UBE2O

UBE2O
Identifiers
Aliases	UBE2O , E2-230K, ubiquitin conjugating enzyme E2 O
External IDs	OMIM: 617649; MGI: 2444266; HomoloGene: 11113; GeneCards: UBE2O; OMA:UBE2O - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.1 Start 76,389,456 bp [1] End 76,453,152 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E2 Start 116,428,566 bp [2] End 116,472,273 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe apex of heart prefrontal cortex gastrocnemius muscle Brodmann area 9 ganglionic eminence stromal cell of endometrium islet of Langerhans right lobe of thyroid gland Top expressed in blood tibiofemoral joint primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell perirhinal cortex entorhinal cortex fetal liver hematopoietic progenitor cell CA3 field central gray substance of midbrain More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein binding ATP binding ubiquitin conjugating enzyme activity ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin-protein transferase activity RNA binding Cellular component cytoplasm nucleus cytosol nuclear body Biological process positive regulation of BMP signaling pathway protein K63-linked ubiquitination retrograde transport, endosome to Golgi protein monoubiquitination protein ubiquitination transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 63893 217342 Ensembl ENSG00000175931 ENSMUSG00000020802 UniProt Q9C0C9 Q6ZPJ3 RefSeq (mRNA) NM_022066 NM_173755 RefSeq (protein) NP_071349 NP_776116 Location (UCSC) Chr 17: 76.39 – 76.45 Mb Chr 11: 116.43 – 116.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 O is a protein that in humans is encoded by the UBE2O gene. ^{[5] [6] [7]}

UBE2O functions during terminal erythroid differentiation to eliminate generic cellular components in parallel with abundant synthesis of hemoglobin. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000175931 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020802 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Yokota T, Nagai H, Harada H, Mine N, Terada Y, Fujiwara H, Yabe A, Miyazaki K, Emi M (Apr 2001). "Identification, tissue expression, and chromosomal position of a novel gene encoding human ubiquitin-conjugating enzyme E2-230k". Gene. 267 (1): 95–100. doi:10.1016/S0378-1119(01)00407-3. PMID   11311559.
6. Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Feb 2001). "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. doi: 10.1093/dnares/7.6.347 . PMID   11214970.
7. "Entrez Gene: UBE2O ubiquitin-conjugating enzyme E2O".
8. Nguyen AT, Prado MA, et al. (2017). "UBE2O remodels the proteome during terminal erythroid differentiation". Science. 357 (6350) eaan0218. doi:10.1126/science.aan0218. PMC   5812729 . PMID   28774900.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tomsig JL, Snyder SL, Creutz CE (2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". J. Biol. Chem. 278 (12): 10048–54. doi: 10.1074/jbc.M212632200 . PMID   12522145.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Pope SN, Lee IR (2005). "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". J. Steroid Biochem. Mol. Biol. 94 (1–3): 203–8. doi:10.1016/j.jsbmb.2005.01.007. PMID   15862967. S2CID   9746088.