Dipeptidase 3

DPEP3
Identifiers
Aliases	DPEP3 , MBD3, dipeptidase 3
External IDs	OMIM: 609926 MGI: 1919104 HomoloGene: 23357 GeneCards: DPEP3
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,980,549 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,706,061 bp
RNA expression pattern
	Top expressed in
	sperm; ; blood; ; spleen; ; bone marrow; ; monocyte; ; lymph node; ; duodenum; ; placenta; ; right lung; ; cecum;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; morula; ; secondary oocyte; ; blastocyst; ; ovary; ; blood; ; islet of Langerhans; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase activity ; metalloexopeptidase activity ; dipeptidyl-peptidase activity ; metallopeptidase activity ; hydrolase activity ; metal ion binding ; dipeptidase activity ;
Cellular component	anchored component of membrane ; membrane ; acrosomal vesicle ; plasma membrane ;
Biological process	male meiotic nuclear division ; meiosis ; proteolysis ;
	Sources:Amigo / QuickGO
Orthologs
	64180
	71854
	ENSG00000141096
	ENSMUSG00000031898
	Q9H4B8
	Q9DA79
	NM_022357 ; NM_001129758 ; NM_001370198
	NM_027960
	NP_001123230 ; NP_001357127
	NP_082236
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 29, 2022

Dipeptidase 3 (DPEP3) is a protein that in humans is encoded by the DPEP3 gene.^[5]

This gene encodes a membrane-bound glycoprotein from the family of dipeptidases (EC 3.4.13.19) involved in hydrolytic metabolism of various dipeptides, including penem and carbapenem beta-lactam antibiotics. This gene is located on chromosome 16 in a cluster with another member of this family, DPEP2. Alternatively spliced transcript variants that encode different isoforms have been found for this gene.^[6]

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000141096 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031898 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Habib GM, Shi ZZ, Cuevas AA, Lieberman MW (July 2003). "Identification of two additional members of the membrane-bound dipeptidase family". The FASEB Journal. 17 (10): 1313–5. doi:10.1096/fj.02-0899fje. PMID 12738806. S2CID 15252871.
↑ "Entrez Gene: Dipeptidase 3".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Sabatti C, Service SK, Hartikainen AL, et al. (2009). "Genome-wide association analysis of metabolic traits in a birth cohort from a founder population". Nat. Genet. 41 (1): 35–46. doi:10.1038/ng.271. PMC 2687077 . PMID 19060910.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697 . PMID 12975309.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000141096 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031898 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12738806-5] Habib GM, Shi ZZ, Cuevas AA, Lieberman MW (July 2003). "Identification of two additional members of the membrane-bound dipeptidase family". The FASEB Journal. 17 (10): 1313–5. doi:10.1096/fj.02-0899fje. PMID 12738806. S2CID 15252871.

[entrez-6] "Entrez Gene: Dipeptidase 3".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Dipeptidase 3

Related Research Articles

References

Further reading