UBE2C

UBE2C
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1I7K, 4YII, 5A31
Identifiers
Aliases	UBE2C , UBCH10, dJ447F3.2, ubiquitin conjugating enzyme E2 C
External IDs	OMIM: 605574 MGI: 1915862 HomoloGene: 5096 GeneCards: UBE2C
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 20 (human) [1] Band 20q13.12 Start 45,812,576 bp [1] End 45,816,957 bp [1]
Gene location (Mouse) Chr. Chromosome 2 (mouse) [2] Band 2 H3|2 85.27 cM Start 164,611,818 bp [2] End 164,620,742 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in embryo ganglionic eminence oocyte bone marrow secondary oocyte thymus cancellous bone rectum bone marrow cells stromal cell of endometrium Top expressed in medial ganglionic eminence somite otic placode abdominal wall morula blood hand endocardial cushion thymus maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ubiquitin protein ligase activity ubiquitin-protein transferase activity protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding Cellular component cytoplasm nucleoplasm anaphase-promoting complex cytosol plasma membrane ubiquitin ligase complex nucleus Biological process free ubiquitin chain polymerization ubiquitin-dependent protein catabolic process exit from mitosis positive regulation of exit from mitosis protein K11-linked ubiquitination cell division protein K48-linked ubiquitination regulation of mitotic metaphase/anaphase transition cell cycle anaphase-promoting complex-dependent catabolic process positive regulation of ubiquitin protein ligase activity protein ubiquitination regulation of mitotic cell cycle phase transition Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11065 68612 Ensembl ENSG00000175063 ENSMUSG00000001403 UniProt O00762 Q5TZN3 Q9D1C1 RefSeq (mRNA) NM_001281741 NM_001281742 NM_007019 NM_181799 NM_181800 NM_181801 NM_181802 NM_181803 NM_026785 RefSeq (protein) NP_001268670 NP_001268671 NP_008950 NP_861515 NP_861516 NP_861517 NP_008950.1 NP_081061 Location (UCSC) Chr 20: 45.81 – 45.82 Mb Chr 2: 164.61 – 164.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene. ^{[5] [6]}

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000175063 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000001403 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A. 94 (6): 2362–7. Bibcode:1997PNAS...94.2362T. doi: 10.1073/pnas.94.6.2362 . PMC   20093 . PMID   9122200.
6. "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C".

Further reading

• Fossey SC, Mychaleckyj JC, Pendleton JK, et al. (2001). "A high-resolution 6.0-megabase transcript map of the type 2 diabetes susceptibility region on human chromosome 20". Genomics. 76 (1–3): 45–57. doi:10.1006/geno.2001.6584. PMID   11549316.
• Tang Z, Li B, Bharadwaj R, et al. (2002). "APC2 Cullin protein and APC11 RING protein comprise the minimal ubiquitin ligase module of the anaphase-promoting complex". Mol. Biol. Cell. 12 (12): 3839–51. doi:10.1091/mbc.12.12.3839. PMC   60759 . PMID   11739784.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID   11780052.
• Lin Y, Hwang WC, Basavappa R (2002). "Structural and functional analysis of the human mitotic-specific ubiquitin-conjugating enzyme, UbcH10". J. Biol. Chem. 277 (24): 21913–21. doi: 10.1074/jbc.M109398200 . PMID   11927573.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Okamoto Y, Ozaki T, Miyazaki K, et al. (2003). "UbcH10 is the cancer-related E2 ubiquitin-conjugating enzyme". Cancer Res. 63 (14): 4167–73. PMID   12874022.
• Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID   15107846. S2CID   39773935.
• Wagner KW, Sapinoso LM, El-Rifai W, et al. (2004). "Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin". Oncogene. 23 (39): 6621–9. doi: 10.1038/sj.onc.1207861 . PMID   15208666.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Le XF, Lammayot A, Gold D, et al. (2005). "Genes affecting the cell cycle, growth, maintenance, and drug sensitivity are preferentially regulated by anti-HER2 antibody through phosphatidylinositol 3-kinase-AKT signaling". J. Biol. Chem. 280 (3): 2092–104. doi: 10.1074/jbc.M403080200 . PMID   15504738.
• Pallante P, Berlingieri MT, Troncone G, et al. (2005). "UbcH10 overexpression may represent a marker of anaplastic thyroid carcinomas". Br. J. Cancer. 93 (4): 464–71. doi:10.1038/sj.bjc.6602721. PMC   2361574 . PMID   16106252.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Takahashi Y, Ishii Y, Nishida Y, et al. (2006). "Detection of aberrations of ubiquitin-conjugating enzyme E2C gene (UBE2C) in advanced colon cancer with liver metastases by DNA microarray and two-color FISH". Cancer Genet. Cytogenet. 168 (1): 30–5. doi:10.1016/j.cancergencyto.2005.12.011. PMID   16772118.
• Lin J, Raoof DA, Wang Z, et al. (2007). "Expression and effect of inhibition of the ubiquitin-conjugating enzyme E2C on esophageal adenocarcinoma". Neoplasia. 8 (12): 1062–71. doi:10.1593/neo.05832. PMC   1783715 . PMID   17217624.
• Ieta K, Ojima E, Tanaka F, et al. (2007). "Identification of overexpressed genes in hepatocellular carcinoma, with special reference to ubiquitin-conjugating enzyme E2C gene expression". Int. J. Cancer. 121 (1): 33–8. doi: 10.1002/ijc.22605 . PMID   17354233. S2CID   12277353.