UBE2L6

UBE2L6
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1WZV, 1WZW, 2KJH
Identifiers
Aliases	UBE2L6 , RIG-B, UBCH8, ubiquitin conjugating enzyme E2 L6
External IDs	OMIM: 603890 MGI: 1914500 HomoloGene: 3112 GeneCards: UBE2L6
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.1 Start 57,551,656 bp [1] End 57,568,284 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2|2 D Start 84,629,172 bp [2] End 84,640,679 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte palpebral conjunctiva ganglionic eminence lymph node spleen appendix gallbladder stromal cell of endometrium blood right lung Top expressed in blood yolk sac spleen blastocyst duodenum jejunum aortic valve ascending aorta lip morula More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ubiquitin-like protein transferase activity transferase activity ISG15 transferase activity protein binding ubiquitin-protein transferase activity ubiquitin binding ubiquitin protein ligase binding ubiquitin conjugating enzyme activity Cellular component cytosol nucleoplasm ubiquitin ligase complex Biological process ISG15-protein conjugation translesion synthesis negative regulation of type I interferon production modification-dependent protein catabolic process protein ubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9246 56791 Ensembl ENSG00000156587 ENSMUSG00000027078 UniProt O14933 Q9QZU9 RefSeq (mRNA) NM_198183 NM_004223 NM_019949 RefSeq (protein) NP_004214 NP_937826 NP_064333 Location (UCSC) Chr 11: 57.55 – 57.57 Mb Chr 2: 84.63 – 84.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene. ^{[5] [6]}

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1S), ubiquitin-conjugating enzymes (E2S) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family.

This enzyme is highly similar in primary structure to the enzyme encoded by UBE2L3 gene. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000156587 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027078 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Kumar S, Kao WH, Howley PM (Jul 1997). "Physical interaction between specific E2 and Hect E3 enzymes determines functional cooperativity". J Biol Chem. 272 (21): 13548–54. doi: 10.1074/jbc.272.21.13548 . PMID   9153201.
6. "Entrez Gene: UBE2L6 ubiquitin-conjugating enzyme E2L 6".

Further reading

• Kang HY, Yeh S, Fujimoto N, Chang C (1999). "Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor". J. Biol. Chem. 274 (13): 8570–6. doi: 10.1074/jbc.274.13.8570 . PMID   10085091.
• Moynihan TP, Ardley HC, Nuber U, et al. (1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J. Biol. Chem. 274 (43): 30963–8. doi: 10.1074/jbc.274.43.30963 . PMID   10521492.
• Huang L, Kinnucan E, Wang G, et al. (1999). "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade". Science. 286 (5443): 1321–6. doi:10.1126/science.286.5443.1321. PMID   10558980.
• Nyman TA, Matikainen S, Sareneva T, et al. (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes". Eur. J. Biochem. 267 (13): 4011–9. doi: 10.1046/j.1432-1327.2000.01433.x . PMID   10866800.
• Ardley HC, Rose SA, Tan N, et al. (2000). "Genomic organization of the human ubiquitin-conjugating enzyme gene, UBE2L6 on chromosome 11q12". Cytogenet. Cell Genet. 89 (1–2): 137–40. doi:10.1159/000015593. PMID   10894956. S2CID   502452.
• Zhang Y, Gao J, Chung KK, et al. (2001). "Parkin functions as an E2-dependent ubiquitin- protein ligase and promotes the degradation of the synaptic vesicle-associated protein, CDCrel-1". Proc. Natl. Acad. Sci. U.S.A. 97 (24): 13354–9. doi: 10.1073/pnas.240347797 . PMC   27228 . PMID   11078524.
• Niwa J, Ishigaki S, Doyu M, et al. (2001). "A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity". Biochem. Biophys. Res. Commun. 281 (3): 706–13. doi:10.1006/bbrc.2001.4414. PMID   11237715.
• Wheeler TC, Chin LS, Li Y, et al. (2002). "Regulation of synaptophysin degradation by mammalian homologues of seven in absentia". J. Biol. Chem. 277 (12): 10273–82. doi: 10.1074/jbc.M107857200 . PMID   11786535.
• Urano T, Saito T, Tsukui T, et al. (2002). "Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth". Nature. 417 (6891): 871–5. Bibcode:2002Natur.417..871U. doi:10.1038/nature00826. PMID   12075357. S2CID   4348545.
• Chin LS, Vavalle JP, Li L (2002). "Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation". J. Biol. Chem. 277 (38): 35071–9. doi: 10.1074/jbc.M203300200 . PMID   12121982.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID   15107846. S2CID   39773935.
• Zhao C, Beaudenon SL, Kelley ML, et al. (2004). "The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein". Proc. Natl. Acad. Sci. U.S.A. 101 (20): 7578–82. Bibcode:2004PNAS..101.7578Z. doi: 10.1073/pnas.0402528101 . PMC   419648 . PMID   15131269.
• Tripathi MK, Chaudhuri G (2005). "Down-regulation of UCRP and UBE2L6 in BRCA2 knocked-down human breast cells". Biochem. Biophys. Res. Commun. 328 (1): 43–8. doi:10.1016/j.bbrc.2004.12.142. PMC   3085986 . PMID   15670748.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Li J, Wang J, Yang X, et al. (2007). "The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8". Mol. Cell. Biochem. 288 (1–2): 151–7. doi:10.1007/s11010-006-9131-9. PMID   16583136. S2CID   24935755.