DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.
DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.
This gene encodes a member of the DNAJ protein family. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. This family member may also play a role in polyglutamine aggregation in specific neurons. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described. [7]
DNAJB6 has been shown to interact with keratin 18. [8] It has been also shown that the aggregation of Aβ42 (a process involved in e.g. Alzheimer's disease) is retarded by DNAJB6 in a concentration-dependent manner, extending to very low sub-stoichiometric molar ratios of chaperone to peptide. [9] Dominant mutations in DNAJB6 have also been found to cause a late-onset muscle disease termed limb-girdle muscular dystrophy type D1 (LGMDD1), which is characterized by protein aggregation and vacuolar myopathology. [10]
Keratin 18 is a type I cytokeratin. It is, together with its filament partner keratin 8, perhaps the most commonly found products of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
Human gene HSPA1B is an intron-less gene which encodes for the heat shock protein HSP70-2, a member of the Hsp70 family of proteins. The gene is located in the major histocompatibility complex, on the short arm of chromosome 6, in a cluster with two paralogous genes, HSPA1A and HSPA1L. HSPA1A and HSPA1B produce nearly identical proteins because the few differences in their DNA sequences are almost exclusively synonymous substitutions or in the three prime untranslated region, heat shock 70kDa protein 1A, from HSPA1A, and heat shock 70kDa protein 1B, from HSPA1B. A third, more modified paralog to these genes exists in the same region, HSPA1L, which shares a 90% homology with the other two.
BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.
Cell cycle checkpoint protein RAD17 is a protein that in humans is encoded by the RAD17 gene.
DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.
DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene.
DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.
DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene.
DnaJ homolog subfamily B member 11 is a protein that in humans is encoded by the DNAJB11 gene.
DnaJ homolog subfamily B member 9 is a protein that in humans is encoded by the DNAJB9 gene.
Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.
DnaJ homolog subfamily B member 2 is a protein that in humans is encoded by the DNAJB2 gene.
DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.
DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the DNAJC7 gene.
DnaJ homolog subfamily C member 10 is a protein that in humans is encoded by the DNAJC10 gene.
DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene.
DnaJ (Hsp40) homolog, subfamily C, member 13, also known as DNAJC13, is a human gene.
Chromosome transmission fidelity protein 18 homolog is a protein that in humans is encoded by the CHTF18 gene.
Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.
In molecular biology, chaperone DnaJ, also known as Hsp40, is a molecular chaperone protein. It is expressed in a wide variety of organisms from bacteria to humans.
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