Curling's ulcer

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Curling's ulcer
Other namesCurling ulcer
Specialty General surgery, Gastroenterology

Curling's ulcer is an acute gastric erosion resulting as a complication from severe burns when reduced plasma volume leads to ischemia and cell necrosis (sloughing) of the gastric mucosa. The condition was first described in 1823 and named after Thomas Blizard Curling, who observed ten such patients in 1842. [1] [2]

Contents

These stress ulcers (actually shallow multiple erosions) were once a common complication of serious burns, presenting in over 10% of cases, [1] and especially common in child burn victims. [3] They result in perforation and hemorrhage more often than other forms of intestinal ulceration [4] and had correspondingly high mortality rates (at least 80%). [1] [5]

Treatment

While emergency surgery was once the only treatment, combination therapies including enteral feeding with powerful antacids such as H2-receptor antagonists or, more recently, proton pump inhibitors such as omeprazole have made Curling's ulcer a rare complication. [6]

See also

Related Research Articles

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References

  1. 1 2 3 Pruitt, Basil A. Jr.; F.D. Foley & John A. Moncrief (October 1970). "Curling's ulcer: a clinical-pathology study of 323 cases". Annals of Surgery. 172 (4): 523–39. doi:10.1097/00000658-197010000-00001. PMC   1397279 . PMID   5311720.
  2. Curling, T. B. (1842). "On acute ulceration of the duodenum, in cases of burn". Medico-Chirurgical Transactions. 25: 260–281.
  3. Bruck, H.M.; Basil A. Pruitt Jr. (June 1972). "Curling's ulcer in children: a 12-year review of 63 cases". Journal of Trauma. 12 (6): 490–6. doi:10.1097/00005373-197206000-00006. PMID   5033495.
  4. Lev R.; Klein, Martin S.; Ennis, Frank; Sherlock, Paul; Winawer, Sidney J. (December 1973). "Letter: Stress erosions". Am J Dig Dis. 18 (12): 1099–100. doi:10.1007/BF01076530. PMID   4543410.
  5. Pedro-Pons, Agustín (1968). Patología y Clínica Médicas (in Spanish). Vol. 6 (3rd ed.). Barcelona: Salvat. p. 1198. ISBN   84-345-1106-1.
  6. Moran KT, O'Reilly T, Munster AM (October 1987). "A combined regimen for the prophylaxis of Curling's ulcer". Am Surg. 53 (10): 575–6. PMID   2890321.