BIRC6

BIRC6
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3CEG
Identifiers
Aliases	BIRC6 , APOLLON, BRUCE, baculoviral IAP repeat containing 6
External IDs	OMIM: 605638 MGI: 1276108 HomoloGene: 7248 GeneCards: BIRC6
Gene location (Human)
Chr.	Chromosome 2 (human)
End	32,618,878 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	75,010,351 bp
RNA expression pattern
	Top expressed in
	pancreatic epithelial cell; ; Achilles tendon; ; pancreatic ductal cell; ; tibialis anterior muscle; ; bone marrow cells; ; corpus callosum; ; seminal vesicula; ; ganglionic eminence; ; thymus; ; sural nerve;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; thymus; ; seminal vesicula; ; cumulus cell; ; submandibular gland; ; ascending aorta; ; lacrimal gland; ; yolk sac; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	peptidase inhibitor activity ; cysteine-type endopeptidase inhibitor activity ; ubiquitin-protein transferase activity ; protein binding ; ubiquitin conjugating enzyme activity ; transferase activity ;
Cellular component	cytoplasm ; endosome ; spindle pole ; membrane ; microtubule organizing center ; trans-Golgi network ; cytoskeleton ; Golgi apparatus ; intracellular membrane-bounded organelle ; midbody ; Flemming body ; nucleus ;
Biological process	negative regulation of peptidase activity ; spongiotrophoblast layer development ; regulation of cytokinesis ; placenta development ; labyrinthine layer development ; negative regulation of extrinsic apoptotic signaling pathway ; negative regulation of apoptotic process ; cell division ; protein phosphorylation ; regulation of cell population proliferation ; protein ubiquitination ; positive regulation of cell population proliferation ; cell cycle ; apoptotic process ; negative regulation of endopeptidase activity ; ubiquitin-dependent protein catabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	57448
	12211
	ENSG00000115760
	ENSMUSG00000024073
	Q9NR09
	O88738
	NM_016252 ; NM_001378125
	NM_007566
	NP_057336 ; NP_001365054
	NP_031592 ; NP_001389698
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Baculoviral IAP repeat-containing protein 6 is a protein that in humans is encoded by the BIRC6 gene.^[5]^[6]

Function

This gene encodes a protein with a BIR (baculoviral inhibition of apoptosis protein repeat) domain and a UBCc (ubiquitin-conjugating enzyme E2, catalytic) domain. This protein inhibits apoptosis by facilitating the degradation of apoptotic proteins by ubiquitination.^[6]

Interactions

BIRC6 has been shown to interact with KIF23.^[7]

Diseases

BIRC6 is implicated in leukemia, melanoma, breast cancer, lung cancer, colorectal cancer, and other cancers^[8] (see the Atlas of Genetics and Cytogenetics in Oncology and Haematology ^[9]).

Related Research Articles

Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome.

Baculoviral IAP repeat-containing protein3 is a protein that in humans is encoded by the BIRC3 gene.

Baculoviral IAP repeat-containing protein 2 is a protein that in humans is encoded by the BIRC2 gene.

Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.

Diablo homolog (DIABLO) is a mitochondrial protein that in humans is encoded by the DIABLO gene on chromosome 12. DIABLO is also referred to as second mitochondria-derived activator of caspases or SMAC. This protein binds inhibitor of apoptosis proteins (IAPs), thus freeing caspases to activate apoptosis. Due to its proapoptotic function, SMAC is implicated in a broad spectrum of tumors, and small molecule SMAC mimetics have been developed to enhance current cancer treatments.

Baculoviral IAP repeat-containing protein 7 is a protein that in humans is encoded by the BIRC7 gene.

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.

XIAP-associated factor 1 is a protein that in humans is encoded by the XAF1 gene.

Baculoviral IAP repeat-containing protein 1 is a protein that in humans is encoded by the NAIP gene.

Ubiquitin-conjugating enzyme E2 variant 1 is a protein that in humans is encoded by the UBE2V1 gene.

Autophagy related 12 is a protein that in humans is encoded by the ATG12 gene.

E3 ubiquitin-protein ligase NRDP1 is an enzyme that in humans is encoded by the RNF41 gene.

Tripartite motif-containing protein 32 is a protein that in humans is encoded by the TRIM32 gene. Since its discovery in 1995, TRIM32 has been shown to be implicated in a number of diverse biological pathways.

F-box/LRR-repeat protein 7 is a protein that in humans is encoded by the FBXL7 gene.

G2/M phase-specific E3 ubiquitin-protein ligase is an enzyme that in humans is encoded by the G2E3 gene.

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.

Cell migration-inducing and hyaluronan-binding protein (CEMIP), formerly known as KIAA1199, is a protein that in humans is encoded by the CEMIP gene. CEMIP has been shown to bind hyaluronic acid and catalyze its depolymerization independently of CD44 and hyaluronidases. Such function has been also been validated in mice.

The inhibitor of apoptosis domain -- also known as IAP repeat, Baculovirus Inhibitor of apoptosis protein Repeat, or BIR -- is a structural motif found in proteins with roles in apoptosis, cytokine production, and chromosome segregation. Proteins containing BIR are known as inhibitor of apoptosis proteins (IAPs), or BIR-containing proteins, and include BIRC1 (NAIP), BIRC2 (cIAP1), BIRC3 (cIAP2), BIRC4 (xIAP), BIRC5 (survivin) and BIRC6.

cIAP1 is the abbreviation for a human protein, cellular inhibitor of apoptosis protein-1. It belongs to the IAP family of proteins and therefore contains at least one BIR domain. cIAP1 is a multi-functional protein which can be found in the cytoplasm of cells and in the nucleus of tumor cells. Its function in this particular case is yet to be understood. However, it is well-known that this protein has a big influence in the growth of diverse cancers. cIAP1 is involved in the development process of osteosarcoma and gastric cancer among others.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115760 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024073 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.
1 2 "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)".
↑ Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell. 132 (5): 832–45. doi: 10.1016/j.cell.2008.01.012 . PMID 18329369. S2CID 12192141.
↑ "BIRC6 (Baculoviral IAP repeat-containing 6)". atlasgeneticsoncology.org.
↑ "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.

External links

Human BIRC6 genome location and BIRC6 gene details page in the UCSC Genome Browser .
PDBe-KB provides an overview of all the structure information available in the PDB for Human Baculoviral IAP repeat-containing protein 6

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi: 10.1093/dnares/9.3.99 . PMID 12168954.
Adams MD, Kerlavage AR, Fleischmann RD, Fuldner RA, Bult CJ, Lee NH, Kirkness EF, Weinstock KG, Gocayne JD, White O (1995). "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence" (PDF). Nature. 377 (6547 Suppl): 3–174. PMID 7566098.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.
Nagase T, Ishikawa K, Kikuno R, Hirosawa M, Nomura N, Ohara O (2000). "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (5): 337–45. doi: 10.1093/dnares/6.5.337 . PMID 10574462.
Qiu XB, Markant SL, Yuan J, Goldberg AL (2005). "Nrdp1-mediated degradation of the gigantic IAP, BRUCE, is a novel pathway for triggering apoptosis". EMBO J. 23 (4): 800–10. doi:10.1038/sj.emboj.7600075. PMC 380992 . PMID 14765125.
Bartke T, Pohl C, Pyrowolakis G, Jentsch S (2005). "Dual role of BRUCE as an antiapoptotic IAP and a chimeric E2/E3 ubiquitin ligase". Mol. Cell. 14 (6): 801–11. doi: 10.1016/j.molcel.2004.05.018 . PMID 15200957.
Hao Y, Sekine K, Kawabata A, Nakamura H, Ishioka T, Ohata H, Katayama R, Hashimoto C, Zhang X, Noda T, Tsuruo T, Naito M (2004). "Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function". Nat. Cell Biol. 6 (9): 849–60. doi:10.1038/ncb1159. PMID 15300255. S2CID 22850781.
Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Mol. Cell. Biol. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982 . PMID 15314180.
Qiu XB, Goldberg AL (2005). "The membrane-associated inhibitor of apoptosis protein, BRUCE/Apollon, antagonizes both the precursor and mature forms of Smac and caspase-9". J. Biol. Chem. 280 (1): 174–82. doi: 10.1074/jbc.M411430200 . PMID 15507451.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115760 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024073 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10544019-5] Chen Z, Naito M, Hori S, Mashima T, Yamori T, Tsuruo T (Dec 1999). "A human IAP-family gene, apollon, expressed in human brain cancer cells". Biochem Biophys Res Commun. 264 (3): 847–54. doi:10.1006/bbrc.1999.1585. PMID 10544019.

[entrez-6] 1 2 "Entrez Gene: BIRC6 baculoviral IAP repeat-containing 6 (apollon)".

[pmid18329369-7] Pohl C, Jentsch S (Mar 2008). "Final stages of cytokinesis and midbody ring formation are controlled by BRUCE". Cell. 132 (5): 832–45. doi: 10.1016/j.cell.2008.01.012 . PMID 18329369. S2CID 12192141.

[8] "BIRC6 (Baculoviral IAP repeat-containing 6)". atlasgeneticsoncology.org.

[9] "Atlas of Genetics and Cytogenetics in Oncology and Haematology". atlasgeneticsoncology.org.

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