UBE2J1

UBE2J1
Identifiers
Aliases	UBE2J1 , HSPC153, HSPC205, HSU93243, NCUBE-1, NCUBE1, UBC6, Ubc6p, CGI-76, UBC6E, ubiquitin conjugating enzyme E2 J1
External IDs	OMIM: 616175 MGI: 1926245 HomoloGene: 41090 GeneCards: UBE2J1
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q15 Start 89,326,625 bp [1] End 89,352,722 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 A5 Start 33,031,416 bp [2] End 33,052,363 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm monocyte bone marrow cells parotid gland rectum amniotic fluid thymus appendix lymph node islet of Langerhans Top expressed in seminiferous tubule lacrimal gland ectoderm otic placode saccule facial motor nucleus anterior horn of spinal cord spermatid medial vestibular nucleus retinal pigment epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ATP binding ubiquitin protein ligase binding ubiquitin protein ligase activity ubiquitin conjugating enzyme activity Cellular component cytoplasm membrane integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum Biological process protein N-linked glycosylation via asparagine protein ubiquitination ubiquitin-dependent ERAD pathway spermatid development negative regulation of retrograde protein transport, ER to cytosol Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51465 56228 Ensembl ENSG00000198833 ENSMUSG00000028277 UniProt Q9Y385 Q9JJZ4 RefSeq (mRNA) NM_016021 NM_019586 NM_001355494 RefSeq (protein) NP_057105 NP_062532 NP_001342423 Location (UCSC) Chr 6: 89.33 – 89.35 Mb Chr 4: 33.03 – 33.05 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene. ^{[5] [6]}

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s.

This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000198833 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028277 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lester D, Farquharson C, Russell G, Houston B (Apr 2000). "Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6". Biochem Biophys Res Commun. 269 (2): 474–80. doi:10.1006/bbrc.2000.2302. PMID   10708578.
6. "Entrez Gene: UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Lai CH, Chou CY, Ch'ang LY, et al. (2000). "Identification of Novel Human Genes Evolutionarily Conserved in Caenorhabditis elegans by Comparative Proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC   310876 . PMID   10810093.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and Functional Analysis of cDNAs with Open Reading Frames for 300 Previously Undefined Genes Expressed in CD34+ Hematopoietic Stem/Progenitor Cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
• Lenk U, Yu H, Walter J, et al. (2002). "A role for mammalian Ubc6 homologues in ER-associated protein degradation". J. Cell Sci. 115 (Pt 14): 3007–14. doi:10.1242/jcs.115.14.3007. PMID   12082160.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wu CJ, Conze DB, Li X, et al. (2005). "TNF-α induced c-IAP1/TRAF2 complex translocation to a Ubc6-containing compartment and TRAF2 ubiquitination". EMBO J. 24 (10): 1886–98. doi:10.1038/sj.emboj.7600649. PMC   1142588 . PMID   15861135.
• Oh RS, Bai X, Rommens JM (2006). "Human homologs of Ubc6p ubiquitin-conjugating enzyme and phosphorylation of HsUbc6e in response to endoplasmic reticulum stress". J. Biol. Chem. 281 (30): 21480–90. doi: 10.1074/jbc.M601843200 . PMID   16720581.