Bleomycin hydrolase

BLMH
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1CB5, 2CB5
Identifiers
Aliases	BLMH , BH, BMH, bleomycin hydrolase
External IDs	OMIM: 602403; MGI: 1345186; HomoloGene: 330; GeneCards: BLMH; OMA:BLMH - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q11.2 Start 30,248,203 bp [1] End 30,292,056 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 B5 Start 76,815,635 bp [2] End 76,878,205 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of arm skin of leg skin of abdomen skin of thigh epithelium of colon body of pancreas Descending thoracic aorta mucosa of esophagus stromal cell of endometrium body of uterus Top expressed in fossa condyle primitive streak hair follicle renal corpuscle internal carotid artery esophagus vas deferens external carotid artery skin of abdomen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity hydrolase activity carboxypeptidase activity cysteine-type endopeptidase activity protein binding cysteine-type peptidase activity aminopeptidase activity identical protein binding Cellular component extracellular exosome cytosol nucleus cytoplasm Biological process protein polyubiquitination proteolysis response to toxic substance homocysteine catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 642 104184 Ensembl ENSG00000108578 ENSMUSG00000020840 UniProt Q13867 Q8R016 RefSeq (mRNA) NM_000386 NM_178645 RefSeq (protein) NP_000377 NP_848760 Location (UCSC) Chr 17: 30.25 – 30.29 Mb Chr 11: 76.82 – 76.88 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Bleomycin hydrolase is an enzyme that in humans is encoded by the BLMH gene. ^{[5] [6] [7]}

Bleomycin hydrolase (BMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. Its biological function is hydrolysis of the reactive electrophile homocysteine thiolactone. ^[8] Another of its activities is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The protein contains the signature active site residues of the cysteine protease papain superfamily. ^[7]

Interactions

BLMH has been shown to interact with RPL29, ^[9] RPL11, ^[9] UBE2I ^[10] and Amyloid precursor protein. ^[11]

References

1. GRCh38: Ensembl release 89: ENSG00000108578 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020840 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ferrando AA, Pendas AM, Llano E, Velasco G, Lidereau R, Lopez-Otin C (January 1998). "Gene characterization, promoter analysis, and chromosomal localization of human bleomycin hydrolase". J Biol Chem. 272 (52): 33298–304. doi: 10.1074/jbc.272.52.33298 . PMID   9407121.
6. Montoya SE, Ferrell RE, Lazo JS (October 1997). "Genomic structure and genetic mapping of the human neutral cysteine protease bleomycin hydrolase". Cancer Res. 57 (19): 4191–5. PMID   9331073.
7. "Entrez Gene: BLMH bleomycin hydrolase".
8. Jarosław Zimny, Marta Sikora, Andrzej Guranowski, Hieronim Jakubowski (2006). "Protective Mechanisms against Homocysteine Toxicity". The Journal of Biological Chemistry. 281 (32): 22485–22492. Bibcode:2006JBiCh.28122485Z. doi: 10.1074/jbc.M603656200 . PMID   16769724.
9. Koldamova RP, Lefterov I M, DiSabella M T, Almonte C, Watkins S C, Lazo J S (June 1999). "Human bleomycin hydrolase binds ribosomal proteins". Biochemistry. 38 (22). UNITED STATES: 7111–7. doi:10.1021/bi990135l. ISSN   0006-2960. PMID   10353821.
10. Koldamova RP, Lefterov I M, DiSabella M T, Lazo J S (December 1998). "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9". Mol. Pharmacol. 54 (6). UNITED STATES: 954–61. doi:10.1124/mol.54.6.954. ISSN   0026-895X. PMID   9855622. S2CID   2272861.
11. Lefterov IM, Koldamova R P, Lazo J S (September 2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein". FASEB J. 14 (12). UNITED STATES: 1837–47. doi: 10.1096/fj.99-0938com . ISSN   0892-6638. PMID   10973933. S2CID   44302063.

External links

• Human BLMH genome location and BLMH gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q13867 (Bleomycin hydrolase) at the PDBe-KB .

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Ferrando AA, Velasco G, Campo E, Lopez-Otin C (1996). "Cloning and expression analysis of human bleomycin hydrolase, a cysteine proteinase involved in chemotherapy resistance". Cancer Res. 56 (8): 1746–50. PMID   8620487.
• Brömme D, Rossi AB, Smeekens SP, et al. (1996). "Human bleomycin hydrolase: molecular cloning, sequencing, functional expression, and enzymatic characterization". Biochemistry. 35 (21): 6706–14. doi:10.1021/bi960092y. PMID   8639621.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Koldamova RP, Lefterov IM, Gadjeva VG, Lazo JS (1998). "Essential binding and functional domains of human bleomycin hydrolase". Biochemistry. 37 (8): 2282–90. doi:10.1021/bi9722204. PMID   9485374.
• Montoya SE, Aston CE, DeKosky ST, et al. (1998). "Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease". Nat. Genet. 18 (3): 211–2. doi:10.1038/ng0398-211. PMID   9500538. S2CID   2940414.
• Zheng W, Johnston SA, Joshua-Tor L (1998). "The unusual active site of Gal6/bleomycin hydrolase can act as a carboxypeptidase, aminopeptidase, and peptide ligase". Cell. 93 (1): 103–9. doi: 10.1016/S0092-8674(00)81150-2 . PMID   9546396.
• Koldamova RP, Lefterov IM, DiSabella MT, Lazo JS (1999). "An evolutionarily conserved cysteine protease, human bleomycin hydrolase, binds to the human homologue of ubiquitin-conjugating enzyme 9". Mol. Pharmacol. 54 (6): 954–61. doi:10.1124/mol.54.6.954. PMID   9855622. S2CID   2272861.
• Takeda A, Nonaka M, Ishikawa A, Higuchi D (1999). "Immunohistochemical localization of the neutral cysteine protease bleomycin hydrolase in human skin". Arch. Dermatol. Res. 291 (4): 238–40. doi:10.1007/s004030050400. PMID   10335922. S2CID   10799259.
• Koldamova RP, Lefterov IM, DiSabella MT, et al. (1999). "Human bleomycin hydrolase binds ribosomal proteins". Biochemistry. 38 (22): 7111–7. doi:10.1021/bi990135l. PMID   10353821.
• O'Farrell PA, Gonzalez F, Zheng W, et al. (1999). "Crystal structure of human bleomycin hydrolase, a self-compartmentalizing cysteine protease". Structure. 7 (6): 619–27. doi: 10.1016/S0969-2126(99)80083-5 . PMID   10404591.
• Malherbe P, Faull RL, Richards JG (2000). "Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains". Neurosci. Lett. 281 (1): 37–40. doi:10.1016/S0304-3940(00)00802-8. PMID   10686410. S2CID   41562274.
• Lefterov IM, Koldamova RP, Lazo JS (2000). "Human bleomycin hydrolase regulates the secretion of amyloid precursor protein". FASEB J. 14 (12): 1837–47. doi: 10.1096/fj.99-0938com . PMID   10973933. S2CID   44302063.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Nivet-Antoine V, Coulhon MP, Le Denmat C, et al. (2003). "[Apolipoprotein E and bleomycin hydrolase. Polymorphisms: association with neurodegenerative diseases]". Ann. Biol. Clin. (Paris). 61 (1): 61–7. PMID   12604387.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.