Collagen, type XIV, alpha 1

COL14A1
Identifiers
Aliases	COL14A1 , UND, Collagen, type XIV, alpha 1, collagen type XIV alpha 1, collagen type XIV alpha 1 chain
External IDs	OMIM: 120324; MGI: 1341272; HomoloGene: 18741; GeneCards: COL14A1; OMA:COL14A1 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) [1] Band 8q24.12 Start 120,059,780 bp [1] End 120,373,573 bp [1]
Gene location (Mouse) Chr. Chromosome 15 (mouse) [2] Band 15|15 D1 Start 55,171,146 bp [2] End 55,384,199 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta right coronary artery popliteal artery tibial arteries cartilage tissue ascending aorta gallbladder left coronary artery saphenous vein Achilles tendon Top expressed in efferent ductule vas deferens conjunctival fornix dermis human fetus migratory enteric neural crest cell semi-lunar valve aortic valve vestibular sensory epithelium ascending aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein-macromolecule adaptor activity extracellular matrix structural constituent collagen binding RNA binding extracellular matrix structural constituent conferring tensile strength Cellular component extracellular matrix collagen endoplasmic reticulum lumen extracellular exosome collagen type XIV trimer extracellular space extracellular region collagen-containing extracellular matrix Biological process cell adhesion collagen fibril organization extracellular matrix organization cell-cell adhesion growth plate cartilage chondrocyte morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7373 12818 Ensembl ENSG00000187955 ENSMUSG00000022371 UniProt Q05707 Q80X19 RefSeq (mRNA) NM_021110 NM_001384947 NM_181277 NM_001368422 RefSeq (protein) NP_066933 NP_851794 NP_001355351 Location (UCSC) Chr 8: 120.06 – 120.37 Mb Chr 15: 55.17 – 55.38 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Collagen alpha-1(XIV) chain is a protein that in humans is encoded by the COL14A1 gene. ^{[5] [6] [7]} It likely plays a role in collagen binding and cell-cell adhesion. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000187955 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022371 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Just M, Herbst H, Hummel M, Durkop H, Tripier D, Stein H, Schuppan D (Oct 1991). "Undulin is a novel member of the fibronectin-tenascin family of extracellular matrix glycoproteins". J Biol Chem. 266 (26): 17326–32. doi: 10.1016/S0021-9258(19)47377-8 . PMID   1716629.
6. Bauer M, Dieterich W, Ehnis T, Schuppan D (Jan 1998). "Complete primary structure of human collagen type XIV (undulin)". Biochim Biophys Acta. 1354 (3): 183–8. doi:10.1016/S0167-4781(97)00131-0. PMID   9427527.
7. "Entrez Gene: COL14A1 collagen, type XIV, alpha 1 (undulin)".
8. "COL14A1 - Collagen alpha-1(XIV) chain precursor - Homo sapiens (Human) - COL14A1 gene & protein".

Further reading

• Schuppan D, Cantaluppi MC, Becker J, et al. (1990). "Undulin, an extracellular matrix glycoprotein associated with collagen fibrils". J. Biol. Chem. 265 (15): 8823–32. doi: 10.1016/S0021-9258(19)38962-8 . PMID   2187872.
• Schnittger S, Herbst H, Schuppan D, et al. (1995). "Localization of the undulin gene (UND) to human chromosome band 8q23". Cytogenet. Cell Genet. 68 (3–4): 233–4. doi:10.1159/000133920. PMID   7842743.
• Casini A, Ceni E, Salzano R, et al. (1994). "Regulation of undulin synthesis and gene expression in human fat-storing cells by acetaldehyde and transforming growth factor-beta 1: comparison with fibronectin". Biochem. Biophys. Res. Commun. 199 (2): 1019–26. doi:10.1006/bbrc.1994.1331. PMID   8135774.
• Tono-Oka S, Tanase S, Miike T, Tanaka H (1996). "Transient expression of collagen type XIV during muscle development and its reappearance after denervation and degeneration". J. Histochem. Cytochem. 44 (8): 907–18. doi: 10.1177/44.8.8756762 . PMID   8756762.
• Ehnis T, Dieterich W, Bauer M, et al. (1997). "A chondroitin/dermatan sulfate form of CD44 is a receptor for collagen XIV (undulin)". Exp. Cell Res. 229 (2): 388–97. doi:10.1006/excr.1996.0384. PMID   8986622.
• Göpel C, Schultka R, Schuppan D (1997). "[Age-dependent distribution of collagen and glycoproteins in the blood vessels of the human uterine tube]". Ann. Anat. 179 (1): 83–8. doi:10.1016/S0940-9602(97)80144-6. PMID   9092299.
• Ehnis T, Dieterich W, Bauer M, et al. (1997). "Localization of a binding site for the proteoglycan decorin on collagen XIV (undulin)". J. Biol. Chem. 272 (33): 20414–9. doi: 10.1074/jbc.272.33.20414 . PMID   9252349.
• Imhof M, Trueb B (1999). "Comparative cytogenetic mapping of COL14A1, the gene for human and mouse collagen XIV". Cytogenet. Cell Genet. 84 (3–4): 217–9. doi:10.1159/000015262. PMID   10393435. S2CID   24286993.
• Fukushima M, Hirano S, Tanaka H (2000). "Dorsoventral differential distribution of collagen type XIV around the spinal cord is regulated by the ectoderm". Dev. Growth Differ. 41 (6): 751–8. doi: 10.1046/j.1440-169x.1999.00472.x . PMID   10646805. S2CID   32320869.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerecke DR, Meng X, Liu B, Birk DE (2004). "Complete primary structure and genomic organization of the mouse Col14a1 gene". Matrix Biol. 22 (7): 595–601. doi:10.1016/j.matbio.2003.11.005. PMID   15065570.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Thierry L, Geiser AS, Hansen A, et al. (2005). "Collagen types XII and XIV are present in basement membrane zones during human embryonic development". J. Mol. Histol. 35 (8–9): 803–10. doi:10.1007/s10735-004-1132-y. PMID   15609093. S2CID   30409158.
• Ruehl M, Erben U, Schuppan D, et al. (2006). "The elongated first fibronectin type III domain of collagen XIV is an inducer of quiescence and differentiation in fibroblasts and preadipocytes". J. Biol. Chem. 280 (46): 38537–43. doi: 10.1074/jbc.M502210200 . PMID   16129687.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Nusbaum C, Mikkelsen TS, Zody MC, et al. (2006). "DNA sequence and analysis of human chromosome 8". Nature. 439 (7074): 331–5. Bibcode:2006Natur.439..331N. doi: 10.1038/nature04406 . PMID   16421571.