Pinworm (parasite)

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Pinworm
Evermicularis SC posterior.jpg
Pinworms (U.S.)/Threadworms (U.K.) (Enterobius vermicularis)
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Nematoda
Class: Chromadorea
Order: Rhabditida
Family: Oxyuridae
Genus: Enterobius
Baird, 1853
Species

The pinworm (species Enterobius vermicularis), also known as threadworm (in the United Kingdom, Australia and New Zealand) or seatworm, is a parasitic worm. It is a nematode (roundworm) and a common intestinal parasite or helminth, especially in humans. [7] The medical condition associated with pinworm infestation is known as pinworm infection (enterobiasis) [8] (a type of helminthiasis) or less precisely as oxyuriasis in reference to the family Oxyuridae. [9]

Contents

Other than human, Enterobius vermicularis were reported from bonnet macaque. [10] Other species seen in primates include Enterobius buckleyi in Orangutan [11] and Enterobius anthropopitheci in chimpanzee. Enterobius vermicularis is common in human children and transmitted via the faecal-oral route. Humans are the only natural host of Enterobius vermicularis. [12] Enterobius gregorii, another human species is morphologically indistinguishable from Enterobius vermicularis except the spicule size. [13] Throughout this article, the word "pinworm" refers to Enterobius. In British usage, however, pinworm refers to Strongyloides , while Enterobius is called threadworm. [14]

Classification

The pinworm (genus Enterobius) is a type of roundworm (nematode), and three species of pinworm have been identified with certainty. [15] Humans are hosts only to Enterobius vermicularis (formerly Oxyurias vermicularis). [16] Chimpanzees are host to Enterobius anthropopitheci, which is morphologically distinguishable from the human pinworm. [5] Hugot (1983) claims another species affects humans, Enterobius gregorii, which is supposedly a sister species of E. vermicularis, and has a slightly smaller spicule (i.e., sexual organ). [17] Its existence is controversial, however; Totkova et al. (2003) consider the evidence to be insufficient, [6] and Hasegawa et al. (2006) contend that E. gregorii is a younger stage of E. vermicularis. [4] [5] Regardless of its status as a distinct species, E. gregorii is considered clinically identical to E. vermicularis. [16]

Morphology

Two female pinworms next to a ruler: The markings are 1 mm apart. Threadworm.jpg
Two female pinworms next to a ruler: The markings are 1 mm apart.

The adult female has a sharply pointed posterior end, is 8 to 13 mm long, and 0.5 mm thick. [18] The adult male is considerably smaller, measuring 2 to 5 mm long and 0.2 mm thick, and has a curved posterior end. [18] The eggs are translucent [18] and have a surface that adheres to objects. [19] The eggs measure 50 to 60 μm by 20 to 30 μm, and have a thick shell flattened on one side. [18] The small size and colourlessness of the eggs make them invisible to the naked eye, except in barely visible clumps of thousands of eggs. Eggs may contain a developing embryo or a fully developed pinworm larva. [18] The larvae grow to 140–150 μm in length. [19]

Life cycle

Life cycle of E. vermicularis showing the stages inside and outside of the human body Enterobius vermicularis life cycle.tif
Life cycle of E. vermicularis showing the stages inside and outside of the human body

The entire life cycle, from egg to adult, takes place in the human gastrointestinal tract of a single host, [18] [19] from about 2–4 weeks [20] or about 4–8 weeks. [21] E. vermicularis molts four times; the first two within the egg before hatching and two before becoming an adult worm. [22]

Although infection often occurs via ingestion of embryonated eggs by inadequate hand washing or nail biting, inhalation followed by swallowing of airborne eggs may occur rarely. [19] [21] The eggs hatch in the duodenum (i.e., first part of the small intestine). [23] The emerging pinworm larvae grow rapidly to a size of 140 to 150 μm, [20] and migrate through the small intestine towards the colon. [19] During this migration, they moult twice and become adults. [19] [21] Females survive for 5 to 13 weeks, and males about 7 weeks. [19] The male and female pinworms mate in the ileum (i.e., last part of the small intestine), [19] whereafter the male pinworms usually die, [23] and are passed out with stool. [24] The gravid female pinworms settle in the ileum, caecum (i.e., beginning of the large intestine), appendix and ascending colon, [19] where they attach themselves to the mucosa [21] and ingest colonic contents. [25]

Almost the entire body of a gravid female becomes filled with eggs. [23] The estimations of the number of eggs in a gravid female pinworm range from about 11,000 [19] to 16,000. [21] The egg-laying process begins about five weeks after initial ingestion of pinworm eggs by the human host. [19] The gravid female pinworms migrate through the colon towards the rectum at a rate of 12 to 14 cm per hour. [19] They emerge from the anus, and while moving on the skin near the anus, the female pinworms deposit eggs either through (1) contracting and expelling the eggs, (2) dying and then disintegrating, or (3) bodily rupture due to the host scratching the worm. [23] After depositing the eggs, the female becomes opaque and dies. [24] The female emerges from the anus to obtain the oxygen necessary for the maturation of the eggs. [24]

Infection

E. vermicularis causes the medical condition pinworm infection also known as enterobiasis, whose primary symptom is itching in the anal area. [26] Extraintestinal disease is rare and most commonly involves the female reproductive tract, [27] but spleen abscess has also been reported. [28] Enterobius vermicularis infections are found to be correlated with stunting and lower mean I.Q. among prepubescent children. [29] [30]

Distribution

The pinworm has a worldwide distribution, [25] and is the cause of the most common helminthiasis (parasitic worm infection) in the United States, western Europe, and Oceania. [21] In the United States, a study by the Center of Disease Control reported an overall incidence rate of 11.4% among children. [21] Pinworms are particularly common in children, with prevalence rates in this age group having been reported as high as 61% in India, 50% in England, 39% in Thailand, 37% in Sweden, and 29% in Denmark. [21] Finger sucking has been shown to increase both incidence and relapse rates, [21] and nail biting has been similarly associated. [31] Because it spreads from host to host through contamination, pinworms are common among people living in close contact, and tends to occur in all people within a household. [25] The prevalence of pinworms is not associated with gender, [25] nor with any particular social class, race, or culture. [21] Pinworms are an exception to the tenet that intestinal parasites are uncommon in affluent communities. [21]

A fossilized nematode egg was detected in 240 million-year-old fossil dung, [32] showing that parasitic pinworms already infested pre-mammalian cynodonts. The earliest known instance of the pinworms associated with humans is evidenced by pinworm eggs found in human coprolites carbon dated to 7837 BC found in western Utah. [19]

See also

Notes

  1. 1 2 Hasegawa et al. 2005.
  2. 1 2 3 4 5 6 "Enterobius". NCBI taxonomy. Bethesda, MD: National Center for Biotechnology Information. Retrieved 28 February 2019.
  3. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 Registry-Migration.Gbif.Org (2022). "GBIF Backbone Taxonomy". GBIF Secretariat. doi:10.15468/39omei.
  4. 1 2 Hasegawa et al. 1998
  5. 1 2 3 Hasegawa et al. 2006
  6. 1 2 Totkova et al. 2003
  7. ↑ Encyclopædia Britannica.
  8. ↑ Merriam-Webster: Enterobiasis
  9. ↑ Merriam-Webster: Oxyuriasis
  10. ↑ C.P., Arjun (October 2015). "A Study of Gastrointestinal Parasites in Bonnet Macaques (Macaca radiata) of Pookode, Wayanad, Kerala". Zoos' Print Journal. Zoo Outreach Organization. Retrieved 20 October 2015.
  11. ↑ Foitová, Ivona; Civáňová, Kristína; Baruš, Vlastimil; Nurcahyo, Wisnu (1 July 2014). "Phylogenetic relationships between pinworms (Nematoda: Enterobiinae) parasitising the critically endangered orang-utan, according to the characterisation of molecular genomic and mitochondrial markers". Parasitology Research. 113 (7): 2455–2466. doi:10.1007/s00436-014-3892-y. ISSN   1432-1955. PMID   24880237. S2CID   15076891.
  12. ↑ Panidis, Stavros; Paramythiotis, Daniel; Panagiotou, Dimitris; Batsis, Georgios; Salonikidis, Spyridon; Kaloutsi, Vassiliki; Michalopoulos, Antonios (1 January 2011). "Acute appendicitis secondary to Enterobius vermicularis infection in a middle-aged man: a case report". Journal of Medical Case Reports. 5: 559. doi: 10.1186/1752-1947-5-559 . ISSN   1752-1947. PMC   3245485 . PMID   22128765.
  13. ↑ CP, Arjun (October 2015). "A Study of Gastrointestinal Parasites in Bonnet Macaque ( Macaca radiata) of Pookode, Wayanad, Kerala" (PDF). Zoos' Print Journal. 10.
  14. ↑ Vanderkooi 2000, p. B-152 & B-225
  15. ↑ NCBI taxonomy database 2009
  16. 1 2 dpdx 2009
  17. ↑ Hugot 1983
  18. 1 2 3 4 5 6 Gutiérrez 2005, p. 354.
  19. 1 2 3 4 5 6 7 8 9 10 11 12 13 Cook 1994, p. 1159
  20. 1 2 Cook et al. 2009, p. 1516
  21. 1 2 3 4 5 6 7 8 9 10 11 Burkhart & burkhart 2005, p. 837
  22. ↑ Rett, Doug. "Enterobius vermicularis". Animal Diversity Web. Retrieved 4 January 2021.
  23. 1 2 3 4 Garcia 1999, p. 246
  24. 1 2 3 Caldwell 1982, p. 307.
  25. 1 2 3 4 Gutiérrez 2005, p. 355.
  26. ↑ "Enterobiasis leads to itching" . Retrieved 20 August 2011.
  27. ↑ Graves, B.; Leder, K.; Sinickas, V.; Sheorey, H. (February 2018). "Extraintestinal Enterobius vermicularis". Pathology. 50: S113–S114. doi:10.1016/j.pathol.2017.12.322.
  28. ↑ Agostinis, Paolo; Cappello, Dario; Riccardi, Niccolò; Michelutti, Teresa; Orsaria, Maria; Zerbato, Verena; Di Bella, Stefano (11 September 2023). Amoroso, Anthony; Nori, Priya; Riedel, David J (eds.). "A 25-Year-Old Woman With Long-Lasting Abdominal Pain and Spleen Abscess". Clinical Infectious Diseases. 77 (5): 795–798. doi:10.1093/cid/ciad047. ISSN   1058-4838. PMID   37696671.
  29. ↑ Guan, M.; Han, B. (2019). "Association between intestinal worm infection and malnutrition among rural children aged 9–11 years old in Guizhou Province, China". BMC Public Health. 19 (1): 1204. doi: 10.1186/s12889-019-7538-y . PMC   6719348 . PMID   31477069.
  30. ↑ Bahader, S. M.; Ali, G. S.; Shaalan, A. H.; Khalil, H. M.; Khalil, N. M. (1995). ""Effects of Enterobius vermicularis infection on intelligence quotient (I.Q) and anthropometric measurements of Egyptian rural children"". Journal of the Egyptian Society of Parasitology. 25 (1): 183–194. PMID   7602161.
  31. ↑ Cook 1994, p. 1160
  32. ↑ Mitrica, Dragos (2 December 2014). "Scientists find 240 million-year-old parasite that infected mammals' ancestor". ZME Science. Retrieved 14 February 2023.

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References

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