Interstate 35 (I-35) is a major Interstate Highway in the central United States. As with most primary Interstates that end in a five, it is a major cross-country, north–south route. It stretches from Laredo, Texas, near the Mexican border to Duluth, Minnesota, at Minnesota State Highway 61 and 26th Avenue East. The highway splits into I-35E and I-35W in two separate places, the Dallas–Fort Worth metroplex in Texas and at the Minnesota twin cities of Minneapolis–Saint Paul.
Interstate 44 (I-44) is an Interstate Highway in the central United States. Although it is nominally an east–west road as it is even-numbered, it follows a more southwest–northeast alignment. Its western terminus is in Wichita Falls, Texas, at a concurrency with U.S. Route 277 (US 277), US 281, and US 287; its eastern terminus is at I-70 in St. Louis, Missouri. I-44 is one of five Interstates built to bypass US 66; this highway covers the section between Oklahoma City and St. Louis. Virtually the entire length of I-44 east of Springfield, Missouri, was once US 66, which was upgraded from two to four lanes from 1949 to 1955. The section of I-44 west of Springfield was built farther south than US 66 in order to connect Missouri's section with the already completed Will Rogers Turnpike, which Oklahoma wished to carry their part of I-44.
U.S. Route 81 or U.S. Highway 81 (US 81) is a major north–south U.S. highway that extends for 1,220 miles (1,960 km) in the central United States and is one of the original United States Numbered Highways established in 1926 by the American Association of State Highway Officials.
U.S. Route 67 is a major north–south U.S. highway which extends for 1,560 miles (2,511 km) in the Central United States. The southern terminus of the route is at the United States-Mexico border in Presidio, Texas, where it continues south as Mexican Federal Highway 16 upon crossing the Rio Grande. The northern terminus is at U.S. Route 52 in Sabula, Iowa. US 67 crosses the Mississippi River twice along its routing. The first crossing is at West Alton, Missouri, where US 67 uses the Clark Bridge to reach Alton, Illinois. About 240 miles (390 km) to the north, US 67 crosses the river again at the Rock Island Centennial Bridge between Rock Island, Illinois, and Davenport, Iowa. Additionally, the route crosses the Missouri River via the Lewis Bridge a few miles southwest of the Clark Bridge.
U.S. Route 287 (US 287) is a north–south United States highway. At 1,791 miles (2,882 km) long, it is the second longest three-digit U.S. Route, behind US 281. It serves as the major truck route between Dallas-Fort Worth and Amarillo, Texas, and between Fort Collins, Colorado, and Laramie, Wyoming. The highway is broken into two segments by Yellowstone National Park, where unnumbered park roads serve as a connector.
U.S. Route 84 (US 84) is an east–west United States Numbered Highway that started as a short Georgia–Alabama route in the original 1926 scheme. Later, in 1941, it had been extended all the way to Colorado. The highway's eastern terminus is a short distance east of Midway, Georgia, at an Interchange with I-95. The road continues toward the nearby Atlantic Ocean as a county road. Its northern terminus is in Pagosa Springs, Colorado, at an intersection with US 160.
U.S. Route 82 is an east–west United States highway in the Southern United States. Created on July 1, 1931 across central Mississippi and southern Arkansas, US 82 eventually became a 1,625-mile-long (2,615 km) route extending from the White Sands of New Mexico to Georgia's Atlantic coast.
U.S. Route 83 (US 83) is a major north–south United States Numbered Highway that extends 1,885 miles (3,034 km) in the central United States. Only four other north–south routes are longer: US 1, US 41, US 59, and US 87, while US 83 follows a straighter north-south path than all of these. Nearly half of its mileage is in the state of Texas. The highway's northern terminus is north of Westhope, North Dakota, at the Canadian border, where it continues as Manitoba Highway 83 (PTH 83). The southern terminus is at the Veterans International Bridge in Brownsville, Texas. Together, US 83 and PTH 83 form a continuously numbered north-south highway with a combined distance of 3,450 kilometres (2,140 mi).
U.S. Route 183 (US 183) is a north–south United States highway. The highway's northern terminus is in Presho, South Dakota, at an intersection with Interstate 90. Its southern terminus is in Refugio, Texas, at the southern intersection of U.S. Highway 77 and Alternate US 77.
U.S. Route 62 or U.S. Highway 62 (US 62) is an east–west United States Highway in the southern and northeastern United States. It runs from the Mexican border at El Paso, Texas, to Niagara Falls, New York, near the Canadian border. It is the only east–west United States Numbered Highway that connects Mexico and Canada. Parts of US 62 follow what once was the Ozark Trail, including the historic bridge across the South Canadian River in Newcastle, Oklahoma. This bridge was damaged beyond repair by the 2013 Moore tornado that struck Newcastle and Moore, Oklahoma. The highway runs north–south in New York and Pennsylvania.
U.S. Route 54 is an east–west United States Highway that runs northeast–southwest for 1,197 miles (1,926 km) from El Paso, Texas, to Griggsville, Illinois. The Union Pacific Railroad's Tucumcari Line runs parallel to US 54 from El Paso to Pratt, Kansas, which comprises about two-thirds of the route. Truckers refer to this road as "The Bee Line."
U.S. Route 70 or U.S. Highway 70 is an east–west United States highway that runs for 2,381 miles (3,832 km) from eastern North Carolina to east-central Arizona. It is a major east–west highway of the Southeastern, Southern and Southwestern United States. Established as one of the original highways of 1926, it originally ran only to Holbrook, Arizona, then was extended in 1934 as a coast to coast route, with the current eastern terminus near the Atlantic Ocean in Atlantic, North Carolina, and the former western terminus near the Pacific Ocean in Los Angeles, California. The current western terminus was then truncated to US 60 / SR 77 in Globe, Arizona. Before the completion of the Interstate system, U.S. Highway 70 was sometimes referred to as the "Broadway of America", due to its status as one of the main east–west thoroughfares in the nation. It was also promoted as the "Treasure Trail" by the U.S. Highway 70 Association as of 1951.
U.S. Highway 87 is a north–south United States highway that runs for 1,998 miles (3,215 km) from northern Montana to southern Texas, making it the longest north-south road to not have a "1" in its number and the third longest north-south road in the country, behind U.S. 41 and U.S. 1. Most of the portion from Billings, Montana to Raton, New Mexico is co-signed along Interstates 90 and 25. It is also co-signed along the majority of I-27 in Texas and future plans call for the interstate to be extended along the US 87 corridor. As of 2004, the highway's northern terminus is in Havre, Montana, at US 2 and its southern terminus is in Port Lavaca, Texas, at SH 238.
U.S. Route 277 is a north–south United States Highway that is a spur route of U.S. Route 77. It no longer connects to its parent route, US 77, although it does intersect another one of its spur. It runs for 633 miles (1,019 km) across Oklahoma and Texas. US 277's northern terminus is in Newcastle, Oklahoma at Interstate 44, which is also the northern terminus of the H.E. Bailey Turnpike. Its southern terminus is in Carrizo Springs, Texas at U.S. Route 83. It passes through the states of Oklahoma and Texas.
State Highway 8, also abbreviated as SH-8 or OK-8, is a highway maintained by the U.S. state of Oklahoma. Because it runs mainly north–south, it has an even number. Highway 8 runs from U.S. Highway 277 in Cyril, Oklahoma to the state line south of Kiowa, Kansas, for a total length of 179.1 miles (288.2 km) The highway has two lettered spur routes.
North Dakota Highway 3 (ND 3) is a 247.530-mile-long (398.361 km) major north–south state highway in North Dakota, United States, that spans the entire state. It travels from South Dakota Highway 45 (SD 45) at the South Dakota state line, south of Ashley north to Manitoba Highway 10 (PTH 10) at the International Peace Garden on the Canada–United States border.
U.S. Highway 59 (US 59) in the U.S. state of Texas is named the Lloyd Bentsen Highway, after Lloyd Bentsen, former U.S. senator from Texas. In northern Houston, US 59, co-signed with Interstate 69 (I-69), is the Eastex Freeway. To the south, which is also co-signed with I-69, it is the Southwest Freeway. The stretch of the Southwest Freeway just west of The Loop was formerly one of the busiest freeways in North America, with a peak AADT of 371,000 in 1998.
U.S. Route 281 (US 281) is a United States Numbered Highway that runs from the Mexican border in the Rio Grande Valley to the Canadian border near Dunseith, North Dakota. In the state of Texas, the highway is a major south–north corridor, connecting Brownsville to the Oklahoma state line at the Red River in Burkburnett. Several segments of U.S. 281 are concurrent with Interstate routes, including I-69C in the Rio Grande Valley, I-37 in San Antonio, and I-44 north of Wichita Falls.
U.S. Route 70 is a transcontinental U.S. highway extending from Globe, Arizona to Atlantic, North Carolina. Along the way, 289.81 miles (466.40 km) of its route passes through the state of Oklahoma. Entering the state south of Davidson, the highway serves Oklahoma's southern tier before exiting the state east of Broken Bow. It serves the cities of Ardmore, Durant, Hugo, and Idabel, as well as Tillman, Cotton, Jefferson, Carter, Marshall, Bryan, Choctaw, and McCurtain counties.
U.S. Route 281 (US-281) is a part of the U.S. Highway System that runs from near the Mexican border north to the International Peace Garden, north of Dunseith, North Dakota, at the Canadian border, where it continues as Highway 10. In the state of Kansas, US-281 is a main north–south highway that runs from the Oklahoma border north to the Nebraska border. US-281 passes within one mile (1.6 km) to the east of the Geographic center of the contiguous United States, which its connected to via K-191 (K-191).
ND 3 / PTH 10 at the U.S.–Canada border near Dunseith, ND 
