DNAJB4

DNAJB4
Identifiers
Aliases	DNAJB4 , DNAJW, DjB4, HLJ1, DnaJ heat shock protein family (Hsp40) member B4
External IDs	OMIM: 611327; MGI: 1914285; HomoloGene: 100610; GeneCards: DNAJB4; OMA:DNAJB4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p31.1 Start 77,979,175 bp [1] End 78,017,964 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 H3 Start 151,884,148 bp [2] End 151,915,939 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Skeletal muscle tissue of rectus abdominis Achilles tendon Skeletal muscle tissue of biceps brachii muscle of thigh right ventricle thoracic diaphragm tail of epididymis myocardium vena cava right coronary artery Top expressed in ascending aorta aortic valve secondary oocyte zygote seminiferous tubule primary oocyte atrioventricular valve spermatid intercostal muscle tunica media of zone of aorta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function unfolded protein binding chaperone binding protein binding ATPase activator activity Cellular component cytosol membrane cytoplasm nucleoplasm plasma membrane Biological process response to unfolded protein response to heat protein folding positive regulation of ATP-dependent activity negative regulation of transcription by RNA polymerase II chaperone cofactor-dependent protein refolding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11080 67035 Ensembl ENSG00000162616 ENSMUSG00000028035 UniProt Q9UDY4 Q9D832 RefSeq (mRNA) NM_007034 NM_001317099 NM_001317100 NM_001317101 NM_001317102 NM_001317103 NM_025926 NM_027287 NM_001356363 NM_001356364 RefSeq (protein) NP_001304028 NP_001304029 NP_001304030 NP_001304031 NP_001304032 NP_008965 NP_080202 NP_081563 NP_001343292 NP_001343293 Location (UCSC) Chr 1: 77.98 – 78.02 Mb Chr 3: 151.88 – 151.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene. ^{[5] [6] [7]}

References

1. GRCh38: Ensembl release 89: ENSG00000162616 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028035 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hoe KL, Won M, Chung KS, Jang YJ, Lee SB, Kim DU, Lee JW, Yun JH, Yoo HS (Apr 1998). "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver". Biochim Biophys Acta. 1383 (1): 4–8. doi:10.1016/s0167-4838(97)00207-0. PMID   9546042.
6. Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 12 July 2025). ISSN   1466-1268. PMC   312896 . PMID   11147971.
7. "Entrez Gene: DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID   15592455. S2CID   7200157.
• Borges JC, Fischer H, Craievich AF, Ramos CH (2005). "Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures". J. Biol. Chem. 280 (14): 13671–81. doi: 10.1074/jbc.M408349200 . PMID   15661747.
• Wang CC, Tsai MF, Hong TM, et al. (2005). "The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion". Oncogene. 24 (25): 4081–93. doi: 10.1038/sj.onc.1208573 . PMID   15782117.
• Ancevska-Taneva N, Onoprishvili I, Andria ML, et al. (2006). "A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor". Brain Res. 1081 (1): 28–33. doi:10.1016/j.brainres.2006.01.125. PMID   16542645. S2CID   42100583.
• Tsai MF, Wang CC, Chang GC, et al. (2006). "A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma". J. Natl. Cancer Inst. 98 (12): 825–38. doi: 10.1093/jnci/djj229 . PMID   16788156.