Osteoglycin

OGN
Identifiers
Aliases	OGN , OG, OIF, SLRR3A, osteoglycin
External IDs	OMIM: 602383; MGI: 109278; HomoloGene: 8542; GeneCards: OGN; OMA:OGN - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q22.31 Start 92,383,268 bp [1] End 92,404,696 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 A5 Start 49,761,522 bp [2] End 49,777,977 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery Descending thoracic aorta parietal pleura ascending aorta gallbladder decidua left coronary artery tendon of biceps brachii cartilage tissue vena cava Top expressed in tunica media of zone of aorta sciatic nerve calvaria epithelium of lens ciliary body cervix left lung carotid body efferent ductule external carotid artery More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding growth factor activity extracellular matrix structural constituent conferring compression resistance Cellular component extracellular vesicle extracellular matrix lysosomal lumen Golgi lumen extracellular exosome extracellular space extracellular region collagen-containing extracellular matrix Biological process negative regulation of smooth muscle cell proliferation axonogenesis keratan sulfate catabolic process keratan sulfate biosynthetic process regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4969 18295 Ensembl ENSG00000106809 ENSMUSG00000021390 UniProt P20774 Q62000 RefSeq (mRNA) NM_033014 NM_014057 NM_024416 NM_008760 RefSeq (protein) NP_054776 NP_077727 NP_148935 NP_054776.1 NP_148935.1 NP_032786 Location (UCSC) Chr 9: 92.38 – 92.4 Mb Chr 13: 49.76 – 49.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein. ^[5]

This gene encodes a protein which induces ectopic bone formation in conjunction with transforming growth factor beta. This protein is a small keratan sulfate proteoglycan ^[6] which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript variants. ^[5]

The level of expression of this gene has been correlated with enlarged hearts and more specifically left ventricular hypertrophy. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000106809 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000021390 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OGN osteoglycin".
6. Funderburgh JL, Corpuz LM, Roth MR, Funderburgh ML, Tasheva ES, Conrad GW (1997). "Mimecan, the 25-kDa corneal keratan sulfate proteoglycan, is a product of the gene producing osteoglycin". J Biol Chem. 272 (44): 28089–95. doi: 10.1074/jbc.272.44.28089 . PMID   9346963.
7. "Big hearts 'have genetic problem'". Health. BBC News. 2008-06-06. Retrieved 2008-06-07.
8. Petretto E, Sarwar R, Grieve I, Lu H, Kumaran MK, Muckett PJ, Mangion J, Schroen B, Benson M, Punjabi PP, Prasad SK, Pennell DJ, Kiesewetter C, Tasheva ES, Corpuz LM, Webb MD, Conrad GW, Kurtz TW, Kren V, Fischer J, Hubner N, Pinto YM, Pravenec M, Aitman TJ, Cook SA (May 2008). "Integrated genomic approaches implicate osteoglycin (Ogn) in the regulation of left ventricular mass". Nat. Genet. 40 (5): 546–52. doi:10.1038/ng.134. PMC   2742198 . PMID   18443592.

Further reading

• Kukita A, Bonewald L, Rosen D, et al. (1990). "Osteoinductive factor inhibits formation of human osteoclast-like cells". Proc. Natl. Acad. Sci. U.S.A. 87 (8): 3023–6. Bibcode:1990PNAS...87.3023K. doi: 10.1073/pnas.87.8.3023 . PMC   53826 . PMID   2326263.
• Madisen L, Neubauer M, Plowman G, et al. (1990). "Molecular cloning of a novel bone-forming compound: osteoinductive factor". DNA Cell Biol. 9 (5): 303–9. doi:10.1089/dna.1990.9.303. PMID   2372374.
• Tasheva ES, Funderburgh ML, McReynolds J, et al. (1999). "The bovine mimecan gene. Molecular cloning and characterization of two major RNA transcripts generated by alternative use of two splice acceptor sites in the third exon". J. Biol. Chem. 274 (26): 18693–701. doi: 10.1074/jbc.274.26.18693 . PMID   10373482.
• Matsushima N, Ohyanagi T, Tanaka T, Kretsinger RH (2000). "Super-motifs and evolution of tandem leucine-rich repeats within the small proteoglycans--biglycan, decorin, lumican, fibromodulin, PRELP, keratocan, osteoadherin, epiphycan, and osteoglycin". Proteins. 38 (2): 210–25. doi:10.1002/(SICI)1097-0134(20000201)38:2<210::AID-PROT9>3.0.CO;2-1. PMID   10656267. S2CID   39643243.
• Pellegata NS, Dieguez-Lucena JL, Joensuu T, et al. (2000). "Mutations in KERA, encoding keratocan, cause cornea plana". Nat. Genet. 25 (1): 91–5. doi:10.1038/75664. PMID   10802664. S2CID   8837115.
• Tasheva ES, Pettenati M, Von Kap-Her C, Conrad GW (2000). "Assignment of mimecan gene (OGN) to human chromosome band 9q22 by in situ hybridization". Cytogenet. Cell Genet. 88 (3–4): 326–7. doi:10.1159/000015521. PMID   10828622. S2CID   39568354.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi: 10.1073/pnas.160270997 . PMC   16901 . PMID   10931946.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC   1083732 . PMID   11256614.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tasheva ES, Conrad GW (2003). "The UV responsive elements in the human mimecan promoter: a functional characterization". Mol. Vis. 9: 1–9. PMID   12533723.
• Luijendijk MW, van de Pol TJ, van Duijnhoven G, et al. (2004). "Cloning, characterization, and mRNA expression analysis of novel human fetal cochlear cDNAs". Genomics. 82 (4): 480–90. doi:10.1016/S0888-7543(03)00150-2. PMID   13679028.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Hu SM, Li F, Yu HM, et al. (2006). "The mimecan gene expressed in human pituitary and regulated by pituitary transcription factor-1 as a marker for diagnosing pituitary tumors". J. Clin. Endocrinol. Metab. 90 (12): 6657–64. doi: 10.1210/jc.2005-0322 . PMID   16189248.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.