Vertebrobasilar insufficiency

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Vertebrobasilar insufficiency
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Vertebrobasilar insufficiency (VBI) describes a temporary set of symptoms due to decreased blood flow (ischemia) in the posterior circulation of the brain. The posterior circulation supplies the medulla, pons, midbrain, cerebellum and (in 70-80% of people) supplies the posterior cerebellar artery to the thalamus and occipital cortex. [1] As a result, symptoms vary widely depending which brain region is predominantly affected.

Contents

The term 'vertebrobasilar insufficiency' may be used to describe disease in the vertebral and basilar arteries which predisposes to acute embolic events such as transient ischemic attacks (TIAs) and stroke. [2] Alternatively it may be used to describe recurrent symptoms which result from narrowing (stenosis) of these arteries in combination with changes of blood pressure or head position.

VBI should not be confused with other conditions which may relate to the posterior circulation. 25% of strokes and TIAs affect parts of the brain supplied by the posterior circulation, but many of these are embolic from cardiac or other sources. VBI should also not be confused with beauty parlour syndrome which refers to strokes caused by acute arterial dissection brought on by extreme head positions, such as those maintained during hair washing. [3] [4]

Signs and symptoms

Symptoms relate to impaired brain function in areas supplied by the posterior circulation, as seen in posterior circulation strokes. However, symptoms may be far briefer than those seen in stroke.

Vertigo is a relatively common symptom that can result from ischemia to the cerebellum, medulla or (rarely) the internal auditory artery which supplies the vestibular system of the inner ear. While vertigo is a common feature of VBI or posterior circulation stroke, VBI only rarely presents with vertigo alone (without other neurological signs). [5]

Pathology

VBI results from narrowing of posterior circulation arteries, known as stenosis. The most common cause of arterial stenosis is atherosclerosis, however other pathologies such as fibromuscular dysplasia, dissection, trauma or external compression may occur. [2] Atherosclerotic plaque can rupture, resulting in a source of emboli. These emboli can cause TIAs or strokes in the areas of the brain supplied by the affected artery.

Where stenosis is severe, abrupt changes in blood pressure can temporarily result in inadequate flow through the stenosis, causing symptoms that are usually very brief. [6] A common cause is orthostatic hypotension which results in a fall in blood pressure when the patient changes posture and may be exacerbated by medicines (particularly antihypertensives), dehydration and heat. In reality, orthostatic hypotension can cause vague symptoms (e.g. dizziness) which are similar to those caused by VBI; VBI should only be considered where the stenosis is severe and/or there are focal neurological symptoms specific to the posterior circulation. [6]

VBI may also result from altered blood flow as seen in subclavian steal syndrome.

VBI is described as a cause of symptoms that occur with changes to head position. Rotational vertebral artery syndrome (sometimes referred to as Bow Hunter's Syndrome) results from vertebral artery compression on rotating the neck. [7] The commonest cause is a bone spur from a cervical vertebra, in combination with disease in the opposite vertebral artery. Rotational vertebral artery syndrome is rare.

Diagnosis

The diagnosis of posterior circulation stroke or TIA can be made on the basis of history and physical examination, which should include exclusion of alternative causes for the patient's symptoms and consideration of risk factors for atherosclerosis. To confirm VBI, imaging studies of the posterior circulation can be performed. CT is often the first study performed in acute stroke or TIA, as it is effective at excluding intracranial haemorrhage, however MRI is better at detecting ischemic strokes in the posterior distribution. CT angiography and Magnetic Resonance Angiography (MRA) can be used to detect atherosclerosis and other diseases in the posterior circulation arteries. [8] Both can over-estimate stenosis.

Atherosclerosis is a common finding, and its presence does not confirm that this was the cause of the patient's symptoms.

Alternative diagnoses

VBI is often considered when a patient complains of dizziness. It is important to distinguish dizziness caused by vertigo from the sensation of being light-headed, as the latter is more commonly a result of other conditions.

Brief episodes of vertigo brought on by head movements are more likely to be Benign paroxysmal positional vertigo. Alternatively, carotid sinus hypersensitivity can cause episodes of dizziness and collapse on head turning if the neck brushes against clothing.

Treatment

The main treatment for VBI is to address risk factors for atherosclerosis such as smoking, hypertension and diabetes. Patients are often started on an antiplatelet (e.g. aspirin, clopidogrel) or occasionally an anticoagulant (e.g. warfarin) to reduce the risk of future strokes. Where VBI is causing reproducible symptoms due to stenosis, lifestyle modification to avoid provoking factors (e.g. dehydration, standing rapidly from sitting or lying) may reduce symptoms.

Open surgical repair or stenting can be performed to re-open stenosed vertebral arteries, and intracranial stents have also been successfully used. [9] Further research is required to determine which patients with VBI are likely to benefit.

Related Research Articles

A transient ischemic attack (TIA), commonly known as a mini-stroke, is a temporary (transient) stroke with noticeable symptoms that end within 24 hours. A TIA causes the same symptoms associated with a stroke, such as weakness or numbness on one side of the body, sudden dimming or loss of vision, difficulty speaking or understanding language or slurred speech.

<span class="mw-page-title-main">Interventional radiology</span> Medical subspecialty

Interventional radiology (IR) is a medical specialty that performs various minimally-invasive procedures using medical imaging guidance, such as x-ray fluoroscopy, computed tomography, magnetic resonance imaging, or ultrasound. IR performs both diagnostic and therapeutic procedures through very small incisions or body orifices. Diagnostic IR procedures are those intended to help make a diagnosis or guide further medical treatment, and include image-guided biopsy of a tumor or injection of an imaging contrast agent into a hollow structure, such as a blood vessel or a duct. By contrast, therapeutic IR procedures provide direct treatment—they include catheter-based medicine delivery, medical device placement, and angioplasty of narrowed structures.

<span class="mw-page-title-main">Stroke</span> Death of a region of brain cells due to poor blood flow

Stroke is a medical condition in which poor blood flow to a part of the brain causes cell death. There are two main types of stroke: ischemic, due to lack of blood flow, and hemorrhagic, due to bleeding. Both cause parts of the brain to stop functioning properly.

<span class="mw-page-title-main">Lateral medullary syndrome</span> Medical condition

Lateral medullary syndrome is a neurological disorder causing a range of symptoms due to ischemia in the lateral part of the medulla oblongata in the brainstem. The ischemia is a result of a blockage most commonly in the vertebral artery or the posterior inferior cerebellar artery. Lateral medullary syndrome is also called Wallenberg's syndrome, posterior inferior cerebellar artery (PICA) syndrome and vertebral artery syndrome.

<span class="mw-page-title-main">Amaurosis fugax</span> Medical condition

Amaurosis fugax is a painless temporary loss of vision in one or both eyes.

<span class="mw-page-title-main">Cerebral angiography</span> Angiography that produces images of blood vessels in and around the brain

Cerebral angiography is a form of angiography which provides images of blood vessels in and around the brain, thereby allowing detection of abnormalities such as arteriovenous malformations and aneurysms. It was pioneered in 1927 by the Portuguese neurologist Egas Moniz at the University of Lisbon, who also helped develop thorotrast for use in the procedure.

<span class="mw-page-title-main">Moyamoya disease</span> Disease characterized by constriction of brain arteries

Moyamoya disease is a disease in which certain arteries in the brain are constricted. Blood flow is blocked by constriction and blood clots (thrombosis). A collateral circulation develops around the blocked vessels to compensate for the blockage, but the collateral vessels are small, weak, and prone to bleeding, aneurysm and thrombosis. On conventional angiography, these collateral vessels have the appearance of a "puff of smoke", described as moyamoya (もやもや) in Japanese.

<span class="mw-page-title-main">Vertebral artery</span> Major arteries of the neck

The vertebral arteries are major arteries of the neck. Typically, the vertebral arteries originate from the subclavian arteries. Each vessel courses superiorly along each side of the neck, merging within the skull to form the single, midline basilar artery. As the supplying component of the vertebrobasilar vascular system, the vertebral arteries supply blood to the upper spinal cord, brainstem, cerebellum, and posterior part of brain.

<span class="mw-page-title-main">Carotid artery stenosis</span> Narrowing of the carotid arteries

Carotid artery stenosis is a narrowing or constriction of any part of the carotid arteries, usually caused by atherosclerosis.

<span class="mw-page-title-main">Cerebral infarction</span> Stroke resulting from lack of blood flow

Cerebral infarction, also known as an ischemic stroke, is the pathologic process that results in an area of necrotic tissue in the brain. In mid to high income countries, a stroke is the main reason for disability among people and the 2nd cause of death. It is caused by disrupted blood supply (ischemia) and restricted oxygen supply (hypoxia). This is most commonly due to a thrombotic occlusion, or an embolic occlusion of major vessels which leads to a cerebral infarct. In response to ischemia, the brain degenerates by the process of liquefactive necrosis.

<span class="mw-page-title-main">Watershed stroke</span> Medical condition

A watershed stroke is defined as a brain ischemia that is localized to the vulnerable border zones between the tissues supplied by the anterior, posterior and middle cerebral arteries. The actual blood stream blockage/restriction site can be located far away from the infarcts. Watershed locations are those border-zone regions in the brain supplied by the major cerebral arteries where blood supply is decreased. Watershed strokes are a concern because they comprise approximately 10% of all ischemic stroke cases. The watershed zones themselves are particularly susceptible to infarction from global ischemia as the distal nature of the vasculature predisposes these areas to be most sensitive to profound hypoperfusion.

<span class="mw-page-title-main">Fibromuscular dysplasia</span> Human arterial disease

Fibromuscular dysplasia (FMD) is a non-atherosclerotic, non-inflammatory disease of the blood vessels that causes abnormal growth within the wall of an artery. FMD has been found in nearly every arterial bed in the body, although the most commonly affected are the renal and carotid arteries.

<span class="mw-page-title-main">Subclavian steal syndrome</span> Medical condition

Subclavian steal syndrome (SSS), also called subclavian steal steno-occlusive disease, is a medical condition characterized by retrograde (reversed) blood flow in the vertebral artery or the internal thoracic artery. This reversal occurs due to proximal stenosis (narrowing) or occlusion of the subclavian artery.

<span class="mw-page-title-main">Carotid artery dissection</span> Human disease


Carotid artery dissection is a serious condition in which a tear forms in one of the two main carotid arteries in the neck, allowing blood to enter the artery wall and separate its layers (*dissection*). This separation can lead to the formation of a blood clot, narrowing of the artery, and restricted blood flow to the brain, potentially resulting in stroke. Symptoms vary depending on the extent and location of the dissection and may include a sudden, severe headache, neck or facial pain, vision changes, a drooping eyelid, and stroke-like symptoms such as weakness or numbness on one side of the body, difficulty speaking, or loss of coordination.

<span class="mw-page-title-main">Vertebral artery dissection</span> Tear of the inner lining of the vertebral artery

Vertebral artery dissection (VAD) is a flap-like tear of the inner lining of the vertebral artery, which is located in the neck and supplies blood to the brain. After the tear, blood enters the arterial wall and forms a blood clot, thickening the artery wall and often impeding blood flow. The symptoms of vertebral artery dissection include head and neck pain and intermittent or permanent stroke symptoms such as difficulty speaking, impaired coordination, and visual loss. It is usually diagnosed with a contrast-enhanced CT or MRI scan.

<span class="mw-page-title-main">Cervical artery dissection</span> Medical condition

Cervical artery dissection is dissection of one of the layers that compose the carotid and vertebral artery in the neck (cervix). They include:

Vascular myelopathy refers to an abnormality of the spinal cord in regard to its blood supply. The blood supply is complicated and supplied by two major vessel groups: the posterior spinal arteries and the anterior spinal arteries—of which the Artery of Adamkiewicz is the largest. Both the posterior and anterior spinal arteries run the entire length of the spinal cord and receive anastomotic (conjoined) vessels in many places. The anterior spinal artery has a less efficient supply of blood and is therefore more susceptible to vascular disease. Whilst atherosclerosis of spinal arteries is rare, necrosis in the anterior artery can be caused by disease in vessels originating from the segmental arteries such as atheroma or aortic dissection.

Insufficiency may refer to:

<span class="mw-page-title-main">Arterial embolism</span> Interruption of blood flow to an organ

Arterial embolism is a sudden interruption of blood flow to an organ or body part due to an embolus adhering to the wall of an artery blocking the flow of blood, the major type of embolus being a blood clot (thromboembolism). Sometimes, pulmonary embolism is classified as arterial embolism as well, in the sense that the clot follows the pulmonary artery carrying deoxygenated blood away from the heart. However, pulmonary embolism is generally classified as a form of venous embolism, because the embolus forms in veins. Arterial embolism is the major cause of infarction.

The Vertebral Artery Test or Wallenberg Test is a physical exam for vertebral artery insufficiency.

References

  1. Jones, Jeremy. "Posterior cerebral circulation | Radiology Reference Article". Radiopaedia.org. Retrieved 26 April 2022.
  2. 1 2 Lang, Eddy S. (10 November 2021). "Vertebrobasilar Atherothrombotic Disease" . eMedicine . Archived from the original on 2 February 2023. Retrieved 31 December 2024.
  3. "Warning over 'hair salon stroke'". BBC News . 24 April 2004. Archived from the original on 26 April 2022. Retrieved 26 April 2022.
  4. [ dead link ]
  5. Kerber, K. A.; Brown, D. L.; Lisabeth, L. D.; Smith, M. A.; Morgenstern, L. B. (2006). "Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: A population-based study". Stroke. 37 (10): 2484–7. doi:10.1161/01.STR.0000240329.48263.0d. PMC   1779945 . PMID   16946161.
  6. 1 2 Pirau, L.; Lui, F. (2019). "Vertebrobasilar Insufficiency". StatPearls. StatPearls. PMID   29489229.
  7. "What is Bow Hunter's Syndrome?". Webmd.com.
  8. Abdrabou, Ahmed. "CT angiography of the cerebral arteries (protocol) | Radiology Reference Article". Radiopaedia.org. Retrieved 26 April 2022.
  9. Marks MP, Wojak JC, Al-Ali F, et al. (2006). "Angioplasty for symptomatic intracranial stenosis: clinical outcome". Stroke . 37 (4): 1016–20. doi: 10.1161/01.STR.0000206142.03677.c2 . eISSN   1524-4628. ISSN   0039-2499. LCCN   70019475. OCLC   01714534. PMID   16497979.