DNAJC13

DNAJC13
Identifiers
Aliases	DNAJC13 , RME8, PARK21, DnaJ heat shock protein family (Hsp40) member C13
External IDs	OMIM: 614334 MGI: 2676368 HomoloGene: 13574 GeneCards: DNAJC13
Gene location (Human)
Chr.	Chromosome 3 (human)
End	132,539,032 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	104,140,129 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; saphenous vein; ; cancellous bone; ; superficial temporal artery; ; parietal pleura; ; trigeminal ganglion; ; tibia; ; visceral pleura; ; stromal cell of endometrium; ; germinal epithelium;
	Top expressed in
	secondary oocyte; ; cumulus cell; ; saccule; ; otic placode; ; kidney; ; ileum; ; ciliary body; ; morula; ; cochlea; ; placenta;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding ;
Cellular component	lysosomal membrane ; endosome ; WASH complex ; early endosome membrane ; endosome membrane ; extracellular exosome ; early endosome ; membrane ; intracellular membrane-bounded organelle ; cytosol ; plasma membrane ; secretory granule membrane ; azurophil granule membrane ;
Biological process	protein transport ; regulation of early endosome to late endosome transport ; regulation of early endosome to recycling endosome transport ; osteoblast differentiation ; endosome organization ; neutrophil degranulation ; receptor-mediated endocytosis ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	23317
	235567
	ENSG00000138246
	ENSMUSG00000032560
	O75165
	n/a
	NM_015268 ; NM_001329126 ; NM_173823
	NM_001163026 ; NM_001359740
	NP_001316055 ; NP_056083
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

DnaJ (Hsp40) homolog, subfamily C, member 13, also known as DNAJC13, is a human gene.^[5]

Related Research Articles

DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.

DnaJ homolog subfamily B member 11 is a protein that in humans is encoded by the DNAJB11 gene.

DnaJ homolog subfamily B member 9 is a protein that in humans is encoded by the DNAJB9 gene.

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.

Nucleoporin 160 (Nup160) is a protein that in humans is encoded by the NUP160 gene.

Proto-oncogene serine/threonine-protein kinase mos is an enzyme that in humans is encoded by the MOS gene.

DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the DNAJC7 gene.

DnaJ homolog subfamily C member 2 is a protein that in humans is encoded by the DNAJC2 gene.

DnaJ homolog subfamily C member 10 is a protein that in humans is encoded by the DNAJC10 gene.

DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene.

Putative rRNA methyltransferase 3 is an enzyme that in humans is encoded by the FTSJ3 gene.

Zinc finger protein 7 is a protein that in humans is encoded by the ZNF7 gene.

DnaJ homolog subfamily C member 14 is a protein that in humans is encoded by the DNAJC14 gene.

Mitochondrial import receptor subunit TOM70 is a protein that in humans is encoded by the TOMM70A gene.

DnaJ homolog subfamily C member 28 is a protein that in humans is encoded by the DNAJC28 gene. It's a member of chaperone DnaJ family. The family is also known as Hsp40.

DnaJ homolog subfamily C member 11 is a protein that in humans is encoded by the DNAJC11 gene.

Protein unc-45 homolog A is a protein that in humans is encoded by the UNC45A gene.

DnaJ homolog subfamily C member 1 is a protein that in humans is encoded by the DNAJC1 gene.

UDP-N-acetylglucosamine transferase subunit ALG14 homolog is a protein that in humans is encoded by the ALG14 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000138246 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032560 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13".

Girard M, Poupon V, Blondeau F, McPherson PS (2006). "The DnaJ-domain protein RME-8 functions in endosomal trafficking". J. Biol. Chem. 280 (48): 40135–43. doi: 10.1074/jbc.M505036200 . PMID 16179350.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC 514446 . PMID 15302935.
Chang HC, Hull M, Mellman I (2004). "The J-domain protein Rme-8 interacts with Hsc70 to control clathrin-dependent endocytosis in Drosophila". J. Cell Biol. 164 (7): 1055–64. doi:10.1083/jcb.200311084. PMC 2172058 . PMID 15051737.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Volz A, Melkaoui R, Hildebrandt F, Omran H (2003). "Candidate gene analysis of KIAA0678 encoding a DnaJ-like protein for adolescent nephronophthisis and Senior-Løken syndrome type 3". Cytogenet. Genome Res. 97 (3–4): 163–6. doi:10.1159/000066617. PMID 12438707. S2CID 438753.
Ishikawa K, Nagase T, Suyama M, et al. (1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi: 10.1093/dnares/5.3.169 . PMID 9734811.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000138246 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032560 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: DNAJC13 DnaJ (Hsp40) homolog, subfamily C, member 13".

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DNAJC13

Related Research Articles

References

Further reading