DNAJA2

DNAJA2
Identifiers
Aliases	DNAJA2 , CPR3, DJ3, DJA2, DNAJ, DNJ3, HIRIP4, PRO3015, RDJ2, DnaJ heat shock protein family (Hsp40) member A2
External IDs	OMIM: 611322 MGI: 1931882 HomoloGene: 21193 GeneCards: DNAJA2
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q11.2 Start 46,955,362 bp [1] End 46,973,674 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8|8 C3 Start 86,264,262 bp [2] End 86,281,973 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon gastrocnemius muscle endothelial cell sperm germinal epithelium prefrontal cortex retinal pigment epithelium monocyte left ventricle islet of Langerhans Top expressed in triceps brachii muscle sternocleidomastoid muscle medial ganglionic eminence temporal muscle digastric muscle urothelium abdominal wall atrioventricular valve primitive streak calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding chaperone binding protein binding ATP binding heat shock protein binding metal ion binding ATPase activator activity Cellular component extracellular exosome membrane cytosol Biological process response to heat protein folding protein refolding positive regulation of cell population proliferation positive regulation of ATP-dependent activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10294 56445 Ensembl ENSG00000069345 ENSMUSG00000031701 UniProt O60884 Q9QYJ0 RefSeq (mRNA) NM_005880 NM_019794 RefSeq (protein) NP_005871 NP_062768 Location (UCSC) Chr 16: 46.96 – 46.97 Mb Chr 8: 86.26 – 86.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene. ^{[5] [6] [7]}

The protein encoded by this gene shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of this protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding interacting proteins, HIRIPs, have been identified. HIRIP4 was isolated by virtue of its interaction with this protein; however, its exact function is not known. The sequence of HIRIP4 protein is highly homologous to the human DNJ3/CPR3, mouse Dj3 and rat Dj2 gene products. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000069345 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031701 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lorain S, Quivy JP, Monier-Gavelle F, Scamps C, Lecluse Y, Almouzni G, Lipinski M (Sep 1998). "Core histones and HIRIP3, a novel histone-binding protein, directly interact with WD repeat protein HIRA". Mol Cell Biol. 18 (9): 5546–56. doi:10.1128/MCB.18.9.5546. PMC   109139 . PMID   9710638.
6. Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2. ISSN   1466-1268. PMC   312896 . PMID   11147971.
7. "Entrez Gene: DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2".

Further reading

• Bonwaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Edwards MC, Liegeois N, Horecka J, et al. (1998). "Human CPR (cell cycle progression restoration) genes impart a Far- phenotype on yeast cells". Genetics. 147 (3): 1063–76. doi:10.1093/genetics/147.3.1063. PMC   1208234 . PMID   9383053.
• Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma". Int. J. Cancer. 83 (4): 456–64. doi:10.1002/(SICI)1097-0215(19991112)83:4<456::AID-IJC4>3.0.CO;2-5. PMID   10508479. S2CID   21839750.
• Diefenbach J, Kindl H (2000). "The membrane-bound DnaJ protein located at the cytosolic site of glyoxysomes specifically binds the cytosolic isoform 1 of Hsp70 but not other Hsp70 species". Eur. J. Biochem. 267 (3): 746–54. doi: 10.1046/j.1432-1327.2000.01053.x . PMID   10651811.
• Terada K, Mori M (2000). "Human DnaJ homologs dj2 and dj3, and bag-1 are positive cochaperones of hsc70". J. Biol. Chem. 275 (32): 24728–34. doi: 10.1074/jbc.M002021200 . PMID   10816573.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Willingham S, Outeiro TF, DeVit MJ, et al. (2003). "Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein". Science. 302 (5651): 1769–72. Bibcode:2003Sci...302.1769W. doi:10.1126/science.1090389. PMID   14657499. S2CID   43221047.
• Kho Y, Kim SC, Jiang C, et al. (2004). "A tagging-via-substrate technology for detection and proteomics of farnesylated proteins". Proc. Natl. Acad. Sci. U.S.A. 101 (34): 12479–84. Bibcode:2004PNAS..10112479K. doi: 10.1073/pnas.0403413101 . PMC   515085 . PMID   15308774.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.

External links

• DNAJA2 human gene location in the UCSC Genome Browser .
• DNAJA2 human gene details in the UCSC Genome Browser .