Mucin 6

MUC6
Identifiers
Aliases	MUC6 , MUC-6, mucin 6, oligomeric mucus/gel-forming
External IDs	OMIM: 158374 MGI: 2663233 HomoloGene: 18768 GeneCards: MUC6
Gene location (Human)
Chr.	Chromosome 11 (human)
End	1,036,718 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,655,319 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; duodenum; ; body of stomach; ; gallbladder; ; fundus; ; sural nerve; ; islet of Langerhans; ; right lobe of liver; ; right uterine tube; ; canal of the cervix;
	Top expressed in
	duodenum; ; stomach; ; cerebellum; ; skeletal muscle tissue; ; cerebellar cortex; ; kidney; ; bone marrow; ; colon; ; olfactory bulb; ; superior frontal gyrus;
	More reference expression data
	n/a
Gene ontology
Molecular function	extracellular matrix structural constituent ;
Cellular component	Golgi lumen ; extracellular region ; plasma membrane ;
Biological process	maintenance of gastrointestinal epithelium ; O-glycan processing ; stimulatory C-type lectin receptor signaling pathway ;
	Sources:Amigo / QuickGO
Orthologs
	4588
	353328
	ENSG00000283350 ; ENSG00000277281 ; ENSG00000184956 ; ENSG00000277518
	ENSMUSG00000048191
	Q6W4X9
	Q80T03 ; Q0VAV1
	NM_005961
	NM_181729 ; NM_001330001 ; NM_001368953
	NP_005952
	NP_859418.1 ; NP_001316930 ; NP_001355882
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

Mucin 6, oligomeric mucus/gel-forming, also known as MUC6, is a human gene encoding a protein of the same name.^[5] MUC6, along with MUC2, MUC5AC, and MUC5B, is located within the 11p15 chromosomal locus of chromosome 11. MUC6, along with MUC1, is expressed in normal pancreases.^[6]

Related Research Articles

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Mucin-5B(MUC-5B) is a protein that in humans is encoded by the MUC5B gene and by Muc5b gene in mouse. It is one of the five gel-forming mucins. MUC-5B can be found in whole saliva, normal lung mucus, and cervical mucus. In some diseases such as COPD, chronic rhinosinusitis (CRS), and H. pylori-associated gastric disease.

Polypeptide N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the GALNT1 gene.

Mucin 3A is a protein that in humans is encoded by the MUC3A gene.

IgGFc-binding protein is a protein that in humans is encoded by the FCGBP gene.

Mucin-20 is a protein that in humans is encoded by the MUC20 gene.

Mucin and cadherin-like protein is a protein that in humans is encoded by the MUPCDH gene.

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Homeobox C12 is a protein that in humans is encoded by the HOXC12 gene.

Aquaporin-6, (AQP-6) also known as kidney-specific aquaporin is a protein in humans that is encoded by the AQP6 gene.

Inositol monophosphatase 3 also known as inositol monophosphatase domain-containing protein 1 (IMPAD1) is an enzyme that in humans is encoded by the IMPAD1 gene.

PHD finger protein 2 is a protein that in humans is encoded by the PHF2 gene.

Von Willebrand factor A domain containing 5A is a protein that in humans is encoded by the VWA5A gene.

Chromosome 15 open reading frame 48 is a protein that in humans is encoded by the C15orf48 gene.

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References

1 2 3 ENSG00000277281, ENSG00000184956, ENSG00000277518 GRCh38: Ensembl release 89: ENSG00000283350, ENSG00000277281, ENSG00000184956, ENSG00000277518 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048191 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: MUC6 mucin 6, oligomeric mucus/gel-forming".
↑ Monges, Genevieve M.; Mathoulin-Portier, Marie-Pierre A. (2005). "Role of Mucins in Pancreatic Carcinoma". Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas. 3: 351–356. doi:10.1016/S1874-5784(05)80040-6 . Retrieved 12 February 2023.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000277281, ENSG00000184956, ENSG00000277518 GRCh38: Ensembl release 89: ENSG00000283350, ENSG00000277281, ENSG00000184956, ENSG00000277518 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048191 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: MUC6 mucin 6, oligomeric mucus/gel-forming".

[6] Monges, Genevieve M.; Mathoulin-Portier, Marie-Pierre A. (2005). "Role of Mucins in Pancreatic Carcinoma". Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas. 3: 351–356. doi:10.1016/S1874-5784(05)80040-6 . Retrieved 12 February 2023.

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