DNAJB4

DNAJB4
Identifiers
Aliases	DNAJB4 , DNAJW, DjB4, HLJ1, DnaJ heat shock protein family (Hsp40) member B4
External IDs	OMIM: 611327 MGI: 1914285 HomoloGene: 100610 GeneCards: DNAJB4
Gene location (Human)
Chr.	Chromosome 1 (human)
End	78,017,964 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	151,915,939 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; right ventricle; ; thoracic diaphragm; ; myocardium; ; vena cava; ; right coronary artery; ; saphenous vein; ; gallbladder; ; ascending aorta; ; left adrenal gland;
	Top expressed in
	ascending aorta; ; aortic valve; ; secondary oocyte; ; seminiferous tubule; ; atrioventricular valve; ; spermatid; ; intercostal muscle; ; supraoptic nucleus; ; soleus muscle; ; arcuate nucleus;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	unfolded protein binding ; chaperone binding ; protein binding ; ATPase activator activity ;
Cellular component	cytosol ; membrane ; cytoplasm ; nucleoplasm ; plasma membrane ;
Biological process	response to unfolded protein ; response to heat ; protein folding ; positive regulation of ATP-dependent activity ; negative regulation of transcription by RNA polymerase II ; chaperone cofactor-dependent protein refolding ;
	Sources:Amigo / QuickGO
Orthologs
	11080
	67035
	ENSG00000162616
	ENSMUSG00000028035
	Q9UDY4
	Q9D832
NM_007034 ; NM_001317099 ; NM_001317100 ; NM_001317101 ; NM_001317102 ;
	NM_001317103
	NM_025926 ; NM_027287 ; NM_001356363 ; NM_001356364
NP_001304028 ; NP_001304029 ; NP_001304030 ; NP_001304031 ; NP_001304032 ;
	NP_008965
	NP_080202 ; NP_081563 ; NP_001343292 ; NP_001343293
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 29, 2024

DnaJ homolog subfamily B member 4 is a protein that in humans is encoded by the DNAJB4 gene.^[5]^[6]^[7]

Related Research Articles

Human gene HSPA1B is an intron-less gene which encodes for the heat shock protein HSP70-2, a member of the Hsp70 family of proteins. The gene is located in the major histocompatibility complex, on the short arm of chromosome 6, in a cluster with two paralogous genes, HSPA1A and HSPA1L. HSPA1A and HSPA1B produce nearly identical proteins because the few differences in their DNA sequences are almost exclusively synonymous substitutions or in the three prime untranslated region, heat shock 70kDa protein 1A, from HSPA1A, and heat shock 70kDa protein 1B, from HSPA1B. A third, more modified paralog to these genes exists in the same region, HSPA1L, which shares a 90% homology with the other two.

DnaJ homolog subfamily A member 3, mitochondrial, also known as Tumorous imaginal disc 1 (TID1), is a protein that in humans is encoded by the DNAJA3 gene on chromosome 16. This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to perform protein folding, degradation, and complex assembly. As a mitochondrial protein, it is involved in maintaining membrane potential and mitochondrial DNA (mtDNA) integrity, as well as cellular processes such as cell movement, growth, and death. Furthermore, it is associated with a broad range of diseases, including neurodegenerative diseases, inflammatory diseases, and cancers.

DnaJ homolog subfamily B member 1 is a protein that in humans is encoded by the DNAJB1 gene.

DnaJ homolog subfamily A member 1 is a protein that in humans is encoded by the DNAJA1 gene.

DnaJ homolog subfamily B member 6 is a protein that in humans is encoded by the DNAJB6 gene.

DnaJ homolog subfamily C member 3 is a protein that in humans is encoded by the DNAJC3 gene.

DnaJ homolog subfamily B member 11 is a protein that in humans is encoded by the DNAJB11 gene.

DnaJ homolog subfamily B member 9 is a protein that in humans is encoded by the DNAJB9 gene.

DnaJ homolog subfamily B member 2 is a protein that in humans is encoded by the DNAJB2 gene.

DnaJ homolog subfamily A member 2 is a protein that in humans is encoded by the DNAJA2 gene.

DnaJ homolog subfamily C member 7 is a protein that in humans is encoded by the DNAJC7 gene.

Heat shock protein beta-6 (HSPB6) is a protein that in humans is encoded by the HSPB6 gene.

DnaJ homolog subfamily C member 10 is a protein that in humans is encoded by the DNAJC10 gene.

MAGUK p55 subfamily member 2 is a protein that in humans is encoded by the MPP2 gene.

DnaJ homolog subfamily C member 14 is a protein that in humans is encoded by the DNAJC14 gene.

DnaJ (Hsp40) homolog, subfamily C, member 13, also known as DNAJC13, is a human gene.

DnaJ homolog subfamily C member 28 is a protein that in humans is encoded by the DNAJC28 gene. It's a member of chaperone DnaJ family. The family is also known as Hsp40.

DnaJ homolog subfamily C member 1 is a protein that in humans is encoded by the DNAJC1 gene.

Putative tyrosine-protein phosphatase auxilin is an enzyme that in humans is encoded by the DNAJC6 gene.

DnaJ homolog subfamily C member 30 (DNAJC30), also known as Williams Beuren syndrome chromosome region 18 protein (WBSCR18), is a protein that in humans is encoded by the DNAJC30 gene. This intronless gene encodes a member of the DNAJ molecular chaperone homology domain-containing protein family. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000162616 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028035 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hoe KL, Won M, Chung KS, Jang YJ, Lee SB, Kim DU, Lee JW, Yun JH, Yoo HS (Apr 1998). "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver". Biochim Biophys Acta. 1383 (1): 4–8. doi:10.1016/s0167-4838(97)00207-0. PMID 9546042.
↑ Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-03-28). ISSN 1466-1268. PMC 312896 . PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of March 2024 (link)
↑ "Entrez Gene: DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4".

Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Rush J, Moritz A, Lee KA, et al. (2005). "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells". Nat. Biotechnol. 23 (1): 94–101. doi:10.1038/nbt1046. PMID 15592455. S2CID 7200157.
Borges JC, Fischer H, Craievich AF, Ramos CH (2005). "Low resolution structural study of two human HSP40 chaperones in solution. DJA1 from subfamily A and DJB4 from subfamily B have different quaternary structures". J. Biol. Chem. 280 (14): 13671–81. doi: 10.1074/jbc.M408349200 . PMID 15661747.
Wang CC, Tsai MF, Hong TM, et al. (2005). "The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion". Oncogene. 24 (25): 4081–93. doi: 10.1038/sj.onc.1208573 . PMID 15782117.
Ancevska-Taneva N, Onoprishvili I, Andria ML, et al. (2006). "A member of the heat shock protein 40 family, hlj1, binds to the carboxyl tail of the human mu opioid receptor". Brain Res. 1081 (1): 28–33. doi:10.1016/j.brainres.2006.01.125. PMID 16542645. S2CID 42100583.
Tsai MF, Wang CC, Chang GC, et al. (2006). "A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma". J. Natl. Cancer Inst. 98 (12): 825–38. doi: 10.1093/jnci/djj229 . PMID 16788156.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000162616 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028035 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9546042-5] Hoe KL, Won M, Chung KS, Jang YJ, Lee SB, Kim DU, Lee JW, Yun JH, Yoo HS (Apr 1998). "Isolation of a new member of DnaJ-like heat shock protein 40 (Hsp40) from human liver". Biochim Biophys Acta. 1383 (1): 4–8. doi:10.1016/s0167-4838(97)00207-0. PMID 9546042.

[pmid11147971-6] Ohtsuka K, Hata M (Jan 2001). "Mammalian HSP40/DNAJ homologs: cloning of novel cDNAs and a proposal for their classification and nomenclature". Cell Stress & Chaperones. 5 (2): 98–112. doi:10.1379/1466-1268(2000)005<0098:mhdhco>2.0.co;2 (inactive 2024-03-28). ISSN 1466-1268. PMC 312896 . PMID 11147971.{{cite journal}}: CS1 maint: DOI inactive as of March 2024 (link)

[entrez-7] "Entrez Gene: DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4".

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DNAJB4

Related Research Articles

References

Further reading