|  | 
| By-election | Date | Former incumbent | Party | Winner | Party | Cause | 
|---|
| Tipperary | 16 March 1857 | James Sadleir |  | Independent Irish | Daniel O'Donoghue |  | Independent Irish | Expulsion (Absconded to avoid charges for fraud) | 
| County Londonderry | 9 March 1857 | Thomas Bateson |  | Conservative | James Johnston Clark |  | Conservative | Resignation | 
| East Sussex | 7 March 1857 | Charles Frewen |  | Conservative | Viscount Pevensey |  | Conservative | Resignation (intended to contest North Leicestershire) | 
| Glasgow | 6 March 1857 | John MacGregor |  | Whig | Walter Buchanan |  | Whig | Resignation | 
| North Leicestershire | 2 March 1857 [16 1] | Marquess of Granby |  | Conservative | Lord John Manners |  | Conservative | Succession to a peerage | 
| Colchester | 24 February 1857 [16 1] | Lord John Manners |  | Conservative | John Gurdon Rebow |  | Whig | Resignation in order to contest North Leicestershire | 
| County Limerick | 17 February 1857 [16 1] | William Monsell |  | Whig | William Monsell |  | Whig | President of the Board of Health  [16 2] | 
| Clonmel | 17 February 1857 | John O'Connell |  | Whig | John Bagwell |  | Whig | Resignation (Clerk of the Crown and Hanaper in Ireland) | 
| West Kent | 16 February 1857 [16 1] | Sir Edmund Filmer |  | Conservative | Charles Wykeham Martin |  | Whig | Death | 
| Hereford | 14 February 1857 | Sir Robert Price |  | Whig | George Clive |  | Whig | Resignation | 
| Bandon | 14 February 1857 | Viscount Bernard |  | Conservative | William Smyth Bernard |  | Conservative | Succession to an Irish peerage | 
| Dumfriesshire | 12 February 1857 [16 1] | Viscount Drumlanrig |  | Conservative | John Hope-Johnstone |  | Conservative | Succession to a Scottish peerage | 
| Downpatrick | 12 February 1857 | Charles Hardinge |  | Conservative | Richard Ker |  | Conservative | Succession to a peerage | 
| Buteshire | 12 February 1857 [16 1] | James Stuart-Wortley |  | Peelite | James Stuart-Wortley |  | Peelite | Solicitor General for England and Wales  [16 2] | 
| Southampton | 11 February 1857 | Alexander Cockburn |  | Whig | Thomas Matthias Weguelin |  | Whig | Resignation (Chief Justice of the Common Pleas) | 
| Newport (I.O.W.) | 11 February 1857 | William Biggs |  | Whig | Robert Kennard |  | Conservative | Resignation | 
| Kingston upon Hull | 11 February 1857 [16 1] | William Henry Watson |  | Whig | James Clay |  | Whig | Resignation (Baron of the Court of Exchequer) | 
| Hertford | 9 February 1857 [16 1] | William Cowper |  | Whig | William Cowper |  | Whig | Vice-President of the Committee of the Council on Education  [16 2] | 
| Greenwich | 9 February 1857 | Peter Rolt |  | Conservative | William Codrington |  | Whig | Resignation | 
| Aylesbury | 9 February 1857 [16 1] | Richard Bethell |  | Whig | Richard Bethell |  | Whig | Attorney General for England and Wales  [16 2] | 
| Salford | 2 February 1857 [16 1] | Joseph Brotherton |  | Whig | Edward Ryley Langworthy |  | Ind. Whig [1] | Death | 
| Lanarkshire | 9 January 1857 [16 1] | William Lockhart |  | Conservative | Alexander Baillie-Cochrane |  | Conservative | Death | 
| East Suffolk | 26 December 1856 [16 1] | Sir Edward Gooch |  | Conservative | The Lord Henniker |  | Conservative | Death | 
| Kerry | 9 August 1856 [16 1] | Viscount Castlerosse |  | Whig | Viscount Castlerosse |  | Whig | Comptroller of the Household  [16 2] | 
| Nottingham | 30 July 1856 [16 1] | Edward Strutt |  | Whig | Charles Paget |  | Whig | Resignation and elevation to the peerage | 
| Dorset | 26 July 1856 [16 1] | George Bankes |  | Conservative | Henry Sturt |  | Conservative | Death | 
| Frome | 23 July 1856 | Viscount Dungarvan |  | Whig | William George Boyle |  | Whig | Succession to a peerage | 
| Dorchester | 22 July 1856 [16 1] | Henry Sturt |  | Conservative | Charles Napier Sturt |  | Conservative | Resignation in order to contest Dorset | 
| Calne | 9 July 1856 [16 1] | Earl of Shelburne |  | Whig | Sir William Fenwick Williams |  | Whig | Resignation and elevation to the House of Lords through a Writ of acceleration | 
| Leicester | 18 June 1856 [16 1] | Richard Gardner |  | Whig | John Biggs |  | Whig | Death | 
| Lichfield | 30 May 1856 [16 1] | The Lord Waterpark |  | Whig | Viscount Sandon |  | Ind. Whig [2]  [3] | Resignation | 
| Longford | 13 May 1856 [16 1] | Richard Maxwell Fox |  | Whig | Henry George Hughes |  | Whig | Death | 
| Cheltenham | 8 May 1856 | Grenville Berkeley |  | Whig | Francis Berkeley |  | Whig | Resignation | 
| Athlone | 14 April 1856 | William Keogh |  | Whig | Henry Handcock |  | Conservative | Resignation (Judge of the Court of Common Pleas) | 
| Chippenham | 9 April 1856 [16 1] | Joseph Neeld |  | Conservative | Robert Parry Nisbet |  | Conservative | Death | 
| Ennis | 8 April 1856 [16 1] | John David FitzGerald |  | Whig | John David FitzGerald |  | Whig | Attorney-General for Ireland  [16 2] | 
| Boston | 7 March 1856 | Gilbert Heathcote |  | Whig | Herbert Ingram |  | Whig | Resignation in order to contest Rutlandshire | 
| Rutlandshire | 4 March 1856 [16 1] | Sir Gilbert Heathcote |  | Whig | Gilbert Heathcote |  | Whig | Resignation and elevation to the peerage | 
| Leominster | 19 February 1856 | George Arkwright |  | Conservative | Gathorne Hardy |  | Conservative | Death | 
| New Ross | 18 February 1856 | Charles Gavan Duffy |  | Independent Irish | Charles Tottenham |  | Conservative | Resignation | 
| Cambridge University | 11 February 1856 | Henry Goulburn |  | Conservative | Spencer Horatio Walpole |  | Conservative | Death | 
| Wigtownshire | 9 February 1856 [16 1] | Viscount Dalrymple |  | Whig | Sir Andrew Agnew |  | Whig | Resignation | 
| Edinburgh | 9 February 1856 | Thomas Babington Macaulay |  | Whig | Adam Black |  | Whig | Resignation | 
| Sligo Borough | 8 February 1856 | John Sadleir |  | Whig | John Arthur Wynne |  | Conservative | Death | 
| Rochester | 8 February 1856 | Francis Child Villiers |  | Conservative | Philip Wykeham Martin |  | Whig | Resignation | 
| Tamworth | 7 February 1856 [16 1] | John Townshend |  | Whig | Viscount Raynham |  | Whig | Succession to a peerage | 
| Midhurst | 7 February 1856 [16 1] | Spencer Horatio Walpole |  | Conservative | Samuel Warren |  | Conservative | Resignation in order to contest Cambridge University | 
| Leeds | 6 February 1856 [16 1] | Matthew Talbot Baines |  | Whig | Matthew Talbot Baines |  | Whig | Chancellor of the Duchy of Lancaster  [16 2] | 
| Taunton | 5 February 1856 [16 1] | Henry Labouchere |  | Whig | Henry Labouchere |  | Whig | Secretary of State for the Colonies  [16 2] | 
| Newcastle upon Tyne | 5 February 1856 [16 1] | John Fenwick Burgoyne Blackett |  | Whig | George Ridley |  | Whig | Resignation | 
| Lincoln | 16 January 1856 [16 1] | Charles Delaet Waldo Sibthorp |  | Conservative | Gervaise Tottenham Waldo Sibthorp |  | Conservative | Death | 
| Meath | 17 December 1855 | Frederick Lucas |  | Independent Irish | Edward McEvoy |  | Independent Irish | Death | 
| Armagh City | 6 December 1855 | Ross Stephenson Moore |  | Conservative | Joshua Bond |  | Conservative | Death | 
| Wells | 21 November 1855 | Robert Charles Tudway |  | Conservative | Hedworth Hylton Jolliffe |  | Conservative | Death | 
| Southwark | 20 November 1855 [16 1] | Sir William Molesworth |  | Radical | Charles Napier |  | Whig | Death | 
| Totnes | 5 November 1855 [16 1] | Lord Seymour |  | Whig | Earl of Gifford |  | Whig | Succession to a peerage | 
| Huntingdonshire | 23 October 1855 [16 1] | Viscount Mandeville |  | Conservative | James Rust |  | Conservative | Succession to a peerage | 
| Kilmarnock Burghs | 16 August 1855 [16 1] | Edward Pleydell-Bouverie |  | Whig | Edward Pleydell-Bouverie |  | Whig | President of the Poor Law Board  [16 2] | 
| Kidderminster | 14 August 1855 [16 1] | Robert Lowe |  | Whig | Robert Lowe |  | Whig | Vice-President of the Board of Trade and Paymaster General  [16 2] | 
| Hertford | 14 August 1855 [16 1] | William Cowper |  | Whig | William Cowper |  | Whig | President of the Board of Health  [16 2] | 
| Marylebone | 28 July 1855 [16 1] | Sir Benjamin Hall |  | Peelite | Sir Benjamin Hall |  | Peelite | First Commissioner of Works  [16 2] | 
| Southwark | 27 July 1855 [16 1] | Sir William Molesworth |  | Radical | Sir William Molesworth |  | Radical | Secretary of State for the Colonies  [16 2] | 
| East Norfolk | 17 July 1855 [16 1] | Edmond Wodehouse |  | Conservative | Sir Henry Stracey |  | Conservative | Resignation | 
| Cheltenham | 14 July 1855 | Craven Berkeley |  | Whig | Grenville Berkeley |  | Whig | Death | 
| Evesham | 11 July 1855 [16 1] | Grenville Berkeley |  | Whig | Edward Holland |  | Whig | Resignation in order to contest Cheltenham | 
| Bath | 5 June 1855 | Thomas Phinn |  | Whig | William Tite |  | Whig | Resignation | 
| Renfrewshire | 14 May 1855 [16 1] | William Mure |  | Conservative | Sir Michael Shaw-Stewart |  | Conservative | Resignation | 
| County Cork | 23 April 1855 | Edmond Roach |  | Whig | Rickard Deasy |  | Whig | Resignation and elevation to the Irish peerage | 
| Cavan | 13 April 1855 | Sir John Young |  | Peelite | Robert Burrowes |  | Conservative | Resignation (Lord High Commissioner of the Ionian Islands) | 
| Kilmarnock Burghs | 7 April 1855 [16 1] | Edward Pleydell-Bouverie |  | Whig | Edward Pleydell-Bouverie |  | Whig | Vice-President of the Board of Trade and Paymaster General  [16 2] | 
| Lewes | 5 April 1855 [16 1] | Henry Brand |  | Whig | Henry Brand |  | Whig | Junior Lord of the Treasury  [16 2] | 
| Gloucester | 31 March 1855 [16 1] | William Philip Price |  | Whig | William Philip Price |  | Whig | Seeks re-election after his firm was granted a contract to supply huts to the army in the Crimea | 
| Liverpool | 29 March 1855 | Henry Thomas Liddell |  | Conservative | Joseph Christopher Ewart |  | Whig | Succession to a peerage | 
| Wilton | 28 March 1855 [16 1] | Charles A'Court |  | Whig | Edmund Antrobus |  | Whig | Resignation (Special Commissioner of Property and Income Tax) | 
| Tamworth | 14 March 1855 [16 1] | Sir Robert Peel |  | Peelite | Sir Robert Peel |  | Peelite | Civil Lord of the Admiralty  [16 2] | 
| Portsmouth | 14 March 1855 | The Viscount Monck |  | Whig | The Viscount Monck |  | Whig | Junior Lord of the Treasury  [16 2] | 
| Forfarshire | 10 March 1855 [16 1] | Viscount Duncan |  | Whig | Viscount Duncan |  | Whig | Junior Lord of the Treasury  [16 2] | 
| Barnstaple | 10 March 1855 [16 1] | John Laurie |  | Conservative | George Buck |  | Conservative | Void By-Election | 
| Montrose Burghs | 9 March 1855 | Joseph Hume |  | Whig | William Edward Baxter |  | Whig | Death | 
| Ennis | 8 March 1855 [16 1] | John David FitzGerald |  | Independent Irish | John David FitzGerald |  | Whig | Solicitor-General for Ireland  [16 2] | 
| Dudley | 8 March 1855 | John Benbow |  | Conservative | Sir Stafford Northcote |  | Conservative | Death | 
| Athlone | 7 March 1855 [16 1] | William Keogh |  | Whig | William Keogh |  | Whig | Attorney-General for Ireland  [16 2] | 
| Stroud | 6 March 1855 [16 1] | Edward Horsman |  | Whig | Edward Horsman |  | Whig | Chief Secretary for Ireland  [16 2] | 
| Stirlingshire | 5 March 1855 [16 1] | William Forbes |  | Conservative | Peter Blackburn |  | Conservative | Death | 
| Radnor Boroughs | 5 March 1855 [16 1] | George Cornewall Lewis |  | Whig | George Cornewall Lewis |  | Whig | Chancellor of the Exchequer  [16 2] | 
| Northampton | 5 March 1855 [16 1] | Robert Vernon Smith |  | Whig | Robert Vernon Smith |  | Whig | President of the Board of Control  [16 2] | 
| Halifax | 3 March 1855 [16 1] | Sir Charles Wood |  | Whig | Sir Charles Wood |  | Whig | First Lord of the Admiralty  [16 2] | 
| City of London | 3 March 1855 [16 1] | Lord John Russell |  | Whig | Lord John Russell |  | Whig | Secretary of State for the Colonies  [16 2] | 
| Swansea District | 27 February 1855 [16 1] | John Henry Vivian |  | Whig | Lewis Llewelyn Dillwyn |  | Whig | Death | 
| Cardigan Boroughs | 24 February 1855 | Pryse Loveden |  | Whig | John Lloyd Davies |  | Conservative | Death | 
| South Wiltshire | 15 February 1855 [16 1] | Sidney Herbert |  | Peelite | Sidney Herbert |  | Peelite | Secretary of State for the Colonies  [16 2] | 
| Windsor | 14 February 1855 [16 1] | Lord Charles Wellesley |  | Conservative | Samson Ricardo |  | Whig | Resignation | 
| Tiverton | 12 February 1855 [16 1] | The Viscount Palmerston |  | Whig | The Viscount Palmerston |  | Whig | Prime Minister and First Lord of the Treasury  [16 2] | 
| Radnor Boroughs | 8 February 1855 [16 1] | Sir Thomas Frankland Lewis |  | Whig | George Cornewall Lewis |  | Whig | Death | 
| Sunderland | 2 January 1855 | William Digby Seymour |  | Whig | Henry Fenwick |  | Whig | Recorder of Newcastle  [16 2] | 
| Ayrshire | 30 December 1854 | James Hunter Blair |  | Conservative | Sir James Fergusson |  | Conservative | Death | 
| Norwich | 29 December 1854 | Samuel Morton Peto |  | Whig | Samuel Bignold |  | Conservative | Resignation | 
| Fermanagh | 29 December 1854 [16 1] | Sir Arthur Brooke |  | Conservative | Henry Cole |  | Conservative | Death | 
| Antrim | 27 December 1854 [16 1] | Edward William Pakenham |  | Conservative | Thomas Henry Pakenham |  | Conservative | Death | 
| County Limerick | 26 December 1854 [16 1] | Wyndham Goold |  | Whig | Stephen de Vere |  | Whig | Death | 
| Marylebone | 20 December 1854 | Lord Dudley Stuart |  | Whig | Viscount Ebrington |  | Whig | Death | 
| East Gloucestershire | 19 December 1854 | Sir Michael Hicks Beach |  | Conservative | Robert Stayner Holford |  | Conservative | Death | 
| Abingdon | 13 December 1854 | Lord Norreys |  | Whig | Joseph Haythorne Reed |  | Whig | Succession to a peerage | 
| Bedford | 6 December 1854 | Henry Stuart |  | Conservative | William Stuart |  | Conservative | Death | 
| Coventry | 2 December 1854 [16 1] | Charles Geach |  | Whig | Joseph Paxton |  | Whig | Death | 
| Limerick City | 28 October 1854 [16 1] | Robert Potter |  | Independent Irish | James O'Brien |  | Whig | Death | 
| Frome | 24 October 1854 | Robert Edward Boyle |  | Whig | Viscount Dungarvan |  | Whig | Death | 
| Forfarshire | 11 October 1854 [16 1] | Lauderdale Maule |  | Whig | Viscount Duncan |  | Whig | Death | 
| Wigan | 3 October 1854 | Ralph Anthony Thicknesse |  | Whig | Joseph Acton |  | Whig | Death | 
| King's Lynn | 16 September 1854 [16 1] | Viscount Jocelyn |  | Conservative | John Henry Gurney |  | Whig | Death | 
| Barnstaple | 25 August 1854 | Richard Bremridge |  | Conservative | John Laurie |  | Conservative | Void election | 
| Sir William Fraser |  | Conservative | Richard Samuel Guinness |  | Conservative | Void election | 
| Aberdeenshire | 22 August 1854 [16 1] | William Gordon |  | Conservative | Lord Haddo |  | Whig | Resignation | 
| Kingston upon Hull | 18 August 1854 | Viscount Goderich |  | Whig | William Henry Watson |  | Whig | Void election | 
| James Clay |  | Whig | William Digby Seymour |  | Whig | Void election | 
| Canterbury | 18 August 1854 | Henry Plumptre Gipps |  | Conservative | Charles Manners Lushington |  | Conservative | Void election | 
| Henry Butler-Johnstone |  | Conservative | Sir William Somerville |  | Whig | Void election | 
| Cambridge | 18 August 1854 | Kenneth Macaulay |  | Conservative | Robert Adair |  | Whig | Void election | 
| John Harvey Astell |  | Conservative | Francis Mowatt |  | Whig | Void election | 
| Maldon | 17 August 1854 | Charles Du Cane |  | Conservative | George Sandford |  | Conservative | Void election | 
| Taverner John Miller |  | Conservative | John Bramley-Moore |  | Conservative | Void election | 
| Marylebone | 16 August 1854 [16 1] | Sir Benjamin Hall |  | Whig | Sir Benjamin Hall |  | Whig | President of the Board of Health  [16 2] | 
| Cockermouth | 9 August 1854 [16 1] | Henry Aglionby Aglionby |  | Whig | John Steel |  | Whig | Death | 
| Beverley | 31 July 1854 | Francis Charles Lawley |  | Whig | Arthur Hamilton-Gordon |  | Whig | Resignation | 
| Morpeth | 17 June 1854 [16 1] | Sir George Grey |  | Whig | Sir George Grey |  | Whig | Secretary of State for the Colonies  [16 2] | 
| City of London | 14 June 1854 [16 1] | Lord John Russell |  | Whig | Lord John Russell |  | Whig | Lord President of the Council  [16 2] | 
| Hertfordshire | 24 May 1854 | Thomas Plumer Halsey |  | Conservative | Abel Smith, Jnr |  | Conservative | Death | 
| Devonport | 11 May 1854 | Henry Tufnell |  | Whig | Thomas Erskine Perry |  | Whig | Resignation | 
| Hastings | 10 May 1854 [16 1] | Musgrave Brisco |  | Conservative | Frederick North |  | Whig | Resignation | 
| Lichfield | 9 May 1854 [16 1] | Viscount Anson |  | Whig | The Lord Waterpark |  | Whig | Succession to a peerage | 
| Flintshire | 8 May 1854 [16 1] | Edward Lloyd-Mostyn |  | Whig | Thomas Lloyd-Mostyn |  | Whig | Succession to a peerage | 
| Southampton | 12 April 1854 [16 1] | Alexander Cockburn |  | Whig | Alexander Cockburn |  | Whig | Recorder of Bristol  [16 2] | 
| North Durham | 1 April 1854 [16 1] | Viscount Seaham |  | Conservative | Lord Adolphus Vane-Tempest |  | Conservative | Succession to a peerage | 
| Westmorland | 31 March 1854 [16 1] | William Thompson |  | Conservative | Earl of Bective |  | Conservative | Death | 
| Tynemouth and North Shields | 30 March 1854 | Hugh Taylor |  | Conservative | William Schaw Lindsay |  | Whig | Void election | 
| Liskeard | 29 March 1854 | Richard Budden Crowder |  | Whig | Ralph William Grey |  | Whig | Resignation (Judge of the Court of Common Pleas) | 
| Louth | 27 February 1854 | Chichester Fortescue |  | Whig | Chichester Fortescue |  | Whig | Junior Lord of the Treasury  [16 2] | 
| Cardiganshire | 22 February 1854 [16 1] | William Edward Powell |  | Conservative | The Earl of Lisburne |  | Conservative | Resignation | 
| South Devon | 14 February 1854 [16 1] | Sir Ralph Lopes |  | Conservative | Lawrence Palk |  | Conservative | Death | 
| West Sussex | 13 February 1854 [16 1] | Richard Prime |  | Conservative | Henry Wyndham |  | Conservative | Resignation | 
| South Staffordshire | 8 February 1854 | Viscount Lewisham |  | Conservative | Lord Paget |  | Whig | Succession to a peerage | 
| South Shropshire | 8 February 1854 [16 1] | Robert Clive |  | Conservative | Robert Windsor-Clive |  | Conservative | Death | 
| Oxford University | 7 February 1854 [16 1] | Robert Inglis |  | Conservative | Sir William Heathcote, |  | Conservative | Resignation | 
| Ludlow | 7 February 1854 [16 1] | Robert Windsor-Clive |  | Conservative | Percy Egerton Herbert |  | Conservative | Resignation in order to contest South Shropshire | 
| Brecon | 6 February 1854 [16 1] | Charles Rodney Morgan |  | Conservative | John Lloyd Vaughan Watkins |  | Whig | Death | 
| East Gloucestershire | 9 January 1854 [16 1] | Marquess of Worcester |  | Conservative | Sir Michael Hicks Beach |  | Conservative | Succession to a peerage | 
| Clonmel | 21 December 1853 [16 1] | Cecil Lawless |  | Independent Irish | John O'Connell |  | Whig | Death | 
| South Warwickshire | 3 December 1853 [16 1] | Lord Brooke |  | Whig | Evelyn Shirley |  | Whig | Succession to a peerage | 
| Salisbury | 15 November 1853 | Charles Baring Wall |  | Whig | Edward Pery Buckley |  | Whig | Death | 
| Lisburn | 14 October 1853 [16 1] | Roger Johnson Smyth |  | Peelite | Jonathan Joseph Richardson |  | Whig | Death | 
| Dungarvan | 26 August 1853 | John Francis Maguire |  | Independent Irish | John Francis Maguire |  | Independent Irish | Seeks re-election upon becoming Mayor of Cork | 
| Clitheroe | 23 August 1853 | John Thomas Walshman Aspinall |  | Conservative | Le Gendre Starkie |  | Whig | Void By-Election | 
| Stamford | 22 August 1853 [16 1] | John Charles Herries |  | Conservative | Lord Robert Cecil |  | Conservative | Resignation | 
| Cork City | 20 August 1853 | Francis Murphy |  | Whig | Francis Beamish |  | Whig | Resignation (Commissioner for the Relief of Insolvent Debtors in England) | 
| South Staffordshire | 15 August 1853 [16 1] | George Anson |  | Whig | Edward Littleton |  | Whig | Resignation | 
| North Derbyshire | 22 July 1853 | William Evans |  | Whig | William Pole Thornhill |  | Ind. Whig [4]  [5] | Resignation | 
| West Cornwall | 18 July 1853 [16 1] | Edward Wynne-Pendarves |  | Whig | Michael Williams |  | Whig | Death | 
| Liverpool | 9 July 1853 | Charles Turner |  | Conservative | Thomas Horsfall |  | Conservative | Void election | 
| William Forbes Mackenzie |  | Conservative | Henry Liddell |  | Conservative | Void election | 
| Sligo Borough | 8 July 1853 | Charles Towneley |  | Independent Irish | John Sadleir |  | Whig | Void election | 
| Tralee | 4 July 1853 | Maurice O'Connell |  | Whig | Daniel O'Connell Jnr |  | Whig | Death | 
| Clare | 4 July 1853 | John Forster FitzGerald |  | Whig | John Forster FitzGerald |  | Whig | Void election | 
| Cornelius O'Brien |  | Independent Irish | Cornelius O'Brien |  | Independent Irish | Void election | 
| Stroud | 28 June 1853 [16 1] | Lord Moreton |  | Whig | Edward Horsman |  | Whig | Succession to a peerage | 
| Peterborough | 25 June 1853 | George Hammond Whalley |  | Whig | George Hammond Whalley |  | Whig | Void By-Election | 
| George Hammond Whalley |  | Whig | Thomson Hankey |  | Whig | By-election result reversed on petition | 
| Edinburghshire | 25 June 1853 [16 1] | John Hope |  | Conservative | Earl of Dalkeith |  | Conservative | Void election | 
| City Durham | 25 June 1853 | Lord Adolphus Vane |  | Conservative | John Mowbray |  | Conservative | Void By-Election | 
| Chatham | 23 June 1853 | John Mark Frederick Smith |  | Conservative | Leicester Viney Vernon |  | Conservative | Void election | 
| Harwich | 21 June 1853 | George Sandford |  | Conservative | John Bagshaw |  | Whig | Void election | 
| Plymouth | 2 June 1853 | Charles John Mare |  | Conservative | Roundell Palmer |  | Conservative | Void election | 
| Clitheroe | 28 May 1853 | Mathew Wilson |  | Whig | John Thomas Walshman Aspinall |  | Conservative | Void election | 
| Rye | 23 May 1853 | William Alexander Mackinnon (younger) |  | Whig | William Alexander Mackinnon (elder) |  | Whig | Void election | 
| Maidstone | 16 May 1853 | George Dodd |  | Conservative | William Lee |  | Whig | Void election | 
| Berwick-upon-Tweed | 14 May 1853 | John Stapleton |  | Whig | Dudley Marjoribanks |  | Whig | Void election | 
| Matthew Forster |  | Whig | John Forster |  | Whig | Void election | 
| Taunton | 4 May 1853 | Arthur Mills |  | Conservative | Sir John Ramsden |  | Whig | Void election | 
| County Carlow | 25 April 1853 [16 1] | Henry Bruen |  | Conservative | William McClintock-Bunbury |  | Conservative | Death | 
| Athlone | 23 April 1853 | William Keogh |  | Independent Irish | William Keogh |  | Whig | Solicitor-General for Ireland  [16 2] | 
| Huddersfield | 22 April 1853 | William Rookes Crompton Stansfield |  | Whig | Viscount Goderich |  | Whig | Void election | 
| Lancaster | 12 April 1853 | Robert Baynes Armstrong |  | Whig | Thomas Greene |  | Conservative | Void election | 
| Blackburn | 24 March 1853 | William Eccles |  | Whig | Montague Joseph Feilden |  | Whig | Void election | 
| Bridgnorth | 22 March 1853 [16 1] | Sir Robert Pigot |  | Conservative | John Pritchard |  | Conservative | Void election | 
| Frome | 7 March 1853 [16 1] | Robert Edward Boyle |  | Whig | Robert Edward Boyle |  | Whig | Void election | 
| West Worcestershire | 28 February 1853 [16 1] | Henry Lygon |  | Conservative | Viscount Elmley |  | Conservative | Succession to a peerage | 
| Forfarshire | 25 February 1853 [16 1] | Lauderdale Maule |  | Whig | Lauderdale Maule |  | Whig | Surveyor-General of the Ordnance  [16 2] | 
| Oxford University | 20 January 1853 | William Ewart Gladstone |  | Peelite | William Ewart Gladstone |  | Peelite | Chancellor of the Exchequer  [16 2] | 
| Carlow Borough | 20 January 1853 | John Sadleir |  | Independent Irish | John Alexander |  | Conservative | Junior Lord of the Treasury  [16 2] | 
| County Limerick | 12 January 1853 [16 1] | William Monsell |  | Whig | William Monsell |  | Whig | Clerk of the Ordnance  [16 2] | 
| Dumfriesshire | 12 January 1853 [16 1] | Viscount Drumlanrig |  | Peelite | Viscount Drumlanrig |  | Peelite | Comptroller of the Household  [16 2] | 
| South Wiltshire | 11 January 1853 [16 1] | Sidney Herbert |  | Peelite | Sidney Herbert |  | Peelite | Secretary at War  [16 2] | 
| Haddingtonshire | 11 January 1853 [16 1] | Lord Elcho |  | Peelite | Lord Elcho |  | Peelite | Junior Lord of the Treasury  [16 2] | 
| Cavan | 10 January 1853 [16 1] | Sir John Young |  | Peelite | Sir John Young |  | Peelite | Chief Secretary for Ireland  [16 2] | 
| Southampton | 7 January 1853 | Sir Alexander Cockburn |  | Whig | Sir Alexander Cockburn |  | Whig | Attorney General for England and Wales  [16 2] | 
| Aylesbury | 6 January 1853 [16 1] | Richard Bethell |  | Whig | Richard Bethell |  | Whig | Solicitor General for England and Wales  [16 2] | 
| Lichfield | 5 January 1853 [16 1] | Lord Alfred Paget |  | Whig | Lord Alfred Paget |  | Whig | Chief Equerry and Clerk Marshal  [16 2] | 
| Halifax | 5 January 1853 | Charles Wood |  | Whig | Charles Wood |  | Whig | President of the Board of Control  [16 2] | 
| Wolverhampton | 4 January 1853 [16 1] | Charles Pelham Villiers |  | Whig | Charles Pelham Villiers |  | Whig | Judge Advocate General  [16 2] | 
| Oxford | 4 January 1853 [16 1] | William Wood |  | Whig | Edward Cardwell |  | Peelite | Resignation (Vice Chancellor of the High Court) | 
| Marlborough | 4 January 1853 [16 1] | Lord Ernest Bruce |  | Peelite | Lord Ernest Bruce |  | Peelite | Vice-Chamberlain of the Household  [16 2] | 
| Leith Burghs | 4 January 1853 [16 1] | James Moncreiff |  | Whig | James Moncreiff |  | Whig | Lord Advocate  [16 2] | 
| Gloucester | 4 January 1853 | Maurice Berkeley |  | Whig | Maurice Berkeley |  | Whig | Second Sea Lord  [16 2] | 
| Brighton | 4 January 1853 [16 1] | Lord Alfred Hervey |  | Peelite | Lord Alfred Hervey |  | Peelite | Junior Lord of the Treasury  [16 2] | 
| Tiverton | 3 January 1853 [16 1] | The Viscount Palmerston |  | Whig | The Viscount Palmerston |  | Whig | Home Secretary  [16 2] | 
| Carlisle | 3 January 1853 [16 1] | Matthew Talbot Baines |  | Whig | Matthew Talbot Baines |  | Whig | President of the Poor Law Board  [16 2] | 
| City of London | 3 January 1853 [16 1] | Lord John Russell |  | Whig | Lord John Russell |  | Whig | Foreign Secretary  [16 2] | 
| Scarborough | 1 January 1853 [16 1] | Earl of Mulgrave |  | Whig | Earl of Mulgrave |  | Whig | Treasurer of the Household  [16 2] | 
| Nottingham | 1 January 1853 [16 1] | Edward Strutt |  | Whig | Edward Strutt |  | Whig | Chancellor of the Duchy of Lancaster  [16 2] | 
| Morpeth | 1 January 1853 [16 1] | Edward Granville George Howard |  | Whig | Sir George Grey |  | Whig | Resignation | 
| Hertford | 1 January 1853 [16 1] | William Cowper |  | Whig | William Cowper |  | Whig | Civil Lord of the Admiralty  [16 2] | 
| Carlisle | 1 January 1853 [16 1] | Sir James Graham |  | Peelite | Sir James Graham |  | Peelite | First Lord of the Admiralty  [16 2] | 
| Southwark | 1 January 1853 [16 1] | Sir William Molesworth |  | Radical | Sir William Molesworth |  | Radical | First Commissioner of Works  [16 2] | 
| Merthyr Tydfil | 14 December 1852 [16 1] | John Josiah Guest |  | Whig | Henry Bruce |  | Whig | Death | 
| Lisburn | 11 December 1852 | James Emerson Tennent |  | Conservative | Roger Johnson Smyth |  | Peelite | Resignation | 
| Peterborough | 6 December 1852 | Richard Watson |  | Whig | George Hammond Whalley |  | Whig | Death | 
| Bury St Edmunds | 4 December 1852 | John Stuart |  | Conservative | James Henry Porteous Oakes |  | Conservative | Resignation (Vice Chancellor) | 
| Oldham | 3 December 1852 | John Duncuft |  | Conservative | William Johnson Fox |  | Whig | Death | 
| City Durham | 3 December 1852 | Thomas Colpitts Granger |  | Whig | Lord Adolphus Vane |  | Conservative | Death | 
| Abingdon | 3 December 1852 | James Caulfeild |  | Whig | Lord Norreys |  | Whig | Death | 
|  | 
| By-election | Date | Former incumbent | Party | Winner | Party | Cause | 
|---|
| Huntingdonshire | 11 June 1852 [15 1] | George Thornhill |  | Conservative | Viscount Mandeville |  | Conservative | Death | 
| Sandwich | 28 May 1852 | Charles William Grenfell |  | Whig | Lord Charles Clinton |  | Conservative | Resignation in order to contest Windsor | 
| Windsor | 22 May 1852 | George Alexander Reid |  | Conservative | Charles William Grenfell |  | Whig | Death | 
| Perth | 15 May 1852 | Fox Maule |  | Whig | Arthur Kinnaird |  | Whig | Succession to a peerage | 
| Carmarthenshire | 13 May 1852 [15 1] | George Rice-Trevor |  | Conservative | David Jones |  | Conservative | Succession to a peerage | 
| Harwich | 8 May 1852 [15 1] | Fitzroy Kelly |  | Conservative | Isaac Butt |  | Conservative | Resignation in order to contest East Suffolk | 
| East Suffolk | 1 May 1852 [15 1] | The Lord Rendlesham |  | Conservative | Fitzroy Kelly |  | Conservative | Death | 
| Worcester | 28 April 1852 [15 1] | Francis Rufford |  | Conservative | William Laslett |  | Whig | Resignation | 
| Tavistock | 28 April 1852 | John Salusbury-Trelawny |  | Whig | Samuel Carter |  | Whig | Seeks re-election due to opposition from local party members | 
| Harwich | 10 April 1852 [15 1] | Robert Wigram Crawford |  | Whig | Fitzroy Kelly |  | Conservative | Void By-election | 
| Monmouth Boroughs | 3 April 1852 | Reginald James Blewitt |  | Whig | Crawshay Bailey |  | Conservative | Resignation | 
| Dungannon | 24 March 1852 [15 1] | William Stuart Knox |  | Conservative | William Stuart Knox |  | Conservative | Parliamentary Groom in Waiting  [15 2] | 
| South Shropshire | 23 March 1852 [15 1] | Viscount Newport |  | Conservative | Viscount Newport |  | Conservative | Vice-Chamberlain of the Household  [15 2] | 
| County Cork | 22 March 1852 | Maurice Power |  | Irish Repeal | Vincent Scully |  | Irish Repeal | Resignation (Governor of St. Lucia) | 
| Coleraine | 22 March 1852 [15 1]  [15 3] | John Boyd |  | Conservative | Lord Naas |  | Conservative | Resignation to provide a seat for Lord Naas | 
| East Retford | 19 March 1852 [15 1] | The Viscount Galway |  | Conservative | The Viscount Galway |  | Conservative | Lord-in-waiting  [15 2] | 
| County Londonderry | 13 March 1852 [15 1] | Thomas Bateson |  | Conservative | Thomas Bateson |  | Conservative | Junior Lord of the Treasury  [15 2] | 
| North Lincolnshire | 13 March 1852 [15 1] | Robert Adam Christopher |  | Conservative | Robert Adam Christopher |  | Conservative | Resignation pending appointment as Chancellor of the Duchy of Lancaster | 
| Kildare | 13 March 1852 [15 1]  [15 3] | Lord Naas |  | Conservative | William Henry Ford Cogan |  | Whig | Chief Secretary for Ireland  [15 2] | 
| Tyrone | 12 March 1852 [15 1] | Lord Claud Hamilton |  | Conservative | Lord Claud Hamilton |  | Conservative | Treasurer of the Household  [15 2] | 
| South Lincolnshire | 12 March 1852 [15 1] | Sir John Trollope |  | Conservative | Sir John Trollope |  | Conservative | President of the Poor Law Board  [15 2] | 
| Buckinghamshire | 12 March 1852 [15 1] | Benjamin Disraeli |  | Conservative | Benjamin Disraeli |  | Conservative | Chancellor of the Exchequer  [15 2] | 
| Oxfordshire | 10 March 1852 [15 1] | Joseph Warner Henley |  | Conservative | Joseph Warner Henley |  | Conservative | President of the Board of Trade  [15 2] | 
| East Riding of Yorkshire | 9 March 1852 [15 1] | Arthur Duncombe |  | Conservative | Arthur Duncombe |  | Conservative | Fourth Naval Lord  [15 2] | 
| North Essex | 9 March 1852 [15 1] | William Beresford |  | Conservative | William Beresford |  | Conservative | Secretary at War  [15 2] | 
| Enniskillen | 9 March 1852 | James Whiteside |  | Conservative | James Whiteside |  | Conservative | Solicitor-General for Ireland  [15 2] | 
| Dublin University | 9 March 1852 [15 1] | Joseph Napier |  | Conservative | Joseph Napier |  | Conservative | Attorney-General for Ireland  [15 2] | 
| Dorset | 9 March 1852 [15 1] | George Bankes |  | Conservative | George Bankes |  | Conservative | Judge Advocate General  [15 2] | 
| Portarlington | 8 March 1852 [15 1] | Francis Plunkett Dunne |  | Conservative | Francis Plunkett Dunne |  | Conservative | Clerk of the Ordnance  [15 2] | 
| Stamford | 6 March 1852 [15 1] | John Charles Herries |  | Conservative | John Charles Herries |  | Conservative | President of the Board of Control  [15 2] | 
| Midhurst | 5 March 1852 [15 1] | Spencer Horatio Walpole |  | Conservative | Spencer Horatio Walpole |  | Conservative | Home Secretary  [15 2] | 
| Buckingham | 5 March 1852 [15 1] | Marquess of Chandos |  | Conservative | Marquess of Chandos |  | Conservative | Junior Lord of the Treasury  [15 2] | 
| Abingdon | 5 March 1852 [15 1] | Sir Frederic Thesiger |  | Conservative | Sir Frederic Thesiger |  | Conservative | Attorney General for England and Wales  [15 2] | 
| Droitwich | 4 March 1852 [15 1] | Sir John Pakington |  | Conservative | Sir John Pakington |  | Conservative | Secretary of State for War and the Colonies  [15 2] | 
| Colchester | 4 March 1852 [15 1] | Lord John Manners |  | Conservative | Lord John Manners |  | Conservative | First Commissioner of Works  [15 2] | 
| Chichester | 4 March 1852 [15 1] | Lord Henry Lennox |  | Conservative | Lord Henry Lennox |  | Conservative | Junior Lord of the Treasury  [15 2] | 
| Wenlock | 3 March 1852 [15 1] | George Weld-Forester |  | Conservative | George Weld-Forester |  | Conservative | Comptroller of the Household  [15 2] | 
| East Kent | 16 February 1852 | John Pemberton Plumptre |  | Conservative | Sir Brook Bridges |  | Conservative | Resignation | 
| Kinsale | 12 February 1852 [15 1] | Benjamin Hawes |  | Whig | John Isaac Heard |  | Whig | Resignation | 
| Northampton | 11 February 1852 | Robert Vernon Smith |  | Whig | Robert Vernon Smith |  | Whig | Secretary at War  [15 2] | 
| Greenwich | 11 February 1852 | James Whitley Deans Dundas |  | Whig | Houston Stewart |  | Whig | Resignation | 
| East Retford | 11 February 1852 [15 1] | Arthur Duncombe |  | Conservative | William Ernest Duncombe |  | Conservative | Resignation in order to contest East Riding of Yorkshire | 
| Perth | 9 February 1852 [15 1] | Fox Maule |  | Whig | Fox Maule |  | Whig | President of the Board of Control  [15 2] | 
| Lisburn | 5 January 1852 [15 1] | Horace Beauchamp Seymour |  | Peelite | James Emerson Tennent |  | Conservative | Death | 
| Bradford | 21 October 1851 [15 1] | Robert Milligan |  | Whig | William Busfeild |  | Whig | Death | 
| East Riding of Yorkshire | 7 October 1851 [15 1] | Henry Broadley |  | Conservative | Arthur Duncombe |  | Conservative | Death | 
| Downpatrick | 8 August 1851 [15 1] | Richard Ker |  | Peelite | Charles Hardinge |  | Conservative | Resignation | 
| Limerick City | 1 August 1851 [15 1] | John O'Connell |  | Irish Repeal | Earl of Arundel |  | Ind. Whig [6] | Resignation | 
| Scarborough | 19 July 1851 | Earl of Mulgrave |  | Whig | George Frederick Young |  | Conservative | Comptroller of the Household  [15 2] | 
| Arundel | 16 July 1851 [15 1] | Earl of Arundel |  | Whig | Edward Strutt |  | Whig | Resignation in order to contest Limerick City | 
| Knaresborough | 12 July 1851 | William Lascelles |  | Whig | Thomas Collins |  | Conservative | Death | 
| Greenwich | 28 June 1851 | Edward George Barnard |  | Whig | David Salomons |  | Whig | Death | 
| Bath | 25 June 1851 | Lord Ashley |  | Conservative | George Treweeke Scobell |  | Whig | Succession to a peerage | 
| Clackmannanshire and Kinross-shire | 9 June 1851 | Sir William Morison |  | Whig | James Johnstone |  | Whig | Death | 
| Argyllshire | 6 June 1851 [15 1] | Duncan McNeill |  | Conservative | Sir Archibald Islay Campbell |  | Conservative | Resignation (Senator of the College of Justice) | 
| Newry | 30 May 1851 [15 1] | Viscount Newry |  | Peelite | Edmund Gilling Hallewell |  | Conservative | Death | 
| Isle of Wight | 29 May 1851 | John Simeon |  | Whig | Edward Dawes |  | Whig | Resignation | 
| Harwich | 28 May 1851 | Henry Thoby Prinsep |  | Conservative | Robert Wigram Crawford |  | Whig | Void By-Election | 
| Cork City | 23 April 1851 [15 1] | William Trant Fagan |  | Irish Repeal | Francis Murphy |  | Whig | Resignation | 
| Boston | 22 April 1851 | Dudley Pelham |  | Whig | James William Freshfield |  | Conservative | Death | 
| Longford | 21 April 1851 | Samuel Wensley Blackall |  | Irish Repeal | Richard More O'Ferrall |  | Whig | Resignation (Governor of Dominica) | 
| Leith Burghs | 14 April 1851 [15 1] | Andrew Rutherfurd |  | Whig | James Moncreiff |  | Whig | Resignation (Judge of the Court of Session) | 
| Enniskillen | 12 April 1851 | Henry Arthur Cole |  | Conservative | James Whiteside |  | Conservative | Resignation | 
| Aylesbury | 11 April 1851 | Frederick Calvert |  | Whig | Richard Bethell |  | Whig | Void By-Election | 
| West Somerset | 10 April 1851 [15 1] | Sir Alexander Hood |  | Conservative | William Gore-Langton |  | Conservative | Death | 
| Coventry | 8 April 1851 | George James Turner |  | Conservative | Charles Ponsonby |  | Whig | Resignation (Vice Chancellor) | 
| Oxford | 3 April 1851 [15 1] | William Page Wood |  | Whig | William Page Wood |  | Whig | Solicitor General for England and Wales  [15 2] | 
| Southampton | 2 April 1851 [15 1] | Alexander Cockburn |  | Whig | Alexander Cockburn |  | Whig | Attorney General for England and Wales  [15 2] | 
| Devonport | 2 April 1851 [15 1] | John Romilly |  | Whig | John Romilly |  | Whig | Master of the Rolls  [15 2] | 
| Dungarvan | 22 March 1851 | Richard Lalor Sheil |  | Whig | Charles Ponsonby |  | Whig | Resignation (Minister to Tuscany) | 
| Thirsk | 21 March 1851 [15 1] | John Bell |  | Conservative | Sir William Payne-Gallwey |  | Conservative | Death | 
| Harwich | 5 March 1851 | Sir John Hobhouse |  | Whig | Henry Thoby Prinsep |  | Conservative | Resignation and elevation to the peerage | 
| Glamorganshire | 25 February 1851 [15 1] | The Earl of Dunraven |  | Conservative | Sir George Tyler |  | Conservative | Resignation | 
| Bedfordshire | 24 February 1851 | Viscount Alford |  | Conservative | Richard Gilpin |  | Conservative | Death | 
| North Staffordshire | 22 February 1851 [15 1] | Viscount Brackley |  | Conservative | Sir Smith Child |  | Conservative | Resignation | 
| South Nottinghamshire | 17 February 1851 | Robert Bromley |  | Conservative | William Hodgson Barrow |  | Conservative | Death | 
| Falkirk Burghs | 14 February 1851 | Earl of Lincoln |  | Conservative | James Baird |  | Conservative | Succession to a peerage | 
| Dungannon | 14 February 1851 [15 1] | Viscount Northland |  | Conservative | William Stuart Knox |  | Conservative | Resignation | 
| Pontefract | 13 February 1851 | Samuel Martin |  | Whig | Beilby Lawley |  | Whig | Resignation (Baron of the Exchequer) | 
| Windsor | 10 February 1851 [15 1] | John Hatchell |  | Whig | John Hatchell |  | Whig | Attorney-General for Ireland  [15 2] | 
| Aylesbury | 27 December 1850 | The Lord Nugent |  | Whig | Frederick Calvert |  | Whig | Death | 
| St Albans | 24 December 1850 [15 4] | Alexander Raphael |  | Whig | Jacob Bell |  | Whig | Death | 
| County Limerick | 14 December 1850 | Samuel Dickson |  | Whig | Wyndham Goold |  | Whig | Death | 
| Herefordshire | 18 October 1850 [15 1] | Joseph Bailey |  | Conservative | Thomas William Booker-Blakemore |  | Conservative | Death | 
| Montgomeryshire | 11 October 1850 [15 1] | Charles Williams-Wynn |  | Conservative | Herbert Williams-Wynn |  | Conservative | Death | 
| Cambridge University | 4 October 1850 [15 1] | Charles Law |  | Conservative | Loftus Wigram |  | Conservative | Death | 
| Poole | 24 September 1850 | George Richard Robinson |  | Conservative | Henry Danby Seymour |  | Whig | Death | 
| Lambeth | 7 August 1850 | Charles Pearson |  | Whig | William Williams |  | Whig | Resignation | 
| Dungannon | 3 August 1850 [15 1] | Viscount Northland |  | Conservative | Viscount Northland |  | Conservative | Resigned seat and was re-elected without his knowledge or consent | 
| Mayo | 29 July 1850 [15 1] | Robert Dillon Browne |  | Irish Repeal | George Gore Ousley Higgins |  | Whig | Death | 
| Chester | 22 July 1850 [15 1] | John Jervis |  | Whig | William Owen Stanley |  | Whig | Resignation | 
| Tamworth | 19 July 1850 [15 1] | Sir Robert Peel |  | Peelite | Sir Robert Peel |  | Peelite | Death | 
| Southampton | 17 July 1850 [15 1] | Alexander Cockburn |  | Whig | Alexander Cockburn |  | Whig | Solicitor General for England and Wales  [15 2] | 
| Devonport | 17 July 1850 [15 1] | Sir John Romilly |  | Whig | Sir John Romilly |  | Whig | Attorney General for England and Wales  [15 2] | 
| Lymington | 30 April 1850 | George Keppel |  | Whig | Edward John Hutchins |  | Whig | Resignation | 
| Totnes | 30 March 1850 [15 1] | Lord Seymour |  | Whig | Lord Seymour |  | Whig | First Commissioner of Woods and Forests  [15 2] | 
| County Sligo | 12 March 1850 [15 1] | John Ffolliott |  | Conservative | Sir Robert Gore-Booth |  | Conservative | Resignation | 
| Canterbury | 4 March 1850 [15 1] | Albert Denison |  | Whig | Frederick Romilly |  | Whig | Resignation and elevation to the peerage | 
| Kirkcudbrightshire | 20 February 1850 [15 1] | Thomas Maitland |  | Whig | John Mackie |  | Whig | Resignation (Judge of the Court of Session) | 
| Colchester | 9 February 1850 [15 1] | George Henry Smyth |  | Conservative | Lord John Manners |  | Conservative | Resignation | 
| Windsor | 6 February 1850 [15 1] | Lord John Hay |  | Whig | John Hatchell |  | Whig | Resignation | 
| New Shoreham | 28 December 1849 [15 1] | Charles Goring |  | Conservative | Lord Alexander Gordon-Lennox |  | Conservative | Death | 
| Cork City | 14 November 1849 | Daniel Callaghan |  | Irish Repeal | James Charles Chatterton |  | Conservative | Death | 
| West Surrey | 27 September 1849 | William Denison |  | Whig | William John Evelyn |  | Conservative | Death | 
| Kidderminster | 5 September 1849 | Richard Godson |  | Peelite | John Best |  | Peelite | Death | 
| Reading | 8 August 1849 | Thomas Noon Talfourd |  | Whig | Viscount Chelsea |  | Conservative | Resignation (Puisne Judge of the Court of Common Pleas) | 
| Boston | 2 August 1849 | Sir James Duke |  | Whig | Dudley Pelham |  | Whig | Resignation in order to contest City of London | 
| City of London | 27 July 1849 [15 1] | James Pattison |  | Whig | Sir James Duke |  | Whig | Death | 
| City of London | 4 July 1849 | Lionel de Rothschild |  | Whig | Lionel de Rothschild |  | Whig | Seeks re-election following the rejection of the Jewish Disabilities Bill | 
| South Warwickshire | 7 June 1849 [15 1] | Evelyn Shirley |  | Conservative | Lord Guernsey |  | Conservative | Resignation | 
| Sutherland | 5 June 1849 [15 1] | Sir David Dundas |  | Whig | Sir David Dundas |  | Whig | Judge Advocate General  [15 2] | 
| County Limerick | 1 June 1849 [15 1] | William Smith O'Brien |  | Irish Confederate | Samuel Dickson |  | Whig | Disqualification (conviction for high treason) | 
| Sheffield | 3 May 1849 [15 1] | Henry George Ward |  | Whig | John Arthur Roebuck |  | Ind. Whig [7]  [8] | Resignation | 
| South Nottinghamshire | 17 April 1849 [15 1] | Lancelot Rolleston |  | Conservative | Robert Bromley |  | Conservative | Resignation | 
| North Hampshire | 6 April 1849 | Sir William Heathcote |  | Conservative | Melville Portal |  | Conservative | Resignation | 
| South Derbyshire | 23 March 1849 [15 1] | Edward Miller Mundy |  | Conservative | William Mundy |  | Conservative | Death | 
| Donegal | 20 February 1849 [15 1] | Edward Michael Conolly |  | Conservative | Thomas Conolly |  | Conservative | Death | 
| South Staffordshire | 19 February 1849 [15 1] | Viscount Ingestre |  | Conservative | Viscount Lewisham |  | Conservative | Succession to a peerage | 
| South Devon | 13 February 1849 [15 1] | Lord Courtenay |  | Conservative | Sir Ralph Lopes |  | Conservative | Resignation | 
| Cardigan Boroughs | 12 February 1849 | Pryse Pryse |  | Whig | Pryse Loveden |  | Whig | Death | 
| Bolton | 9 February 1849 | John Bowring |  | Whig | Joshua Walmsley |  | Whig | Resignation | 
| Kingston upon Hull | 7 February 1849 [15 1] | Matthew Talbot Baines |  | Whig | Matthew Talbot Baines |  | Whig | President of the Poor Law Board  [15 2] | 
| Portsmouth | 6 February 1849 [15 1] | Francis Baring |  | Whig | Francis Baring |  | Whig | First Lord of the Admiralty  [15 2] | 
| Leominster | 6 February 1849 [15 1] | Henry Barkly |  | Conservative | Frederick Peel |  | Conservative | Resignation (Governor of British Guiana) | 
| Truro | 11 January 1849 | Edmund Turner |  | Whig | Humphrey Willyams |  | Whig | Death | 
| Liskeard | 3 January 1849 [15 1] | Charles Buller |  | Whig | Richard Budden Crowder |  | Whig | Death | 
| King's Lynn | 22 December 1848 [15 1] | Lord George Bentinck |  | Conservative | Edward Stanley |  | Conservative | Death | 
| West Riding of Yorkshire | 11 December 1848 | Viscount Morpeth |  | Whig | Edmund Beckett |  | Conservative | Succession to a peerage | 
| Bolton | 12 September 1848 [15 1] | William Bolling |  | Conservative | Stephen Blair |  | Conservative | Death | 
| Cheltenham | 4 September 1848 | Craven Berkeley |  | Whig | Grenville Berkeley |  | Whig | Void election | 
| Leicester | 2 September 1848 [15 1] | Joshua Walmsley |  | Whig | John Ellis |  | Whig | Void election | 
| Richard Gardner |  | Whig | Richard Harris |  | Whig | Void election | 
| Derby | 2 September 1848 | Frederick Leveson-Gower |  | Whig | Michael Thomas Bass |  | Whig | Void election | 
| Edward Strutt |  | Whig | Lawrence Heyworth |  | Whig | Void election | 
| Thetford | 8 August 1848 [15 1] | Bingham Baring |  | Conservative | Francis Baring |  | Conservative | Succession to a peerage | 
| Sligo Borough | 15 July 1848 | Charles Towneley |  | Whig | John Patrick Somers |  | Irish Repeal | Void By-Election | 
| Great Yarmouth | 8 July 1848 | Lord Arthur Lennox |  | Conservative | Joseph Sandars |  | Conservative | Void election | 
| Octavius Coope |  | Conservative | Charles Rumbold |  | Whig | Void election | 
| Cheltenham | 29 June 1848 | Willoughby Jones |  | Conservative | Craven Berkeley |  | Whig | Void election | 
| Horsham | 28 June 1848 | John Jervis |  | Whig | William Vesey-FitzGerald |  | Conservative | Void election | 
| William Vesey-FitzGerald |  | Conservative | Lord Edward Howard |  | Whig | By-election result reversed on petition | 
| North Cheshire | 8 June 1848 | Edward Stanley |  | Whig | George Legh |  | Conservative | Elevation to the peerage | 
| York | 24 May 1848 | Henry Galgacus Redhead Yorke |  | Whig | William Milner |  | Whig | Death | 
| Cirencester | 24 May 1848 | William Cripps |  | Conservative | Joseph Randolph Mullings |  | Conservative | Death | 
| Wicklow | 27 April 1848 | William Acton |  | Conservative | Ralph Howard |  | Whig | Resignation | 
| Bewdley | 18 April 1848 | Thomas James Ireland |  | Conservative | Viscount Mandeville |  | Conservative | Void election | 
| Sligo Borough | 11 April 1848 | John Patrick Somers |  | Irish Repeal | Charles Towneley |  | Whig | Void election | 
| Rye | 6 April 1848 [15 1] | Herbert Mascall Curteis |  | Whig | Herbert Mascall Curteis |  | Whig | Void By-Election | 
| Devonport | 3 April 1848 [15 1] | John Romilly |  | Whig | John Romilly |  | Whig | Solicitor General for England and Wales  [15 2] | 
| Harwich | 1 April 1848 | John Attwood |  | Conservative | Sir John Hobhouse |  | Whig | Void election | 
| Aylesbury | 29 March 1848 | John Peter Deering |  | Conservative | Quintin Dick |  | Conservative | Void election | 
| Monmouthshire | 24 March 1848 [15 1] | Lord Granville Somerset |  | Conservative | Edward Arthur Somerset |  | Conservative | Death | 
| Lincoln | 16 March 1848 | Charles Seely |  | Whig | Thomas Hobhouse |  | Whig | Void election | 
| Carlisle | 14 March 1848 | William Nicholson Hodgson |  | Conservative | William Nicholson Hodgson |  | Conservative | Void election | 
| John Dixon |  | Whig | Philip Howard |  | Whig | Void election | 
| Kinsale | 11 March 1848 | Richard Samuel Guinness |  | Conservative | Benjamin Hawes |  | Whig | Void election | 
| Lancaster | 9 March 1848 | Samuel Gregson |  | Whig | Robert Baynes Armstrong |  | Whig | Void election | 
| Waterford City | 1 March 1848 | Daniel O'Connell |  | Irish Repeal | Sir Henry Barron |  | Whig | Resignation | 
| Devizes | 25 February 1848 [15 1] | William Heald Ludlow Bruges |  | Conservative | James Bucknall Bucknall Estcourt |  | Conservative | Resignation | 
| Dublin University | 19 February 1848 [15 1] | Frederick Shaw |  | Conservative | Joseph Napier |  | Conservative | Resignation | 
| North Shropshire | 16 February 1848 [15 1] | Viscount Clive |  | Conservative | John Whitehall Dod |  | Conservative | Succession to a peerage | 
| Wells | 27 December 1847 [15 1] | William Goodenough Hayter |  | Whig | William Goodenough Hayter |  | Whig | Judge Advocate General  [15 2] | 
| Calne | 27 December 1847 [15 1] | Earl of Shelburne |  | Whig | Earl of Shelburne |  | Whig | Junior Lord of the Treasury  [15 2] | 
| Rye | 23 December 1847 [15 1] | Herbert Barrett Curteis |  | Whig | Herbert Mascall Curteis |  | Whig | Death | 
| Sunderland | 22 December 1847 | David Barclay |  | Whig | Sir Hedworth Williamson |  | Whig | Resignation | 
| South Lancashire | 20 December 1847 [15 1] | Charles Pelham Villiers |  | Whig | Alexander Henry |  | Whig | Double election, chose to sit for Wolverhampton | 
| Tamworth | 18 December 1847 [15 1] | William Yates Peel |  | Conservative | John Townshend |  | Whig | Resignation | 
| Kilkenny City | 18 December 1847 [15 1] | John O'Connell |  | Irish Repeal | Michael Sullivan |  | Irish Repeal | Double election, chose to sit for Limerick City | 
| Stockport | 16 December 1847 | Richard Cobden |  | Radical | James Kershaw |  | Whig | Double election, chose to sit for the West Riding of Yorkshire | 
| Weymouth and Melcombe Regis | 15 December 1847 [15 1] | William Dougal Christie |  | Whig | Frederick Child Villiers |  | Conservative | Resignation (to avoid election petition) | 
| Newcastle-under-Lyme | 15 December 1847 | Samuel Christy |  | Conservative | Samuel Christy |  | Conservative | Seeks re-election due to his firm holding a government contract | 
| Edinburgh | 15 December 1847 [15 1] | Charles Cowan |  | Whig | Charles Cowan |  | Whig | Disqualification (held government contract) | 
| Liskeard | 14 December 1847 [15 1] | Charles Buller |  | Whig | Charles Buller |  | Whig | President of the Poor Law Board  [15 2] | 
|  |