UBE2E1

UBE2E1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1XR9, 3BZH, 4JJQ
Identifiers
Aliases	UBE2E1 , UBCH6, ubiquitin conjugating enzyme E2 E1
External IDs	OMIM: 602916; MGI: 107411; HomoloGene: 84372; GeneCards: UBE2E1; OMA:UBE2E1 - orthologs
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 3 (human) [1] Band 3p24.2 Start 23,805,955 bp [1] End 23,891,640 bp [1]
Gene location (Mouse) Chr. Chromosome 14 (mouse) [2] Band 14|14 A1 Start 4,137,837 bp [2] End 4,186,974 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue oral cavity ventricular zone embryo skin of arm superficial temporal artery bronchial epithelial cell mucosa of paranasal sinus pons lower lobe of lung Top expressed in otic placode otic vesicle saccule mammillary body ventral tegmental area dorsomedial hypothalamic nucleus arcuate nucleus paraventricular nucleus of hypothalamus nasal epithelium olfactory epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ISG15 transferase activity ubiquitin-protein transferase activity protein binding ATP binding ubiquitin conjugating enzyme activity Cellular component cytosol ubiquitin ligase complex nucleoplasm nucleus Biological process histone monoubiquitination ubiquitin-dependent protein catabolic process protein polyubiquitination protein K48-linked ubiquitination ISG15-protein conjugation anaphase-promoting complex-dependent catabolic process histone H2B ubiquitination protein ubiquitination regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7324 22194 Ensembl ENSG00000170142 ENSMUSG00000021774 UniProt P51965 P52482 RefSeq (mRNA) NM_001202476 NM_003341 NM_182666 NM_009455 RefSeq (protein) NP_001189405 NP_003332 NP_872607 NP_003332.1 NP_033481 Location (UCSC) Chr 3: 23.81 – 23.89 Mb Chr 14: 4.14 – 4.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene. ^{[5] [6]}

Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ^[6]

Interactions

UBE2E1 has been shown to interact with Ataxin 1 ^[7] and NEDD4. ^{[8] [9]}

References

1. GRCh38: Ensembl release 89: ENSG00000170142 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021774 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J. Biol. Chem. 271 (5): 2795–800. doi: 10.1074/jbc.271.5.2795 . PMID   8576257.
6. "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)".
7. Hong S, Lee S, Cho SG, Kang S (Jun 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. 371 (2): 256–60. doi:10.1016/j.bbrc.2008.04.066. PMID   18439907.
8. Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID   9990509. S2CID   1653536.
9. Malakhova OA, Zhang DE (Apr 2008). "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response". J. Biol. Chem. 283 (14): 8783–7. doi: 10.1074/jbc.C800030200 . PMC   2276364 . PMID   18287095.

Further reading

• Pickart CM (2001). "Mechanisms underlying ubiquitination". Annu. Rev. Biochem. 70: 503–33. doi:10.1146/annurev.biochem.70.1.503. PMID   11395416.
• Chen P, Johnson P, Sommer T, Jentsch S, Hochstrasser M (1993). "Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor". Cell. 74 (2): 357–69. doi:10.1016/0092-8674(93)90426-Q. PMID   8393731. S2CID   205020910.
• Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID   9990509. S2CID   1653536.
• Nyman TA, Matikainen S, Sareneva T, Julkunen I, Kalkkinen N (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes". Eur. J. Biochem. 267 (13): 4011–9. doi: 10.1046/j.1432-1327.2000.01433.x . PMID   10866800.
• Lenk U, Sommer T (2000). "Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization". J. Biol. Chem. 275 (50): 39403–10. doi: 10.1074/jbc.M006949200 . PMID   10991948.
• Pringa E, Martinez-Noel G, Muller U, Harbers K (2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes". J. Biol. Chem. 276 (22): 19617–23. doi: 10.1074/jbc.M100192200 . PMID   11274149.
• Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi: 10.1046/j.1432-1327.2001.02169.x . PMID   11322894.
• Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.
• Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H (2005). "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID   16428300.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Ubiquitin-conjugating enzyme E2 E1 (UBE2E1)