UBE2B

Last updated
UBE2B
Protein UBE2B PDB 1jas.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases UBE2B , E2-17kDa, HHR6B, HR6B, RAD6B, UBC2, ubiquitin conjugating enzyme E2 B
External IDs OMIM: 179095 MGI: 102944 HomoloGene: 101298 GeneCards: UBE2B
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003337

NM_009458
NM_001362685
NM_001362686

RefSeq (protein)

NP_003328

NP_033484
NP_001349614
NP_001349615

Location (UCSC) Chr 5: 134.37 – 134.39 Mb Chr 11: 51.88 – 51.89 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene. [5] [6]

Contents

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution. [6]

Interactions

UBE2B has been shown to interact with RAD18. [7] [8]

Related Research Articles

<span class="mw-page-title-main">UBE2I</span> Protein-coding gene in the species Homo sapiens

SUMO-conjugating enzyme UBC9 is an enzyme that in humans is encoded by the UBE2I gene. It is also sometimes referred to as "ubiquitin conjugating enzyme E2I" or "ubiquitin carrier protein 9", even though these names do not accurately describe its function.

<span class="mw-page-title-main">RAD23A</span> Protein-coding gene in the species Homo sapiens

UV excision repair protein RAD23 homolog A is a protein that in humans is encoded by the RAD23A gene.

<span class="mw-page-title-main">RAD23B</span> Protein-coding gene in the species Homo sapiens

UV excision repair protein RAD23 homolog B is a protein that in humans is encoded by the RAD23B gene.

<span class="mw-page-title-main">CDC34</span> Protein-coding gene in the species Homo sapiens

CDC34 is a gene that in humans encodes the protein Ubiquitin-conjugating enzyme E2 R1. This protein is a member of the ubiquitin-conjugating enzyme family, which catalyzes the covalent attachment of ubiquitin to other proteins.

<span class="mw-page-title-main">RAD18</span> Protein-coding gene in the species Homo sapiens

E3 ubiquitin-protein ligase RAD18 is an enzyme that in humans is encoded by the RAD18 gene.

<span class="mw-page-title-main">UBE2G2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.

<span class="mw-page-title-main">UBE1C</span> Protein-coding gene in the species Homo sapiens

NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene.

<span class="mw-page-title-main">UBE2E3</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 E3 is a protein that in humans is encoded by the UBE2E3 gene.

<span class="mw-page-title-main">UBE2L6</span> Protein-coding gene in the species Homo sapiens

Ubiquitin/ISG15-conjugating enzyme E2 L6 is a protein that in humans is encoded by the UBE2L6 gene.

<span class="mw-page-title-main">UBE2A</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.

<span class="mw-page-title-main">UBE2C</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.

<span class="mw-page-title-main">UBE2G1</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.

<span class="mw-page-title-main">UBE2H</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.

<span class="mw-page-title-main">ATG12</span> Protein-coding gene in the species Homo sapiens

Autophagy related 12 is a protein that in humans is encoded by the ATG12 gene.

<span class="mw-page-title-main">Kua-UEV</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 variant 1, also known as Kua-UEV, is a human gene.

<span class="mw-page-title-main">UBE2J1</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.

<span class="mw-page-title-main">UBE2E2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 E2 is a protein that in humans is encoded by the UBE2E2 gene.

<span class="mw-page-title-main">UBE2M</span> Protein-coding gene in the species Homo sapiens

NEDD8-conjugating enzyme Ubc12 is a protein that in humans is encoded by the UBE2M gene.

<span class="mw-page-title-main">UFM1</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-fold modifier 1, also known as UFM1, is a protein which in humans is encoded by the UFM1 gene.

<span class="mw-page-title-main">UBE2R2</span> Protein-coding gene in the species Homo sapiens

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000119048 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020390 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics. 12 (3): 447–53. doi:10.1016/0888-7543(92)90433-S. hdl: 1765/3036 . PMID   1559696.
  6. 1 2 "Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)".
  7. Xin, H; Lin W; Sumanasekera W; Zhang Y; Wu X; Wang Z (July 2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. ENGLAND. 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC   102657 . PMID   10908344.
  8. Tateishi, S; Sakuraba Y; Masuyama S; Inoue H; Yamaizumi M (July 2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (14): 7927–32. Bibcode:2000PNAS...97.7927T. doi: 10.1073/pnas.97.14.7927 . ISSN   0027-8424. PMC   16647 . PMID   10884424.

Further reading