugates amino acids to Beta-hydroxybutyric acid. ^[10]

See also

• N-lactoyl-phenylalanine, a chemical compound produced by this enzyme

References

1. GRCh38: Ensembl release 89: ENSG00000133313 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024644 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Teufel M, Saudek V, Ledig JP, Bernhardt A, Boularand S, Carreau A, et al. (February 2003). "Sequence identification and characterization of human carnosinase and a closely related non-specific dipeptidase". The Journal of Biological Chemistry. 278 (8): 6521–6531. doi: 10.1074/jbc.M209764200 . PMID   12473676.
6. "Entrez Gene: CNDP2 carnosine dipeptidase 2".
7. Bauer K (1998). "Cytosol non-specific dipeptidase". In Barrett AJ, Rawlings ND, Woessner JF (eds.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 1520–1522.
8. "UniProt: CDNP2 - Cytosolic non-specific dipeptidase: Homo sapiens".
9. Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, et al. (May 11, 2015). "N-lactoyl-amino acids are ubiquitous metabolites that originate from CDNP2-mediated reverse proteolysis of lactate and amino acids". Proceedings of the National Academy of Sciences of the USA. 112 (21): 6601–6606. Bibcode:2015PNAS..112.6601J. doi: 10.1073/pnas.1424638112 . PMC   4450436 . PMID   25964343.
10. Moya-Garzon MD, Wang M, Li VL, Lyu X, Wei W, Tung AS, et al. (2024). "A β-hydroxybutyrate shunt pathway generates anti-obesity ketone metabolites". Cell. 188 (1): 175–186.e20. doi: 10.1016/j.cell.2024.10.032 . PMC  11724754. PMID   39536746.

External links

• Cytosol+non-specific+dipeptidase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)