Inhibitor of apoptosis domain

Inhibitor of Apoptosis domain
NMR solution structure of the BIR domain of human BIRC2 protein. [1] The protein is rainbow colored cartoon diagram (N-terminus = blue, C-terminus = red) while the coordinated zinc is represented by a grey sphere.
Identifiers
Symbol	BIR
Pfam	PF00653
InterPro	IPR001370
PROSITE	PS50143
SCOP2	1qbh / SCOPe / SUPFAM
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary PDB 1c9q ​, 1e31 ​, 1f3h ​, 1f9x ​, 1g3f ​, 1g73 ​, 1i3o ​, 1jd4 ​, 1jd5 ​, 1jd6 ​, 1m4m ​, 1nw9 ​, 1oxn ​, 1oxq ​, 1oy7 ​, 1q4q ​, 1qbh ​, 1sdz ​, 1se0 ​, 1tfq ​, 1tft ​, 1tw6 ​, 1xb0 ​, 1xb1 ​, 1xox ​, 2i3h ​, 2i3i ​

The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. ^[2] Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins (BIRPs or BIRCs), and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6. ^{[2] [3]}

BIR domains belong to the zinc-finger domain family and characteristically have a number of invariant amino acid residues, including 3 conserved cysteines and one conserved histidine, which coordinate a zinc ion. ^[4] They are typically composed of 4-5 alpha helices and a three-stranded beta sheet.

External links

• Eukaryotic Linear Motif resource motif class LIG_BIR_II_1
• Eukaryotic Linear Motif resource motif class LIG_BIR_III_1
• Eukaryotic Linear Motif resource motif class LIG_BIR_III_2
• Eukaryotic Linear Motif resource motif class LIG_BIR_III_3
• Eukaryotic Linear Motif resource motif class LIG_BIR_III_4

References

1. PDB: 1QBH ​;Hinds MG, Norton RS, Vaux DL, Day CL (July 1999). "Solution structure of a baculoviral inhibitor of apoptosis (IAP) repeat". Nat. Struct. Biol. 6 (7): 648–51. doi:10.1038/10701. PMID   10404221. S2CID   3194182.
2. Silke J, Vaux DL (May 2001). "Two kinds of BIR-containing protein - inhibitors of apoptosis, or required for mitosis". J. Cell Sci. 114 (Pt 10): 1821–7. doi:10.1242/jcs.114.10.1821. PMID   11329368.
3. Verhagen AM, Coulson EJ, Vaux DL (2001). "Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs". Genome Biol. 2 (7) REVIEWS3009. doi: 10.1186/gb-2001-2-7-reviews3009 . PMC   139420 . PMID   11516343.
4. Birnbaum MJ, Clem RJ, Miller LK (April 1994). "An apoptosis-inhibiting gene from a nuclear polyhedrosis virus encoding a polypeptide with Cys/His sequence motifs". J. Virol. 68 (4): 2521–8. doi:10.1128/JVI.68.4.2521-2528.1994. PMC   236730 . PMID   8139034.

This article incorporates text from the public domain Pfam and InterPro: IPR001370