DNAJB9

DNAJB9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CTR
Identifiers
Aliases	DNAJB9 , ERdj4, MDG-1, MDG1, MST049, MSTP049, DnaJ heat shock protein family (Hsp40) member B9
External IDs	OMIM: 602634; MGI: 1351618; HomoloGene: 32155; GeneCards: DNAJB9; OMA:DNAJB9 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q31.1|14q24.2-q24.3 Start 108,569,867 bp [1] End 108,574,850 bp [1]
Gene location (Mouse) Chr. Chromosome 12 (mouse) [2] Band 12|12 B2 Start 44,252,342 bp [2] End 44,257,109 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Epithelium of choroid plexus cartilage tissue body of pancreas kidney tubule beta cell germinal epithelium corpus epididymis glomerulus decidua metanephric glomerulus Top expressed in seminal vesicula islet of Langerhans gastrula olfactory epithelium decidua parotid gland ciliary body median eminence paraventricular nucleus of hypothalamus supraoptic nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function misfolded protein binding protein binding Hsp70 protein binding chaperone binding Cellular component endoplasmic reticulum lumen endoplasmic reticulum membrane extracellular exosome nucleolus endoplasmic reticulum cytoplasm Biological process IRE1-mediated unfolded protein response ubiquitin-dependent ERAD pathway immunoglobulin production response to unfolded protein B cell differentiation response to endoplasmic reticulum stress negative regulation of IRE1-mediated unfolded protein response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4189 27362 Ensembl ENSG00000128590 ENSMUSG00000014905 UniProt Q9UBS3 Q9QYI6 RefSeq (mRNA) NM_012328 NM_013760 RefSeq (protein) NP_036460 NP_038788 Location (UCSC) Chr 7: 108.57 – 108.57 Mb Chr 12: 44.25 – 44.26 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DnaJ homolog subfamily B member 9 is a protein that in humans is encoded by the DNAJB9 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000128590 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000014905 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Prols F, Liehr T, Rinke R, Rautenstrauss B (Apr 1998). "Assignment of the microvascular endothelial differentiation gene 1 (MDG1) to human chromosome band 14q24.2→q24.3 by fluorescence in situ hybridization". Cytogenet Cell Genet. 79 (1–2): 149–50. doi:10.1159/000134706. PMID   9533036.
6. Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 12 July 2025). PMC   312896 . PMID   11147971.
7. "Entrez Gene: DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9".

Further reading

• Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Pröls F, Mayer MP, Renner O, Czarnecki PG, Ast M, Gässler C, et al. (2001). "Upregulation of the cochaperone Mdg1 in endothelial cells is induced by stress and during in vitro angiogenesis". Exp. Cell Res. 269 (1): 42–53. doi:10.1006/excr.2001.5294. PMID   11525638.
• Shen Y, Meunier L, Hendershot LM (2002). "Identification and characterization of a novel endoplasmic reticulum (ER) DnaJ homologue, which stimulates ATPase activity of BiP in vitro and is induced by ER stress". J. Biol. Chem. 277 (18): 15947–56. doi: 10.1074/jbc.M112214200 . PMID   11836248.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Scherer SW, Cheung J, MacDonald JR, Osborne LR, Nakabayashi K, Herbrick JA, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC   2882961 . PMID   12690205.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Berger BJ, Müller TS, Buschmann IR, Peters K, Kirsch M, Christ B, et al. (2003). "High levels of the molecular chaperone Mdg1/ERdj4 reflect the activation state of endothelial cells". Exp. Cell Res. 290 (1): 82–92. doi:10.1016/S0014-4827(03)00316-1. PMID   14516790.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lin KT, Lu RM, Tarn WY (2004). "The WW Domain-Containing Proteins Interact with the Early Spliceosome and Participate in Pre-mRNA Splicing In Vivo". Mol. Cell. Biol. 24 (20): 9176–85. doi:10.1128/MCB.24.20.9176-9185.2004. PMC   517884 . PMID   15456888.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl: 11858/00-001M-0000-0010-8592-0 . PMID   16169070. S2CID   8235923.