U.S. Route 75 is a north–south U.S. Highway that runs 1,239 miles (1,994 km) in the central United States. The highway's northern terminus is located at the Canadian border near Noyes, Minnesota, at a now-closed border crossing. From this point, the highway once continued farther north as Manitoba Highway 75. Its southern terminus is located at Interstate 30 (I-30) and I-45 in Dallas, Texas, where US 75 is known as North Central Expressway.
U.S. Route 69 (US 69) is a major north–south United States highway in the central United States. When it was first created, it was only 150 miles (241 km) long, but it has since been expanded into a Minnesota to Texas cross-country route. The highway's southern terminus is in Port Arthur, Texas at an intersection with State Highway 87. Its northern terminus is in Albert Lea, Minnesota at Minnesota State Highway 13.
U.S. Route 266 is a 43.09-mile (69.35 km), east–west U.S. Numbered Highway in Okmulgee, McIntosh, and Muskogee counties in Oklahoma, United States, that connects U.S. Route 62 U.S. Route 75 in Henryetta with U.S. Route 64 in Warner. The highway no longer meets the former route of its parent, U.S. Route 66, and is closely paralleled by Interstate 40 (I-40), which replaced US 266 as the major east–west highway east of Oklahoma City during the 1960s.
State Highway 66 is a 192.7-mile (310.1 km) state highway in the U.S. state of Oklahoma, beginning at U.S. Highway 81 in El Reno and ending at U.S. Highway 60 near White Oak. The highway was designated in 1985 as a replacement for the decommissioned U.S. Highway 66. Although most of the highway follows Historic Route 66, the highway follows US 66's final alignment, joining Interstate 44 through Tulsa and Oklahoma City, while older versions of the route follow various city streets through both cities.
State Highway 9, abbreviated as SH-9, OK-9, or simply Highway 9, is a major east–west highway in the U.S. state of Oklahoma. Spanning across the central part of the state, SH-9 begins at the Texas state line west of Vinson, Oklahoma, and ends at the Arkansas state line near Fort Smith, Arkansas. State Highway 9 is a major highway around the Norman area. At 348.1 miles (560.2 km), SH-9 is Oklahoma's second-longest state highway.
State Highway 7 is a 150.5-mile (242.2 km) highway in southern Oklahoma. This lengthy highway connects many towns in Oklahoma's "Little Dixie" area. It runs from Interstate 44 in Lawton to U.S. 69/US-75 in Atoka.
State Highway 51, abbreviated to SH-51 or OK-51, is a major state highway in Oklahoma, United States. It runs for 332.8 miles (535.6 km) east–west across the state, running from the Texas state line to Arkansas. It is the third-longest state highway in the system.
The Indian Nation Turnpike, also designated State Highway 375 (SH-375), is a controlled-access toll road in southeastern Oklahoma, United States, running between Hugo and Henryetta, a distance of 105.2 miles (169.3 km). It is the longest tollway in the state.
State Highway 165 (SH-165) is a state highway in Muskogee County, Oklahoma. It runs east along Peak Boulevard in the southern part of Muskogee from US-64 to the northern terminus of the southern section of the Muskogee Turnpike, then runs north as a freeway connecting the two sections of the turnpike. The total length of the highway is 8.21 miles (13.21 km).
State Highway 31 is a state highway in Oklahoma. It runs 132.6 miles in an irregular west-to-east pattern in the southeastern part of the state.
State Highway 43 is a state highway in Oklahoma, United States. It runs 65.3 miles west-to-east through Coal, Atoka, Pushmataha and Pittsburg counties.
U.S. Highway 77 (US-77) in Oklahoma is a 267.21-mile-long (430.03 km) U.S. Highway in the U.S. state of Oklahoma. It travels from south to north, paralleling Interstate 35 (I-35), connecting Texas to Kansas through the central part of the state. It travels through many major cities, including Ardmore, Oklahoma City and its suburbs, Guthrie, and Ponca City. It has four lettered spur routes.
Interstate 40 (I-40) is an Interstate Highway in Oklahoma that runs 331 miles (533 km) across the state from Texas to Arkansas. West of Oklahoma City, it parallels and replaces old U.S. Highway 66 (US-66), and, east of Oklahoma City, it parallels US-62, US-266, and US-64. I-40 is the longest Interstate highway in Oklahoma.
In Oklahoma, U.S. Highway 62 (US 62) runs diagonally across the state, from the Texas state line in far southwestern Oklahoma to the Arkansas state line near Fayetteville. US-62 spends a total of 402.48 miles (647.73 km) in the Sooner State. The highway passes through fifteen of Oklahoma's counties. Along the way the route serves two of Oklahoma's largest cities, Lawton and Oklahoma City, as well as many regionally important cities, like Altus, Chickasha, Muskogee, and Tahlequah. Despite this, US-62 has no lettered spur routes like many other U.S. routes in Oklahoma do.
U.S. Highway 59 (US-59) heads along the eastern portion of the state of Oklahoma. US-59's 216.47-mile (348.37 km) route through Oklahoma takes it through the mountainous terrain of the eastern Oklahoma Ouachitas and Ozarks. US-59 serves several lakes and towns through Oklahoma's Green Country, including Grand Lake, a major recreation center. The route enters the state from Arkansas near Fogel, Arkansas, and ends at the Kansas state line south of Chetopa, Kansas.
U.S. Route 70 is a transcontinental U.S. highway extending from Globe, Arizona to Atlantic, North Carolina. Along the way, 289.81 miles (466.40 km) of its route passes through the state of Oklahoma. Entering the state south of Davidson, the highway serves Oklahoma's southern tier before exiting the state east of Broken Bow. It serves the cities of Ardmore, Durant, Hugo, and Idabel, as well as Tillman, Cotton, Jefferson, Carter, Marshall, Bryan, Choctaw, and McCurtain counties.
U.S. Route 60 (US-60) is a transcontinental U.S. highway extending from near Brenda, Arizona to Virginia Beach, Virginia on the Atlantic Ocean. Along the way, 352.39 miles (567.12 km) of the route lies within the state of Oklahoma. The highway crosses into the state from Texas west of Arnett and serves many towns and cities in the northern part of the state, including Arnett, Seiling, Fairview, Enid, Ponca City, Pawhuska, Bartlesville, and Vinita. US-60 exits Oklahoma near Seneca, Missouri. In Oklahoma, US-60 has three business routes, serving Tonkawa, Ponca City, and Seneca. The first 60.2 miles (96.9 km) of the route, from the Texas line to Seiling, is also designated as State Highway 51 (SH-51).
U.S. Route 412 is a U.S. highway in the south-central portion of the United States, connecting Springer, New Mexico to Columbia, Tennessee. A 504.11-mile (811.29 km) section of the highway crosses the state of Oklahoma, traversing the state from west to east. Entering the state southwest of Boise City, US-412 runs the length of the Oklahoma Panhandle and serves the northern portion of the state's main body, before leaving the state at West Siloam Springs. Along the way, the route serves many notable cities and towns, including Boise City, Guymon, Woodward, Enid, and the state's second-largest city, Tulsa.
U.S. Route 75 is a major north–south highway that enters the U.S. state of Oklahoma from Texas concurrent with US 69 crossing the Red River. US 75 serves the city of Tulsa, the 2nd largest city in Oklahoma.
U.S. Route 64 (US-64) is a U.S. highway running from the Four Corners area to the Outer Banks of North Carolina. Between these two points, the highway passes through the entire width of Oklahoma; a total of 591.17 miles (951.40 km) of US-64 lies in the state of Oklahoma. US-64 enters the state from New Mexico, crossing the line between the two states between Clayton, New Mexico, and Boise City in Cimarron County. The route runs the full length of the Oklahoma Panhandle, then serves the northernmost tier of counties in the main body of the state before dipping southeastward to Tulsa, the state's second-largest city. From Tulsa, the highway continues southeast, leaving Oklahoma just west of Fort Smith, Arkansas. In addition to Tulsa, US-64 serves fifteen Oklahoma counties and the cities of Guymon, Woodward, Enid, and Muskogee.
US 69 / US 75 south of Colbert 
US 70 in Durant 
US 270 in McAlester 
I-40 in Checotah 
US 266 in Checotah
US 62 / US 64 in Muskogee 
US 412 near Chouteau 
I-44 Toll / Will Rogers Turnpike in Big Cabin 
US 60 in Vinita 
US 59 in Miami 
US-69 / K-7 north of Picher 
