UBE2R2

UBE2R2
Identifiers
Aliases	UBE2R2 , CDC34B, E2-CDC34B, UBC3B, ubiquitin conjugating enzyme E2 R2
External IDs	OMIM: 612506 MGI: 1914865 HomoloGene: 3210 GeneCards: UBE2R2
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p13.3 Start 33,817,160 bp [1] End 33,920,399 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A5 Start 41,135,743 bp [2] End 41,193,380 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm secondary oocyte tibialis anterior muscle nipple quadriceps femoris muscle vastus lateralis muscle deltoid muscle inferior ganglion of vagus nerve right ventricle vulva Top expressed in blood ascending aorta aortic valve internal carotid artery external carotid artery plantaris muscle lip extensor digitorum longus muscle corneal stroma skeletal muscle tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity Cellular component cytoplasm cytosol Biological process protein K48-linked ubiquitination protein monoubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process protein ubiquitination protein polyubiquitination ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54926 67615 Ensembl ENSG00000107341 ENSMUSG00000036241 UniProt Q712K3 Q6ZWZ2 RefSeq (mRNA) NM_017811 NM_026275 RefSeq (protein) NP_060281 NP_080551 Location (UCSC) Chr 9: 33.82 – 33.92 Mb Chr 4: 41.14 – 41.19 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene. ^{[5] [6]}

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000107341 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036241 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Semplici F, Meggio F, Pinna LA, Oliviero S (May 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. 21 (25): 3978–87. doi: 10.1038/sj.onc.1205574 . PMID   12037680.
6. "Entrez Gene: UBE2R2 ubiquitin-conjugating enzyme E2R 2".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi: 10.1073/pnas.97.7.3491 . PMC   16267 . PMID   10737800.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID   15146197. S2CID   27764390.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.