UBE2H

Last updated
UBE2H
Protein UBE2H PDB 1yh6.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBE2H , E2-20K, GID3, UBC8, UBCH, UBCH2, ubiquitin conjugating enzyme E2 H
External IDs OMIM: 601082 MGI: 104632 HomoloGene: 103894 GeneCards: UBE2H
EC number 2.3.2.24
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001202498
NM_003344
NM_182697

NM_001169576
NM_001169577
NM_009459

RefSeq (protein)

NP_001189427
NP_003335
NP_874356
NP_003335.1

NP_001163047
NP_001163048
NP_033485

Location (UCSC) Chr 7: 129.83 – 129.95 Mb Chr 6: 30.21 – 30.3 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene. [5] [6]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms. [6]

Related Research Articles

<span class="mw-page-title-main">UBE2N</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 N is a protein that in humans is encoded by the UBE2N gene.

<span class="mw-page-title-main">UBE2D1</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.

<span class="mw-page-title-main">UBE2D2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the UBE2D2 gene.

<span class="mw-page-title-main">UBE2D3</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 D3 is a protein that in humans is encoded by the UBE2D3 gene.

<span class="mw-page-title-main">UBE2G2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.

<span class="mw-page-title-main">UBE2V2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene. Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family.

<span class="mw-page-title-main">UBE1C</span> Protein-coding gene in the species Homo sapiens

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.

<span class="mw-page-title-main">UBE2E3</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.

<span class="mw-page-title-main">UBE2L6</span> Protein-coding gene in the species Homo sapiens

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.

<span class="mw-page-title-main">UBE2A</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.

<span class="mw-page-title-main">UBE2B</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.

<span class="mw-page-title-main">UBE2C</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

<span class="mw-page-title-main">UBE4B</span> Protein-coding gene in the species Homo sapiens

Ubiquitin conjugation factor E4 B is a protein that in humans is encoded by the UBE4B gene.

<span class="mw-page-title-main">UBE2G1</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.

<span class="mw-page-title-main">UBE1L</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene.

<span class="mw-page-title-main">UBE2J1</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.

<span class="mw-page-title-main">UBE2E2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 E2 is a protein that in humans is encoded by the UBE2E2 gene.

<span class="mw-page-title-main">UBE2M</span> Protein-coding gene in the species Homo sapiens

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

<span class="mw-page-title-main">UBE4A</span> Protein-coding gene in the species Homo sapiens

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.

<span class="mw-page-title-main">UBE2R2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000186591 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000039159 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R (Apr 1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8". J Biol Chem. 269 (12): 8797–802. doi: 10.1016/S0021-9258(17)37039-4 . PMID   8132613.
  6. 1 2 "Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)".

Further reading