B777-81

B777-81
Clinical data
Other names	BRN 6066682
Identifiers
	IUPAC name 4-(1-methyl-4-phenylpiperidin-4-yl)oxyaniline;
CAS Number	78104-11-7 ;
PubChem CID	3060392 ;
ChemSpider	2321322 ;
CompTox Dashboard (EPA)	DTXSID80228740 ;
Chemical and physical data
Formula	C18H22N2O
Molar mass	282.387 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CN1CCC(CC1)(C2=CC=CC=C2)OC3=CC=C(C=C3)N;
	InChI InChI=1S/C18H22N2O/c1-20-13-11-18(12-14-20,15-5-3-2-4-6-15)21-17-9-7-16(19)8-10-17/h2-10H,11-14,19H2,1H3; Key:GNVZOTBLCYEIRW-UHFFFAOYSA-N;

Last updated June 12, 2025

B-777-81 is an antidepressant drug candidate.^[1]

B777-81 works by reversing reserpine and tetrabenazine-induced ptosis in a similar manner to that of imipramine, but with a shorter duration of action. It also antagonizes reserpine-induced hypothermia but it is without effect on the decrease in locomotor activity or catalepsy following reserpine. In vitro, B777-81 inhibited 5-HT uptake in platelets, potentiated the effect of NA^{[ clarification needed ]} on isolated vas deferens and had less anticholinergic effect than imipramine in the isolated ileum.^[2]^[3]

References

↑ Eistetter K, Kley HP, Menge HG, Schaefer H (1983). "B-777-81". Drugs of the Future. 8 (5): 387. doi:10.1358/dof.1983.008.05.65796.
↑ Ankier SI (1986). "4 Recent Progress in the Development of New Antidepressant Drugs". Progress in Medicinal Chemistry. Vol. 23. Elsevier. pp. 121–185. doi:10.1016/S0079-6468(08)70342-4. ISBN 978-0-444-80802-8. PMID 3310107.
↑ Menge HG, Brand U, Kley HP (January 1985). "Classification of New CNS-active Compounds by a Two-lever Drug Discrimination Procedure". Pharmacopsychiatry. 18 (1): 141–142. doi:10.1055/s-2007-1017346.

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[1] Eistetter K, Kley HP, Menge HG, Schaefer H (1983). "B-777-81". Drugs of the Future. 8 (5): 387. doi:10.1358/dof.1983.008.05.65796.

[2] Ankier SI (1986). "4 Recent Progress in the Development of New Antidepressant Drugs". Progress in Medicinal Chemistry. Vol. 23. Elsevier. pp. 121–185. doi:10.1016/S0079-6468(08)70342-4. ISBN 978-0-444-80802-8. PMID 3310107.

[3] Menge HG, Brand U, Kley HP (January 1985). "Classification of New CNS-active Compounds by a Two-lever Drug Discrimination Procedure". Pharmacopsychiatry. 18 (1): 141–142. doi:10.1055/s-2007-1017346.

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