DTP-HepB vaccine

DTP-HepB
Combination of
DTP vaccine	Vaccine
Hepatitis B vaccine	Vaccine
Clinical data
Trade names	Tritanrix-HepB
AHFS/Drugs.com	UK Drug Information
Routes of; administration	Intramuscular injection
ATC code	J07CA05 ( WHO );
Identifiers
CAS Number	1012056-47-1 ;

Last updated October 01, 2025

DTP-HepB vaccine is a combination vaccine whose generic name is diphtheria and tetanus toxoids and whole-cell pertussis and hepatitis B (recombinant) vaccine (adsorbed) or DTP-Hep B. It protects against the infectious diseases diphtheria, tetanus, pertussis, and hepatitis B.^[1]

A branded formulation, Tritanrix-HepB manufactured by GlaxoSmithKline, was granted marketing approval in the EU in 1996. Marketing approval lapsed in 2014.^[2]

A review conducted in 2012 concluded that there was insufficient evidence to determine differences in safety and efficacy between DTP-HepB vaccine and Hib vaccine administered separately and pentavalent DTP-HepB-Hib vaccine.^[3]

References

↑ World Health Organization; World Health Organization Department of Immunization, Vaccines and Biologicals (2004). Immunization in Practice: A Practical Guide for Health Staff. World Health Organization. p. 18. ISBN 978-92-4-154651-5 . Retrieved 15 July 2018.
↑ "Tritanrix HepB". European Medicines Agency. Archived from the original on 15 July 2018. Retrieved 14 July 2018.
↑ Bar-On ES, Goldberg E, Hellmann S, Leibovici L (April 2012). "Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB)". The Cochrane Database of Systematic Reviews. 2012 (4) CD005530. doi:10.1002/14651858.CD005530.pub3. PMC 11440342 . PMID 22513932.

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[1] World Health Organization; World Health Organization Department of Immunization, Vaccines and Biologicals (2004). Immunization in Practice: A Practical Guide for Health Staff. World Health Organization. p. 18. ISBN 978-92-4-154651-5 . Retrieved 15 July 2018.

[2] "Tritanrix HepB". European Medicines Agency. Archived from the original on 15 July 2018. Retrieved 14 July 2018.

[Bar-OnGoldberg2012-3] Bar-On ES, Goldberg E, Hellmann S, Leibovici L (April 2012). "Combined DTP-HBV-HIB vaccine versus separately administered DTP-HBV and HIB vaccines for primary prevention of diphtheria, tetanus, pertussis, hepatitis B and Haemophilus influenzae B (HIB)". The Cochrane Database of Systematic Reviews. 2012 (4) CD005530. doi:10.1002/14651858.CD005530.pub3. PMC 11440342 . PMID 22513932.

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