DNAJA1

DNAJA1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LO1, 2M6Y
Identifiers
Aliases	DNAJA1 , DJ-2, DjA1, HDJ2, HSDJ, HSJ2, HSPF4, NEDD7, hDJ-2, HSJ-2, DnaJ heat shock protein family (Hsp40) member A1
External IDs	OMIM: 602837 MGI: 1270129 HomoloGene: 55588 GeneCards: DNAJA1
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9p21.1 Start 33,025,273 bp [1] End 33,039,907 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A5 Start 40,722,150 bp [2] End 40,737,149 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte bronchial epithelial cell ganglionic eminence amniotic fluid secondary oocyte stromal cell of endometrium lower lobe of lung superior vestibular nucleus prefrontal cortex parietal pleura Top expressed in morula facial motor nucleus ganglionic eminence anterior horn of spinal cord Region I of hippocampus proper neural tube trigeminal ganglion visual cortex cingulate gyrus superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chaperone binding heat shock protein binding unfolded protein binding C3HC4-type RING finger domain binding metal ion binding low-density lipoprotein particle receptor binding Hsp70 protein binding protein binding G protein-coupled receptor binding ATP binding ubiquitin protein ligase binding Tat protein binding ATPase activator activity Cellular component cytoplasm membrane intracellular membrane-bounded organelle ubiquitin ligase complex mitochondrion cytoplasmic side of endoplasmic reticulum membrane endoplasmic reticulum perinuclear region of cytoplasm extracellular exosome nucleus microtubule cytoskeleton cytosol Biological process flagellated sperm motility androgen receptor signaling pathway regulation of protein transport negative regulation of apoptotic process response to heat toxin transport negative regulation of protein ubiquitination response to unfolded protein protein folding spermatogenesis positive regulation of apoptotic process protein localization to mitochondrion negative regulation of JUN kinase activity negative regulation of establishment of protein localization to mitochondrion negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway positive regulation of ATP-dependent activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3301 15502 Ensembl ENSG00000086061 ENSMUSG00000028410 UniProt P31689 P63037 RefSeq (mRNA) NM_001539 NM_001314039 NM_001164671 NM_001164672 NM_008298 RefSeq (protein) NP_001300968 NP_001530 NP_001158143 NP_001158144 NP_032324 Location (UCSC) Chr 9: 33.03 – 33.04 Mb Chr 4: 40.72 – 40.74 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene. ^{[5] [6] [7]}

Interactions

DNAJA1 has been shown to interact with PTTG1. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000086061 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028410 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chellaiah A, Davis A, Mohanakumar T (August 1993). "Cloning of a unique human homologue of the Escherichia coli DNAJ heat shock protein". Biochim Biophys Acta. 1174 (1): 111–3. doi:10.1016/0167-4781(93)90103-k. PMID   8334160.
6. Ohtsuka K, Hata M (January 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-03-28). PMC   312896 . PMID   11147971.
7. "Entrez Gene: DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1".
8. Pei L (January 1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J. Biol. Chem. 274 (5). UNITED STATES: 3151–8. doi: 10.1074/jbc.274.5.3151 . ISSN   0021-9258. PMID   9915854.

Further reading

• Oh S, Iwahori A, Kato S (1993). "Human cDNA encoding DnaJ protein homologue". Biochim. Biophys. Acta. 1174 (1): 114–6. doi:10.1016/0167-4781(93)90104-l. PMID   8334161.
• Kanazawa M, Terada K, Kato S, Mori M (1997). "HSDJ, a human homolog of DnaJ, is farnesylated and is involved in protein import into mitochondria". J. Biochem. 121 (5): 890–5. doi:10.1093/oxfordjournals.jbchem.a021670. PMID   9192730.
• Davis AR, Alevy YG, Chellaiah A, et al. (1998). "Characterization of HDJ-2, a human 40 kD heat shock protein". Int. J. Biochem. Cell Biol. 30 (11): 1203–21. doi:10.1016/S1357-2725(98)00091-0. PMID   9839446.
• Pei L (1999). "Pituitary tumor-transforming gene protein associates with ribosomal protein S10 and a novel human homologue of DnaJ in testicular cells". J. Biol. Chem. 274 (5): 3151–8. doi: 10.1074/jbc.274.5.3151 . PMID   9915854.
• Meacham GC, Lu Z, King S, et al. (1999). "The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis". EMBO J. 18 (6): 1492–505. doi:10.1093/emboj/18.6.1492. PMC   1171238 . PMID   10075921.
• Terada K, Mori M (2000). "Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70". J. Biol. Chem. 275 (32): 24728–34. doi: 10.1074/jbc.M002021200 . PMID   10816573.
• Jana NR, Tanaka M, Wang G, Nukina N (2000). "Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity". Hum. Mol. Genet. 9 (13): 2009–18. doi: 10.1093/hmg/9.13.2009 . PMID   10942430.
• Bao YP, Cook LJ, O'Donovan D, et al. (2002). "Mammalian, yeast, bacterial, and chemical chaperones reduce aggregate formation and death in a cell model of oculopharyngeal muscular dystrophy". J. Biol. Chem. 277 (14): 12263–9. doi: 10.1074/jbc.M109633200 . PMID   11796717.
• Hernández MP, Chadli A, Toft DO (2002). "HSP40 binding is the first step in the HSP90 chaperoning pathway for the progesterone receptor". J. Biol. Chem. 277 (14): 11873–81. doi: 10.1074/jbc.M111445200 . PMID   11809754.
• Imai Y, Soda M, Hatakeyama S, et al. (2002). "CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity". Mol. Cell. 10 (1): 55–67. doi: 10.1016/S1097-2765(02)00583-X . PMID   12150907.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Hanai R, Mashima K (2004). "Characterization of two isoforms of a human DnaJ homologue, HSJ2". Mol. Biol. Rep. 30 (3): 149–53. doi:10.1023/A:1024916223616. PMID   12974469. S2CID   24105834.
• Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID   14667819.
• Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID   14743216. S2CID   11683986.
• Marschang P, Brich J, Weeber EJ, et al. (2004). "Normal development and fertility of knockout mice lacking the tumor suppressor gene LRP1b suggest functional compensation by LRP1". Mol. Cell. Biol. 24 (9): 3782–93. doi:10.1128/MCB.24.9.3782-3793.2004. PMC   387731 . PMID   15082773.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Hu Y, Zhou Z, Huang X, et al. (2005). "Expression of a novel DnaJA1 alternative splicing in human testis and sperm". Int. J. Androl. 27 (6): 343–9. doi: 10.1111/j.1365-2605.2004.00492.x . PMID   15595953.