Perilymph

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Perilymph
Cochlea-crosssection.svg
Cross-section of cochlea. Perilymph is located in the scala vestibuli and scala tympani - the aqua regions at the top and bottom of the diagram.
Gray927.png
Cross-section of semi-circular canal and duct showing perilymphatic space
Details
Identifiers
Latin perilympha
MeSH D010498
TA98 A15.3.03.056
TA2 6938
FMA 60908
Anatomical terminology

Perilymph is an extracellular fluid located within the inner ear. It is found within the scala tympani and scala vestibuli of the cochlea. The ionic composition of perilymph is comparable to that of plasma and cerebrospinal fluid. The major cation in perilymph is sodium, with the values of sodium and potassium concentration in the perilymph being 138  mM and 6.9  mM, respectively. [1] It is also named Cotunnius' liquid and liquor cotunnii for Domenico Cotugno.

Contents

Structure

The inner ear has two major parts, the cochlea and the vestibular organ. They are connected in a series of canals in the temporal bone referred to as the bony labyrinth. The bone canals are separated by the membranes in parallel spaces referred to as the membranous labyrinth. The membranous labyrinth contains endolymph, and is surrounded by perilymph. [2] The perilymph in the bony labyrinth serves as connection to the cerebrospinal fluid of the subarachnoid space via the perilymphatic duct. [3]

Composition

Perilymph and endolymph have unique ionic compositions suited to their functions in regulating electrochemical impulses of hair cells necessary for hearing. The electric potential of endolymph is ~80-90 mV more positive than perilymph due to a higher concentration of potassium cations (K+) in endolymph and higher sodium (Na+) in perilymph. [4] This is referred to as the endocochlear potential. [5]

Perilymph is the fluid contained within the bony labyrinth, surrounding and protecting the membranous labyrinth; perilymph resembles extracellular fluid in composition (sodium salts are the predominant positive electrolyte) and, via the cochlear aqueduct (sometimes referred to as the "perilymphatic duct"), is in continuity with cerebrospinal fluid.

Endolymph is the fluid contained within the scala media of the membranous labyrinth of the inner ear and within the semicircular canals of the vestibular apparatus; endolymph resembles intracellular fluid in composition (potassium is the main cation).

Apart from the importance in the electric cochlear potential, the perilymph also contains a large number of proteins, e.g. extracellular enzymes and immunoglobulins. These proteins are important for the immune response and metabolism among others physiological functions. [6]

Clinical significance

It has also been suggested that perilymph and endolymph participate in a unidirectional flow that is interrupted in Ménière's disease.

Related Research Articles

Inner ear Innermost part of the vertebrate ear

The inner ear is the innermost part of the vertebrate ear. In vertebrates, the inner ear is mainly responsible for sound detection and balance. In mammals, it consists of the bony labyrinth, a hollow cavity in the temporal bone of the skull with a system of passages comprising two main functional parts:

Cochlea Snail-shaped part of inner ear involved in hearing

The cochlea is the part of the inner ear involved in hearing. It is a spiral-shaped cavity in the bony labyrinth, in humans making 2.75 turns around its axis, the modiolus. A core component of the cochlea is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating the fluid chambers in the coiled tapered tube of the cochlea.

Cochlear, the adjective form of cochlea, may refer to:

Semicircular canals Organ located in innermost part of ear

The semicircular canals or semicircular ducts are three semicircular, interconnected tubes located in the innermost part of each ear, the inner ear. The three canals are the horizontal, superior and posterior semicircular canals.

Basilar membrane

The basilar membrane is a stiff structural element within the cochlea of the inner ear which separates two liquid-filled tubes that run along the coil of the cochlea, the scala media and the scala tympani. The basilar membrane moves up and down in response to incoming sound waves, which are converted to traveling waves on the basilar membrane.

Organ of Corti Receptor organ for hearing

The organ of Corti, or spiral organ, is the receptor organ for hearing and is located in the mammalian cochlea. This highly varied strip of epithelial cells allows for transduction of auditory signals into nerve impulses' action potential. Transduction occurs through vibrations of structures in the inner ear causing displacement of cochlear fluid and movement of hair cells at the organ of Corti to produce electrochemical signals.

Auditory system Sensory system used for hearing

The auditory system is the sensory system for the sense of hearing. It includes both the sensory organs and the auditory parts of the sensory system.

Ear Organ of hearing and balance

The ear is the organ that enables hearing and, in mammals, body balance using the vestibular system. In mammals, the ear is usually described as having three parts—the outer ear, the middle ear and the inner ear. The outer ear consists of the pinna and the ear canal. Since the outer ear is the only visible portion of the ear in most animals, the word "ear" often refers to the external part alone. The middle ear includes the tympanic cavity and the three ossicles. The inner ear sits in the bony labyrinth, and contains structures which are key to several senses: the semicircular canals, which enable balance and eye tracking when moving; the utricle and saccule, which enable balance when stationary; and the cochlea, which enables hearing. The ears of vertebrates are placed somewhat symmetrically on either side of the head, an arrangement that aids sound localisation.

Endolymph

Endolymph is the fluid contained in the membranous labyrinth of the inner ear. The major cation in endolymph is potassium, with the values of sodium and potassium concentration in the endolymph being 0.91 mM and 154 mM, respectively. It is also called Scarpa's fluid, after Antonio Scarpa.

Stereocilia (inner ear)

In the inner ear, stereocilia are the mechanosensing organelles of hair cells, which respond to fluid motion in numerous types of animals for various functions, including hearing and balance. They are about 10–50 micrometers in length and share some similar features of microvilli. The hair cells turn the fluid pressure and other mechanical stimuli into electric stimuli via the many microvilli that make up stereocilia rods. Stereocilia exist in the auditory and vestibular systems.

Tympanic duct

The tympanic duct or scala tympani is one of the perilymph-filled cavities in the inner ear of humans. It is separated from the cochlear duct by the basilar membrane, and it extends from the round window to the helicotrema, where it continues as vestibular duct.

Cochlear duct Cavity in the cochlea of the inner ear

The cochlear duct is an endolymph filled cavity inside the cochlea, located between the tympanic duct and the vestibular duct, separated by the basilar membrane and the vestibular membrane respectively. The cochlear duct houses the organ of Corti.

Vestibular membrane Membrane in the cochlea in the inner ear

The vestibular membrane, vestibular wall or Reissner's membrane, is a membrane inside the cochlea of the inner ear. It separates the cochlear duct from the vestibular duct. It helps to transmit vibrations from fluid in the vestibular duct to the cochlear duct. Together with the basilar membrane, it creates a compartment in the cochlea filled with endolymph, which is important for the function of the spiral organ of Corti. It allows nutrients to travel from the perilymph to the endolymph of the membranous labyrinth. It may be damaged in Ménière's disease. It is named after the German anatomist Ernst Reissner.

Membranous labyrinth System of tubes and chambers in the inner ear of humans

The membranous labyrinth is a collection of fluid filled tubes and chambers which contain the receptors for the senses of equilibrium and hearing. It is lodged within the bony labyrinth in the inner ear and has the same general form; it is, however, considerably smaller and is partly separated from the bony walls by a quantity of fluid, the perilymph.

Crista ampullaris

The crista ampullaris is the sensory organ of rotation. They are found in the ampullae of each of the semicircular canals of the inner ear, meaning that there are 3 pairs in total. The function of the crista ampullaris is to sense angular acceleration and deceleration.

In the anatomy of the human ear, the perilymphatic duct is where the perilymphatic space is connected to the subarachnoid space. This works as a type of shunt to eliminate excess perilymph fluid from the perilymphatic space around the cochlea of the ear.

The neural encoding of sound is the representation of auditory sensation and perception in the nervous system.

The endocochlear potential is the positive voltage of 80-100mV seen in the cochlear endolymphatic spaces. Within the cochlea the EP varies in the magnitude all along its length. When a sound is presented, the endocochlear potential changes either positive or negative in the endolymph, depending on the stimulus. The change in the potential is called the summating potential.

Dark cells are specialized nonsensory epithelial cells found on either side of the vestibular organs, and lining the endolymphatic space. These dark-cell areas in the vestibular organ are structures involved in the production of endolymph, an inner ear fluid, secreting potassium towards the endolymphatic fluid. Dark cells take part in fluid homeostasis to preserve the unique high-potassium and low-sodium content of the endolymph and also maintain the calcium homeostasis of the inner ear.

Vestibular duct

The vestibular duct or scala vestibuli is a perilymph-filled cavity inside the cochlea of the inner ear that conducts sound vibrations to the cochlear duct.

References

  1. Bosher SK, Warren RL (1968-11-05). "Observations on the electrochemistry of the cochlear endolymph of the rat: a quantitative study of its electrical potential and ionic composition as determined by means of flame spectrophotometry". Proceedings of the Royal Society B . 171 (1023): 227–247. Bibcode:1968RSPSB.171..227B. doi:10.1098/rspb.1968.0066. PMID   4386844. S2CID   32638469.
  2. "Membranous Labyrinth - an overview". Science Direct . Retrieved 2021-03-17.
  3. Blumenfeld, Hal (2010). Neuroanatomy through Clinical Cases second edition. Sinauer Associates, Inc.
  4. Konishi T, Hamrick PE, Walsh PJ (1978). "Ion transport in guinea pig cochlea. I. Potassium and sodium transport". Acta Otolaryngol . 86 (1–2): 22–34. doi:10.3109/00016487809124717. PMID   696294.
  5. Wangemann, Philine (2006-10-01). "Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential". The Journal of Physiology. 576 (Pt 1): 11–21. doi:10.1113/jphysiol.2006.112888. ISSN   0022-3751. PMC   1995626 . PMID   16857713.
  6. Edvardsson Rasmussen, Jesper; Laurell, Göran; Rask-Andersen, Helge; Bergquist, Jonas; Eriksson, Per Olof (2018). "The proteome of perilymph in patients with vestibular schwannoma. A possibility to identify biomarkers for tumor associated hearing loss?". PLOS ONE. 13 (6): e0198442. Bibcode:2018PLoSO..1398442E. doi: 10.1371/journal.pone.0198442 . ISSN   1932-6203. PMC   5983529 . PMID   29856847.