U.S. Route 259 (US 259) is a north–south spur of U.S. Route 59 that runs for 250 miles (400 km) through rural areas of northeastern Texas and southeastern Oklahoma. The highway's southern terminus is near Nacogdoches, Texas, at an interchange with its parent route, US 59. Its northern terminus is in the Ouachita Mountains, approximately 15 miles (24 km) south of Heavener, Oklahoma, where it reunites with US 59. For most of its length, US 259 lies 30–50 miles (48–80 km) to the west of its parent route.
U.S. Route 270 (US 270) is a spur of US 70. It travels for 643 miles (1,035 km) from Liberal, Kansas at US 54 and US 83 to White Hall, Arkansas at Interstate 530 (I-530) and US 65. It travels through the states of Arkansas, Oklahoma, and Kansas. It travels through the cities of Oklahoma City, Oklahoma, Hot Springs, Arkansas, and McAlester, Oklahoma.
U.S. Route 177 (US-177) is a spur of U.S. Route 77. It currently runs for 233 miles (375 km) from South Haven, Kansas at US-81 to Madill, Oklahoma at US-70. It passes through the states of Kansas and Oklahoma.
State Highway 1, sometimes abbreviated as SH-1, is a 209.7-mile (337 km) highway maintained by the U.S. state of Oklahoma. It travels through the southeastern part of the state, nicknamed Little Dixie. SH-1 is signed east and west.
State Highway 9, abbreviated as SH-9, OK-9, or simply Highway 9, is a major east–west highway in the U.S. state of Oklahoma. Spanning across the central part of the state, SH-9 begins at the Texas state line west of Vinson, Oklahoma, and ends at the Arkansas state line near Fort Smith, Arkansas. State Highway 9 is a major highway around the Norman area. At 348.1 miles (560.2 km), SH-9 is Oklahoma's second-longest state highway.
State Highway 7 is a 150.5-mile (242.2 km) highway in southern Oklahoma. This lengthy highway connects many towns in Oklahoma's "Little Dixie" area. It runs from Interstate 44 in Lawton to U.S. 69/US-75 in Atoka.
State Highway 99 (SH-99) is a north–south state highway through central Oklahoma. It runs from the Texas state line at Lake Texoma to the Kansas state line near Lake Hulah. It is 241.5 miles (388.7 km) long. The highway overlaps U.S. Highway 377 (US-377) for over half its length.
State Highway 39, abbreviated as SH-39, is a state highway in the U.S. state of Oklahoma. It is 68.4 miles (110.1 km) in length. It runs east–west through the central part of the state, beginning at unincorporated Tabler, east of Chickasha, and ending east of Konawa. Along the way, SH-39 serves the counties of Grady, McClain, Cleveland, Pottawatomie, and Seminole. It currently has no lettered spurs.
State Highway 51, abbreviated to SH-51 or OK-51, is a major state highway in Oklahoma, United States. It runs for 332.8 miles (535.6 km) east–west across the state, running from the Texas state line to Arkansas. It is the third-longest state highway in the system.
State Highway 14, abbreviated as SH-14, is a highway maintained by the U.S. state of Oklahoma. It is 27.85 miles (44.82 km) long, with its entire route falling in Woods County in the northwestern part of the state. It does not have any lettered spur routes.
State Highway 19, abbreviated as SH-19, is a 171.7-mile-long (276.3 km) highway running through the southern part of the U.S. state of Oklahoma. It is signed east–west.
State Highway 8, also abbreviated as SH-8 or OK-8, is a highway maintained by the U.S. state of Oklahoma. Because it runs mainly north–south, it has an even number. Highway 8 runs from U.S. Highway 277 in Cyril, Oklahoma to the state line south of Kiowa, Kansas, for a total length of 179.1 miles (288.2 km) The highway has two lettered spur routes.
State Highway 59, abbreviated SH-59, is a 93-mile (150 km) state highway in central Oklahoma. It runs from Criner, Oklahoma in McClain Co. to Wewoka.
State Highway 102 is a north–south state highway in central Oklahoma. It runs for 52.9 miles (85.1 km) from Wanette, Oklahoma to Wellston, Oklahoma. It has no lettered spur routes.
State Highway 18, abbreviated as SH-18 or OK-18, is a highway maintained by the U.S. state of Oklahoma. It was once one of the longest state highways in the Oklahoma road system, but now has a total length of 134.4 mi (216.3 km).
State Highway 87 is a highway in southeastern Oklahoma, running for 14.58 miles (23.46 km). It passes through the extreme southeastern corner of the state, running entirely through McCurtain Co. It has no lettered spur routes.
U.S. Route 69 is a major north-south U.S. Highway in the U.S. state of Oklahoma. It extends the corridor formed by U.S. Route 75 in Texas, from Dallas northeast via McAlester and Muskogee to the Will Rogers Turnpike near Vinita. From Vinita to the Kansas state line, US-69 generally parallels the turnpike along old U.S. Highway 66.
U.S. Route 60 (US-60) is a transcontinental U.S. highway extending from near Brenda, Arizona to Virginia Beach, Virginia on the Atlantic Ocean. Along the way, 352.39 miles (567.12 km) of the route lies within the state of Oklahoma. The highway crosses into the state from Texas west of Arnett and serves many towns and cities in the northern part of the state, including Arnett, Seiling, Fairview, Enid, Ponca City, Pawhuska, Bartlesville, and Vinita. US-60 exits Oklahoma near Seneca, Missouri. In Oklahoma, US-60 has three business routes, serving Tonkawa, Ponca City, and Seneca. The first 60.2 miles (96.9 km) of the route, from the Texas line to Seiling, is also designated as State Highway 51 (SH-51).
U.S. Route 412 is a U.S. highway in the south-central portion of the United States, connecting Springer, New Mexico to Columbia, Tennessee. A 504.11-mile (811.29 km) section of the highway crosses the state of Oklahoma, traversing the state from west to east. Entering the state southwest of Boise City, US-412 runs the length of the Oklahoma Panhandle and serves the northern portion of the state's main body, before leaving the state at West Siloam Springs. Along the way, the route serves many notable cities and towns, including Boise City, Guymon, Woodward, Enid, and the state's second-largest city, Tulsa.
U.S. Route 64 (US-64) is a U.S. highway running from the Four Corners area to the Outer Banks of North Carolina. Between these two points, the highway passes through the entire width of Oklahoma; a total of 591.17 miles (951.40 km) of US-64 lies in the state of Oklahoma. US-64 enters the state from New Mexico, crossing the line between the two states between Clayton, New Mexico, and Boise City in Cimarron County. The route runs the full length of the Oklahoma Panhandle, then serves the northernmost tier of counties in the main body of the state before dipping southeastward to Tulsa, the state's second-largest city. From Tulsa, the highway continues southeast, leaving Oklahoma just west of Fort Smith, Arkansas. In addition to Tulsa, US-64 serves fifteen Oklahoma counties and the cities of Guymon, Woodward, Enid, and Muskogee.
US 287 / US 385 Colorado state line (concurrent with US-287/385)
I-344 / Kilpatrick Turnpike near Oklahoma City 
I-44 in Oklahoma City 
I-40 in Oklahoma City 
I-35 in Oklahoma City 
Indian Nation Turnpike in Antlers 
AR 32 at the Arkansas state line
