Phenindione

Phenindione

Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy category	AU:D Passes into breast milk
Routes of administration	Oral
ATC code	B01AA02 ( WHO )
Pharmacokinetic data
Protein binding	88%
Elimination half-life	5 to 10 hours
Identifiers
IUPAC name 2-phenyl-1H-indene-1,3(2H)-dione
CAS Number	83-12-5  Y
PubChem CID	4760
IUPHAR/BPS	6838
DrugBank	DB00498  Y
ChemSpider	4596  Y
UNII	5M7Y6274ZE
KEGG	D08354  Y
ChEBI	CHEBI:8066  Y
ChEMBL	ChEMBL711  Y
CompTox Dashboard (EPA)	DTXSID5023453
ECHA InfoCard	100.001.323
Chemical and physical data
Formula	C15H10O2
Molar mass	222.243 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C2c1ccccc1C(=O)C2c3ccccc3
InChI InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H Y Key:NFBAXHOPROOJAW-UHFFFAOYSA-N Y
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Phenindione is an anticoagulant which functions as a Vitamin K antagonist.

Phenindione was introduced in the early 1950s. It acts similar to warfarin, but it has been associated with hypersensitivity reactions, so it is rarely used and warfarin is preferred. ^{[1] [2]}

References

1. Naisbitt DJ, Farrell J, Chamberlain PJ, Hopkins JE, Berry NG, Pirmohamed M, Park BK (June 2005). "Characterization of the T-cell response in a patient with phenindione hypersensitivity". The Journal of Pharmacology and Experimental Therapeutics. 313 (3): 1058–65. doi:10.1124/jpet.105.083758. PMID   15743920. S2CID   17052792.
2. Sweetman SC, ed. (2009). Martindale: The Complete Drug Reference (36th ed.). London: Pharmaceutical Press. "Phenindione", p. 1369.

External links

• Diseases Database (DDB): 30536